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I Say, Why not conduct structure-activity relationship studies on Euphoric Drugs to determine which drugs are the Most Euphoric & Pleasureable, with the Fewest side-effects?
This Re-search should be conducted with the same diligence we apply to searching for the best chemotherapy for cancer or any other disease.
Why shouldn't patients have access to the most euphoric and pleasureable drugs to alleviate their suffering and make therapy as pleasant as possible?
As William Blake Stated So Well...
" Some say that Happiness is not Good for Mortals, & they ought be answer'd that Sorrow is not fit for Immortals & is utterly useless to anyone!!!
Instead of pursuing the impossible goal of engineering the euphoria out of pain-killing drugs, we need to find the Ideal one!
Nobody disputes the widespread utility & need for opiates in many branches of medicine. Its High Time we abandoned any notion of the non-addicting narcotic, and instead concentrate on finding the drug which the patients like best!!!
I think it would be not in the least difficult to find Volunteers for this type investigation. Since there is a considerable body of empirical testing which has been conducted outside the laboratory among narcotics "habitues",
surveys can indicate promising candidates. Heroin has long been regarded to be a favorite drug of narcotics users, and would be a good place to start looking for the optimum narcotic.
the use of Brompton's Cocktail ( a mixture of heroin, cocaine and alcohol ) in British hospices for terminal patients is an example of comfort-oriented therapy which ought to be followed more often in the United States,
I think that if non-terminal patients suffer less and thus feel better their convalescence times will be reduced!
Gottfried Benn proposed just this sort of Re-search, which he aptly characterized as "provoked of life", commenting; "potent brains are not strengthened by milk but by alkaloids".
Perhaps anyone reading this would like to help start this search by stating in your opinion... what is the Most Euphoric Narcotic & why it works best for you!!!
Last edited by Doctor Who; 05-03-2012 at 18:18.
Psychoactives of all classes can help people in different circumstances in daily life. Opiates can help with moments of depression, emotional and physical pain - especially potent mu opioid agonists, particularily oxycodone, morphine. Heroin shouldn't be used unless in absolutely dire situations, like the acceptance of the transition towards near death when one is in a state of physical, incurable sickness.
Potent dopamine reuptake inhibitors like methylphenidate and cocaine can help with enhancing life through the euphoria they induce. To keep the side-effects to a minimum, it'd be preferable to stay away from dopamine releasers like methamphetamine and amphetamine due to their neurotoxicity. Cocaine wouldn't a wise choice either due to the addictive potentiality and cardiovascular toxicitiy. Comedowns could be minimized with proper nutrition and vitamin supplementation, a benzo or melatonin to help with sleep. The ROA should be oral or sublingual, as insufflation of methylphenidate or cocaine has negative effects on the nose - unless the methylphenidate is 100% pure.
Moderation is a key element here, to minimize tolerance build up and dependence. Only in situations where these drugs might be needed temporarily would they have maximum efficiency.
I've put in a little Re-search & came up with this...
Diacetyldihydromorphine ( also known as... Paralaudin, Dihydroheroin, or acetylmorphinol ) is a potent 0piate derivative developed in Germany in 1929 which is rarely used in some countries for the treatment of severe pain such as that caused by terminal cancer, as a more potent form of Heroin. Diacetyldihydromorphine is fast acting and longer lasting than Heroin, with a duration of action of around 5-7 hours. Side effects of diacetyldihydhydromorphine are similar to those of other semi-synthetic 0piates, and the most commonly reported side effects include euphoria, drowsiness, nausea, and constipation.
Now if only the FDA will start the re-search needed to approve it...
Last edited by Doctor Who; 06-03-2012 at 07:07.