Originally Posted by AlteredEnthusiasm
BudBars I would like to see a source on that one. Oxycodone
differ by two hydrogen atoms and effect the same receptors in the same way just in different potencies. They also have the same active metabolites. I cannot see how APAP
would potentiate Hydro (via magical chemical reactions) but not Oxy.
I agree with you that there is not magical synergy between hydrocodone and APAP. However, hydrocodone and oxycodone do not have the same metabolites. Hydrocodone => hydromorphone
and oxycodone => oxymorphone
To the OP's question. They combine the two drugs
in hopes to improve analgesic response, which studies did show actually happens. Now they don't have any (at least easily available) formulations of hydrocodone without APAP, and keep it this way in order to deter abuse, but again this is only part of the reason. Initially it was to improve the drugs effective pain killing response (not the high).
Oxycodone was probably chosen to have formulations without APAP/ibuprofen as it has a better pain killer effect (i.e. greater analgesic response), as opposed to hydrocodone alone or mixed. Although this is just speculation, I am not sure if that's the exact reasoning or not. And, in the treatment of cancer pain, it was shown to have equal analgesia, but less side-effects when compared to morphine
. Not sure if they even bothered looking at hydrocodone for this, doubt it as oxy is stronger anyway.
Just FYI, a few pharmaceutical companies are in the process of developing a sustained release hydrocodone that will not contain APAP or ibuprofen.