Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News Chat
Go Back   Drugs Forum > DRUG-FORUMS > Amphetamine > Methamphetamine
Mark Forums Read
Register Tags

Notices

 
Thread Tools
  #1  
Old 28-03-2007, 18:53
machine_elf machine_elf is offline
Silver Member
 
Join Date: 06-02-2007
Male from United Kingdom
Posts: 174
machine_elf is a decent psychonaut.machine_elf is a decent psychonaut.
Points: 383, Level: 3 Points: 383, Level: 3 Points: 383, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Methamphetamine's mode of action

I was sure that methamphetamine solely affected the adrenal system (and possibly dopamine) but someone was claiming that its main method of action was that it released endorphins. I said that he was getting confused with opiates (as they are all converted into morphine in the brain which binds to endorphin receptors) but he was adamant that methamphetamine also affects endorphins. Could anyone pleaes shed light on the truth of methamphetamine's mode of action for me? Thanks.
  #2  
Old 28-03-2007, 19:41
Nicaine Nicaine is offline
Titanium Member
 
Join Date: 12-07-2004
51 y/o Male from USA - Rhode Island
Posts: 2,362
Nicaine must live here.Nicaine must live here.Nicaine must live here.Nicaine must live here.Nicaine must live here.Nicaine must live here.Nicaine must live here.
Points: 4,305, Level: 9 Points: 4,305, Level: 9 Points: 4,305, Level: 9
Activity: 0% Activity: 0% Activity: 0%
Re: Methamphetamine's mode of action

Ever heard of Google?

I'll add this much: If meth worked solely on the adrenal system, the high would be very unpleasant (jitters, anxiety, panic, fear, fight-or-flight stuff) rather than the much sought-after high that it is. Most of its positive effects come from its HUGE influence on the brain's dopamine level and associated mechanisms, but it may have some effect on endorphins as well... not sure.

P.S. Here's a starting point for ya.
  #3  
Old 29-03-2007, 16:36
machine_elf machine_elf is offline
Silver Member
 
Join Date: 06-02-2007
Male from United Kingdom
Posts: 174
machine_elf is a decent psychonaut.machine_elf is a decent psychonaut.
Points: 383, Level: 3 Points: 383, Level: 3 Points: 383, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: Methamphetamine's mode of action

Lol, cheers man.
  #4  
Old 30-03-2007, 21:11
izzy31 izzy31 is offline
Banned
 
Join Date: 16-09-2006
31 y/o Male from Turkmenistan
Posts: 460
izzy31 is a decent psychonaut.
Points: 215, Level: 2 Points: 215, Level: 2 Points: 215, Level: 2
Activity: 0% Activity: 0% Activity: 0%
Re: Methamphetamine's mode of action

brief explanation - not the most accurate or comprehensive, but the main idea is there


(meth)amphetamine inhibits dopamine reuptake (as well as delivers an initial stimulation of dopamine referred to as the "rush" or onset) causing the dopamine catcher (the thing that ends a dopamine-feeling) to become inhibited, or impaired, sort of like he's had too many to drive - he's inhibited and unable to do his job which is catching dopamine. so the dopamine is recycled and remaining circulation (proper term would be "flow" i guess). a persons actions feel rewarding (good). it usually requires the person to do things to feel good - and those things are usually fun.
  #5  
Old 31-03-2007, 00:06
Benzeneringz Benzeneringz is offline
Titanium Member
 
Join Date: 18-05-2006
29 y/o Male from United States
Posts: 179
Benzeneringz really adds to the discussion.Benzeneringz really adds to the discussion.Benzeneringz really adds to the discussion.Benzeneringz really adds to the discussion.Benzeneringz really adds to the discussion.Benzeneringz really adds to the discussion.
Points: 986, Level: 4 Points: 986, Level: 4 Points: 986, Level: 4
Activity: 0% Activity: 0% Activity: 0%
Re: Methamphetamine's mode of action

Methamphetamine causes dopamine and norepinephrine to leak out of their storage vesicles and into the synaptic cleft. To a lesser extent, methamphetamine inhibits the DAT (dopamine transporter) that is responsible for the reuptake of the neurotransmitter back into the axon; simply put, it is a dopamine reuptake inhibitor (but to a lesser extent than methylphenidate or cocaine). Methamphetamine also inhibits monoamine oxadise to a small degree, which prevents the dopamine and norepinephrine from being deactivated in the synapse. These three pharmacological actions cause the dopamine and norepinephrine to remain in the synaptic cleft for much longer than normal, and thus stimulates their respected receptors for a longer period of time than normal. The main euphoric qualities of methamphetamine are believed to be the release of dopamine in the nucleus accumbens shell as well as the core. Since endorphins indirectly affect this part of the brain, I can see how one would conclude that methamphetamine releases endorphins. But it's just not true because it is not a ligand for any subtype of opioid receptor (mu, kappa, delta, omega).

Share this on:

Tags
amphetamine, endorphin, endorphins, meth, methamphetamine, methamphetamines

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Early-warning system on new synthetic drugs Alfa Law and order 7 14-04-2013 16:56
Pharmacology - Benzodiazepines - Mode of Action? pema Benzodiazepines 0 30-03-2012 14:23
Sublingual mode of action kapten Pharmacology 23 20-02-2011 21:20
Pharmacology of Common Recreational Drugs Nnizzle Pharmacology 13 27-01-2010 12:26
Dissociatives - mode of action Dalfir Dissociatives 19 08-08-2007 15:30

» New Threads
New user wanting to say hello!
Last post by PhilthyPhil
6 Replies, 305 Views
injecting meth in cigarettes
Last post by StayFit86
13 Replies, 14,389 Views
Crack, melt or not to melt, that...
Last post by Wolfykins
15 Replies, 20,356 Views
Major Keks- My S/O Smoked a...
Last post by The great barfowski
0 Replies, 48 Views
Tramadol Cured my chronic...
Last post by amok666paradox
2 Replies, 118 Views
Holy mother of wolves - never...
Last post by Wolfykins
0 Replies, 58 Views
Why I personally think DXM is the...
Last post by ladywolf2012
5 Replies, 342 Views
Today I think I fucked up pretty...
Last post by AKA_freckles
22 Replies, 1,399 Views
Help me find my visuals please
Last post by Ogasi
1 Replies, 133 Views
New Guy going Cold Turkey. Need...
Last post by leo nard
46 Replies, 2,453 Views
» New Wiki Articles
GBL

Sitelinks: Information:

All times are GMT +1. The time now is 11:42.


Copyright: SIN Foundation 2003 - 2014, All rights reserved