shows little metabolic toxicity when taken without pyrolysis.
When smoked or even vaporized in a glass pipe - where the powder turns dark brown on melting - 5F-AKB48 is transformed into a variety of toxic chemicals.
Similar to a burning Teflon frying pan, 5F-AKB48's Fluorines can recombine with other atoms in a large variety of ways. One of the ways is Perfluorooctanoic Acid. Another one is HF - Hydrofluoric acid.
HF is a certainty with any pyrolized fluorinated molecule. HF is a strong mineral acid that is highly corrosive to tissue.
There's worse than HF. After a couple years of once-a-day, I notice these things.
One of those things is the foul smell produced after smoking. In the pipe and eventually on everything.
Another is that same or very similar smell on sweat for a day or more after.
A toxic odor so pervasive that it soaks my clothes and eventually even the washing machine reeks.
Another is the swollen feet gradually losing nerve sensation.
seems to inhibit Oxygen absorption / respiration.
Then there is the chronic lung infections and cough.
What is worst is that these toxic effects seem to be cumulative like nuclear radiation, or like Fluoroquinolone antibiotic exposure. A series of exposures can produce few or no symptoms but when the body's toxicity threshold
is surpassed the symptoms can suddenly and dramatically appear.
Just a single dose, or just a dozen once-each-day many months or even a year after quitting can bring back toxicity symptoms to nearly their maximum during a previous peak regime.
That is a sign that something or a lot of things that are not easily fixable get damaged a bit after each dose of 5F-AKB48. Then when those things reach a critical level of damage or functional loss, the cumulative symptoms start to show.
Here are some theories. Cannabinoids
lower mitochondrial energy conversion. Synthetic full agonists are stronger than natural partials. So they ought to lower it more.
What mangled molecules manage to get into the body and the brain when a halogenated drug is pyrolyzed?
Perhaps, twisted molecules that can never be broken from their ligand receptors. Covalent bonds.
Fluorine is this Universe's most electronegative element. It forms carbon bonds that are tighter than anything else. That's why Teflon is so useful. I know how useful Teflon is. I managed to inhale two or maybe three lungfuls of Teflon smoke thanks to a roommate's carelessness. He caused a Teflon fire and I had to deal with it. That fire filled the entire room with pure Teflon smoke - the pot
was empty. In ten minutes I had fume fever and since that day three years ago I have not been able to breath properly.
Life never succeeded in making much use of halogens bound organically inside molecules - Iodine excepted. Fluorine and Chlorine are just too strong. They tend to irreversibly bind things. They are too strongly electronegative. Same with heavy metals. Some rare exceptions are Cobalt(III), Chromium and Vanadium.
That's not to say that halogenated drugs
are evil. But mangling them, mutilating them before they get inside can turn into lots of problems.
There are safe 'wooden' cannabinoids - the CHMINACAs apart from FUB. They produce high CB2 activation and low CB1 activation; good for sleep and medical purposes. Even used once a day though, they don't produce the psychedelic
high CB1 activation. Of course they are not 'receptor-safe' as most potent drugs are not. But they won't damage other body systems due to pyrotox products.
It seems there has been a failure of chemistry to produce high-CB1 activators that lack the 'required' Fluoropentyl chain or paraFluorobenzene. Yet this fluorination is a cumulative, insidious sickening killer.
There is ADAMANTYL-THPINACA which is my hope and is predicted to produce decently high CB1 activation.
We are out of luck if 5F-AKB48's Adamantane group is implicated in any toxicity.
If pyrolysis or inherent metabolic toxicity can't be avoided, it seems the best option is to use hyperpotent Fluoronoids. 5F-AMB. Microdoses can be used to limit damage, or it can be used orally.
For long duration or sleep there are the CHMINACAs and a few other non-halogenated options.
If anyone can post a list of non-halogenated cannabinoids and their respective CB1 / CB2 dominance I would be very pleased. A safe list. Not safe for receptors of course, but the safety of everything else in a body from pyrolysis and metabolic toxicants.
That distinction - between 'toxicity' symptoms that are caused by receptor over- or under-activation - and that caused by disruption of all those other body systems by the drug, its metabolites, and any pyrolytic products consumed due to smoking/vaporizing. Even vaporizing. 5F-AKB48 reacts with itself and/or air at its evaporation temperature. It cannot be cleanly vaporized in air.
So I am also very interested to hear from others about these toxic symptoms - not the receptor effects. Some of the receptor effects are (agonist & withdrawal
): sweating, low appetite, vomiting, depression, low Testosterone, low energy, poor memory.
The other toxic effects are very distinct: the 'toxic feeling' body-wide isn't associated with CB receptors.
Neither is the poor Oxygen utilization, nor the swollen painful feet. I'm pretty sure not.
The lung toxicity has nothing to do with CB receptors and everything to do with Fluorine. Hydrofluoric acid and every Fluorinated organic/inorganic molecule a good chemist could imagine.