Someone I know has done a lot of this. They tell me that the effects are much more euphoric and borderline psychedelic
feeling. They have also done the straight oral dosing and it hasn't done much for them but make them a little out of it.
) leaves their noses extremely clogged for the night they do them and the morning after, probably because of it not being water-soluble, but the effects hit immediately after the insufflation
This leaves me to believe that it is at least partly soluble in water and perhaps the fillers in the powder are not, but I'm not positive.