Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News
Go Back   Drugs Forum > DRUG-FORUMS > Opiates & Opioids > Codeine
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 22-06-2013, 17:40
fleeman fleeman is offline
Newbie
 
Join Date: 08-06-2013
22 y/o Male from Canada
Posts: 7
fleeman is an unknown quantity at this point
Points: 39, Level: 1 Points: 39, Level: 1 Points: 39, Level: 1
Activity: 0.2% Activity: 0.2% Activity: 0.2%
How much Codeine metabolizes into Morpine?

Hey first post here.

I have looked up and down this forum for an answer but couldn't find anything.

A Buddy of mine was wondering how much codeine actually metabolizes into Morphine?

For example if he were to take 50mg of codeine, how much of that would metabolize into morphine?

thanks in advance for any replies!
  #2  
Old 22-06-2013, 18:18
Millie Platt Millie Platt is offline
Banned
 
Join Date: 22-03-2013
29 y/o Male from France
Posts: 579
Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.Millie Platt probably knows what they are talking about.
Re: How much Codeine metabolizes into Morpine?

i'm sure this has been covered about a million times but the rule of thumb is roughly 10% - give or take depending on metabolism.

some can't metabolise it at all.
  #3  
Old 22-06-2013, 20:53
Mindless Mindless is offline
Encrusted Member
 
Join Date: 23-02-2011
50 y/o Male from United Kingdom
Posts: 1,634
Blog Entries: 3
Mindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forumMindless is living in mutualistic symbiosis with drugs-forum
Points: 7,707, Level: 12 Points: 7,707, Level: 12 Points: 7,707, Level: 12
Activity: 0.2% Activity: 0.2% Activity: 0.2%
Re: How much Codeine metabolizes into Morpine?

The amount of codeine metabolised into morphine can vary. Some individuals appear to be extensive metabolisers, while others may be poor metabolisers. 6%-10% Caucasians, 2%-5% African Americans, and 1% Asians are poor metabolisers of CYP2D6 substrates such as codeine
Quote:
Patients who are CYP2D6 PMs (Poor Metabolisers) will not convert codeine to morphine and will have a reduced analgesic effect from codeine. When patients who are CYP2D6 EMs (Extensive Metabolisers) are administered a CYP2D6 inhibitor, they do not convert much codeine to morphine and have a minimal analgesic response to the codeine.
Ten percent seems to be the usual overall dose of morphine from codeine. Perhaps members of this group occupy points around the middle of a poor metaboliser-extensive metaboliser continuum.

Drug Interactions: insights and observations. Understanding an Important Variable in Patient Response. John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD, Pharmacy Times 2006.

It has been suggested that extensive metabolisers may convert codeine into morphine at an 'ultra-rapid' rate. CYP3AF inhibitors and renal insufficiency may lead to an increased risk of codeine toxicity for extensive metabolisers.

Codeine Intoxication Associated With Ultrarapid CYP2D6 Metabolism.

Chen et al (1991) make similar comments:
Quote:
There are several potentially important clinical implications of our findings. In healthy young subjects, there is unlikely to be unpredictable accumulation of codeine and codeine-6-glucuronide with chronic administration. This may not be the case, however, in patients with impaired renal function and in the elderly, in whom plasma codeine-6-glucuronide concentrations may be substantial and could contribute to adverse effects. Poor metabolisers of codeine may not derive any of the pharmacological effects associated with codeine.
Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.

Post Quality Evaluations:
Interesting data on ethnic variables

Last edited by Mindless; 20-07-2013 at 13:42. Reason: corrected hyperlink

Share this on:

Tags
codeine, morphine

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Cold Water Extraction of Opioids Alfa Wiki Articles 13 26-07-2012 01:09
Drug Info - Codeine trptamene Codeine 0 27-10-2007 01:34

» New Threads
Does this new blanket ban of legal...
Last post by DiabolicScheme
8 Replies, 69 Views
Question regarding Xanax
Last post by mr.M
6 Replies, 311 Views
Using small amount of meth for...
Last post by That
5 Replies, 454 Views
Day 3 without Hydrocodone and what...
Last post by Beenthere2Hippie
11 Replies, 984 Views
Severe sleep deprivation over 8...
Last post by DiabolicScheme
6 Replies, 274 Views
Question about Buprenorphine...
Last post by natey7
10 Replies, 721 Views
Saying Goodbye to My Sweet...
Last post by Ollie
21 Replies, 1,665 Views
Why did it burn so quick and taste...
Last post by That
5 Replies, 290 Views
An Absinthe by Any Other Name Does...
Last post by Beenthere2Hippie
0 Replies, 40 Views
More Than Half the South Yorkshire...
Last post by Isodimorphism
1 Replies, 43 Views
» New Wiki Articles
CBD

Sitelinks: Information:

All times are GMT +1. The time now is 18:55.


Copyright: SIN Foundation 2003 - 2014, All rights reserved