I would just like to add to this that there seems to be a general misconception (all around) that ibuprofen/NSAIDs in combination with opiates
are somehow safer to take more of than opiates that are formulated in combination with APAP
. While there is ever increasing awareness on the dangerous of too much APAP and its effects on the liver, double dosing NSAIDs too often can lead to much more serious gasto-intestinal problems, notably tears in the stomach lining and ulcers in various parts of the GI system. This won't happen with one double dose, but do it too much and you really put yourself at higher risk for a serious issue... especially if one takes other NSAIDs (with or without a narcotic) for other generalized pain. It does not sound like your friend consistently takes these doses, and Mindless is indeed correct that the adverse effects could have easily been caused by either of the two active ingredients. Caution must be used when taking extra doses of any medication that is a combination of a narcotic and either APAP (Tylenol, Paracetamol
) or an NSAID.