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  #1  
Old 16-12-2012, 05:07
Zaweht Zaweht is offline
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Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

Doing some cleaning came across an old scrip for promethazine-vc codeine syrup (phenergan vc with codeine). Apparently it contains phenylephrine hcl in addition to the codeine and promethazine. My question is, if I plan on drinking this bottle (3/4's) of it left will the phenylephrine hcl be dangerous at a recreational dose?

Zaweht added 8 Minutes and 57 Seconds later...

I've looked in other forums and online for more information. Didn't find a single thing about phenergan with codeine. Somebody on here must know something! Come on!

Zaweht added 0 Minutes and 18 Seconds later...

Wondering if I can do a CWE on a syrup?

Last edited by Zaweht; 16-12-2012 at 05:07. Reason: Automerged Doublepost
  #2  
Old 15-01-2013, 20:43
GeographyGeography GeographyGeography is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

Everywhere I look It says this preparation also contains phenylephrine, but it doesn't list this as an ingredient on my bottle it just says "PROMETHAZINE VC- CODEINE SYRUP common brands: Phergan VC with Codeine. Very confusing- I cant really even find good dosing info. It seems its 10mg codeine/6.25 promethazine per 5ml of liquid. But does it contain phenylephrine or not???? CWE wouldn't work on phenylephrine sadly

Last edited by GeographyGeography; 16-01-2013 at 21:36.
  #3  
Old 16-01-2013, 04:40
Zaweht Zaweht is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

Quote:
Originally Posted by GeographyGeography View Post
Everywhere I look It says this preparation also contains phenylephrine, but it doesn't list this as an ingredient on my bottle it just says "PROMETHAZINE VC- CODEINE SYRUP common brands: Phergan VC with Codeine. Very confusing- I cant really even find good dosing info. It seems its 10mg codeine/6.25 promethazine per 5ml of liquid. But does it contain phenylephrine or not????
That's exactly what confused me! Ugh. Maybe check the prescription number or find a pharmacist friend who can help you out
  #4  
Old 16-01-2013, 05:30
GeographyGeography GeographyGeography is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

The pharmacist said it indeed does contain phenylephrine. Looks like this one will be annoying to abuse. I can't even find solid data on what an overdosage of phenylephrine is. One site says 60mg/day is max, an older website says 80mg/day max. Also read an article about how they are trying to increase the pill-dosage from 10mg to 25mg. hypertensive crisis? Le sigh. Fucking qualitest.

This is all I could really find so far
"The threshold dosage of PE administered orally in man for any effects on the cardiovascular system is about 50 mg and at this dose PE causes a decline in heart rate and a slight increase in arterial blood pressure [14]."

Large excesses of phenylephrine are required to cause increases in blood pressure; up
to 120mg. 50mg of phenylephrine (5 tablets of the proposed product) as a single dose
has been documented as the minimum amount required to cause an increase in blood
pressure. 10mg phenylephrine was found not to affect blood pressure.

Also, promethazine VC with codeine contains phenylephrine HCL, of which 12.18mgs is equivalent to 10mgs free phenylephrine. So we can safely say that 60ml (2 oz) of the syrup would contain 120mgs codeine/ 78mgs promethazine/ 60mgs phenylephrine HCL [47mgs phenylephrine]

also found this petition to the FDA:

Chua and Benrimoj evaluated the literature on the effects
of non-prescription sympathomimetic agents on blood pressure.25 They found
that a dose of 120 mg of oral phenylephrine was required to increase blood
pressure in normotensive subjects, i.e., a dose that was at least 12 times the
current maximum FDA-approved dose. In contrast, pseudoephedrine produced
a significant increase in blood pressure at 120 mg, i.e., only twice the maximum
recommended dose. The likely explanation for the difference in therapeutic
margins between phenylephrine and pseudoephedrine is the high first pass
metabolism of oral phenylephrine.
Elis et all reported that 45 mg of phenylephrine given alone did not increase
blood pressure, but when taken with a monoamine oxidase inhibitor (MAOI)
produced an alarming increase in BP requiring reversal with phentolamine, an a blocker. They also noted that phenylephrine 10 mg alone did not produce any
effect on blood pressure, but when given concurrently with a MAOI, this dose
produced an increase in blood pressure. These data suggest that monoamine
oxidase plays an important role in the first-pass metabolism of phenylephrine and
blocking the inactivation of phenylephrine by monoamine oxidase allows greater
concentrations to reach al receptors.
Since an oral dose of 120 mg or higher of phenylephrine is required to increase
blood pressure in normotensive patients, we believe that increasing the labeled
dose to 25 mg should not increase the risk of systemic adverse effects. It would
be prudent, however, to conduct further safety assessment of the 25-mg dose.

Post Quality Evaluations:
good, relavent information

Last edited by GeographyGeography; 16-01-2013 at 08:18.
  #5  
Old 18-01-2013, 00:02
SmaLLtown SmaLLtown is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

It contains phenylephrine hydrochloride 5 mg per tsp (5mL), so 30mg per oz so to speak. I do believe I have chimed in many times previously about promethazine/codeine aka the no longer named brand phenergan with codeine (with and without vc) before on here.

Knowing that all drugs effect an individual differently, I will lend personal experience. Before qualitest, promethazine vc codeine syrup was made by Alpharma, Actavis, Barre, etc. It tasted really good therefore a lot was experimented with. I found no adverse side effects of the phenylephrine as opposed to promethazine/codeine syrup in moderate doses 4oz and below. I never sat down and really checked by BP though, but I didn't notice anything that set off any alarms. As with any drug though, use caution.

It was discontinued by Actavis, it is only produced by Qualitest at the current time.
Personal preference, but it tastes god awful compared to the original.

Post Quality Evaluations:
solid info

Last edited by SmaLLtown; 19-01-2013 at 09:04.
  #6  
Old 19-01-2013, 04:02
GeographyGeography GeographyGeography is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

Smalltown would you mind sharing your weight with us?
  #7  
Old 19-01-2013, 09:54
SmaLLtown SmaLLtown is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

Quote:
Originally Posted by GeographyGeography View Post
Smalltown would you mind sharing your weight with us?
It's more about tolerance than weight. I know people who are small with big tolerances. Anyway, with that being said.... I'm a big guy, picture nfl type build, 6'5 - 275lbs.
  #8  
Old 21-01-2013, 08:49
Zaweht Zaweht is offline
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Re: Promethazine-VC Codeine Syrup (Phenergan VC with Codeine)-Dangerous?

Quote:
Originally Posted by SmaLLtown View Post
It's more about tolerance than weight. I know people who are small with big tolerances. Anyway, with that being said.... I'm a big guy, picture nfl type build, 6'5 - 275lbs.
Yeah, I actually ended up trying the scrip out regardless and I didn't get any negative side effects. However, I am a big guy as well so that may be a significant factor. I didn't end up getting a true "codeine high" as my friends had described it to me previously. I think the promethazine was too sedating for me because I ended up just passing out. I had some crazy euphoria though.

I dosed slowly, about a quarter of the bottle evey 30-45 mins because I was sketched about the possibility of overdosing on phenylphenphrine (I can't really spell right now I'm too drunk lol) but I think me being overly cautious about the whole experience might have ruined the recreational value of the drug for me. But anyway I did end up having fun, but I didn't think it was anything special either.

I'd try it again though if the opportunity presents itself :P

Zaweht added 5 Minutes and 39 Seconds later...

Quote:
Originally Posted by GeographyGeography View Post
The pharmacist said it indeed does contain phenylephrine. Looks like this one will be annoying to abuse. I can't even find solid data on what an overdosage of phenylephrine is. One site says 60mg/day is max, an older website says 80mg/day max. Also read an article about how they are trying to increase the pill-dosage from 10mg to 25mg. hypertensive crisis? Le sigh. Fucking qualitest.

This is all I could really find so far
"The threshold dosage of PE administered orally in man for any effects on the cardiovascular system is about 50 mg and at this dose PE causes a decline in heart rate and a slight increase in arterial blood pressure [14]."

Large excesses of phenylephrine are required to cause increases in blood pressure; up
to 120mg. 50mg of phenylephrine (5 tablets of the proposed product) as a single dose
has been documented as the minimum amount required to cause an increase in blood
pressure. 10mg phenylephrine was found not to affect blood pressure.

Also, promethazine VC with codeine contains phenylephrine HCL, of which 12.18mgs is equivalent to 10mgs free phenylephrine. So we can safely say that 60ml (2 oz) of the syrup would contain 120mgs codeine/ 78mgs promethazine/ 60mgs phenylephrine HCL [47mgs phenylephrine]

also found this petition to the FDA:

Chua and Benrimoj evaluated the literature on the effects
of non-prescription sympathomimetic agents on blood pressure.25 They found
that a dose of 120 mg of oral phenylephrine was required to increase blood
pressure in normotensive subjects, i.e., a dose that was at least 12 times the
current maximum FDA-approved dose. In contrast, pseudoephedrine produced
a significant increase in blood pressure at 120 mg, i.e., only twice the maximum
recommended dose. The likely explanation for the difference in therapeutic
margins between phenylephrine and pseudoephedrine is the high first pass
metabolism of oral phenylephrine.
Elis et all reported that 45 mg of phenylephrine given alone did not increase
blood pressure, but when taken with a monoamine oxidase inhibitor (MAOI)
produced an alarming increase in BP requiring reversal with phentolamine, an a blocker. They also noted that phenylephrine 10 mg alone did not produce any
effect on blood pressure, but when given concurrently with a MAOI, this dose
produced an increase in blood pressure. These data suggest that monoamine
oxidase plays an important role in the first-pass metabolism of phenylephrine and
blocking the inactivation of phenylephrine by monoamine oxidase allows greater
concentrations to reach al receptors.
Since an oral dose of 120 mg or higher of phenylephrine is required to increase
blood pressure in normotensive patients, we believe that increasing the labeled
dose to 25 mg should not increase the risk of systemic adverse effects. It would
be prudent, however, to conduct further safety assessment of the 25-mg dose.

Great information. Thank you!

It seems that getting my hands on a legit codeine preparation is nearly impossible nowadays. *sigh*

Last edited by Zaweht; 21-01-2013 at 08:49. Reason: Automerged Doublepost

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