Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News Chat
Go Back   Drugs Forum > DRUG-FORUMS > Research Chemicals
Mark Forums Read
Register Tags

Notices

Research Chemicals Piperazines, Phenethylamines, Tryptamines & other designer drugs.

 
Thread Tools
  #1  
Old 20-12-2006, 01:34
radiometer radiometer is offline
bananadine addict
 
Join Date: 13-04-2005
Male from United States
Posts: 3,312
Blog Entries: 1
radiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forum
Points: 7,582, Level: 12 Points: 7,582, Level: 12 Points: 7,582, Level: 12
Activity: 0.1% Activity: 0.1% Activity: 0.1%
STUDY: monoamine transmission effects of various chemicals

I found this posted elsewhere today. This will be published in the European Journal of Pharmacology. It would be fantastic if comeone could come up with the full text of this study:

Quote:
The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain

In Press, Accepted Manuscript, Available online 12 December 2006
Fumiko Nagai, Ryouichi Nonaka, Kanako Satoh and Hisashi Kamimura


We developed a reproducible, simple, and small-scale method for determining the re-uptake and release of monoamines (dopamine, serotonin (5-HT) and norepinephrine), using rat brain synaptosomes. These assays were then applied to study the effects of different kinds of nonmedically used psychoactive drugs on monoamine re-uptake and release. The phenethylamine derivatives, 4-fluoroamphetamine, 2-methylamino-3,4-methylene- dioxy-propiophenone (methylone), 1-(1,3-benzodioxol-5-yl)-2-butanamine (BDB), and N-methyl-1-(1,3- benzodioxol-5-yl)-2-butanamine (MBDB), had strong inhibitory effects on the re-uptake of dopamine, 5-HT and norepinephrine. 4-Fluoroamphetamine, methylone and BDB also strongly increased the release of the three monoamines, but MBDB increased 5-HT and norepinephrine release, but had little effect on dopamine release. However, 2,5-dimethoxy-4-iodophenethylamine (2C-I), 2,5-dimethoxy-4-ethylphenethylamine (2C-E), 2,5-dimethoxy-4-chlorophenethylamine (2C-C), 2,4,5-trimethoxyamphetamine (TMA-2) and 2,4,6-trimethoxyamphetamine (TMA-6), which are methoxylated phenethylamine derivatives, slightly influenced the re-uptake and release of monoamines. α-Metyltryptamine (AMT), a tryptamine derivative, was one of the strongest re-uptake inhibitors and releasers of the three monoamines. The tryptamine derivative, 5-methoxy-α-methyltryptamine (5-MeO-AMT), also strongly inhibited re-uptake and increased the release of the three monoamines. N,Ndipropyltryptamine (DPT), 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), 5- methoxy-N,N-methylisopropyltryptamine (5-MeO-MIPT), and 5-methoxy-N,Ndimethyltryptamine (5-MeO-DMT) inhibited monoamine re-uptake, but had a few effects on monoamine release. 1-(3-Chlorophenyl)piperazine (3CPP) and 1-(methoxyphenyl)piperazine (4MPP), which are piperazine derivatives, inhibited monoamine re-uptake and accelerated their release. The results suggest that some designer drugs strongly act on the central nerve system to the same extent as restricted drugs.
The person who originally posted this apparently had access to the full article, and included the researchers' conclusion:

Quote:
We propose that these drugs be strongly restricted to keep society and its people healthy.


Post Quality Evaluations:
Good find!

Last edited by radiometer; 20-12-2006 at 01:41.
  #2  
Old 20-12-2006, 01:54
Nagognog2 Nagognog2 is offline
Banned
 
Join Date: 01-02-2005
Male
Posts: 7,173
Nagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPACNagognog2 must think in IUPAC
Points: 3,186, Level: 8 Points: 3,186, Level: 8 Points: 3,186, Level: 8
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

Excellent find. This backs many of my findings perfectly. Please post the full article - anyone - if you can find it.

Last edited by Nagognog2; 20-12-2006 at 23:51.
  #3  
Old 20-12-2006, 04:23
Alfa Alfa is offline
Import loop gazer
Administrator
 
Join Date: 14-01-2003
100 y/o Male from Netherlands
Posts: 28,509
Blog Entries: 6
Alfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond repute
Points: 84,915, Level: 41 Points: 84,915, Level: 41 Points: 84,915, Level: 41
Activity: 28.6% Activity: 28.6% Activity: 28.6%
Re: STUDY: monoamine transmission effects of various chemicals

That article is hard to find, but would be very nice to have.
  #4  
Old 20-12-2006, 17:10
Platinum Member
 
Join Date: 12-04-2005
Male from Australia
Posts: 1,136
nanobrain must live here.nanobrain must live here.nanobrain must live here.nanobrain must live here.nanobrain must live here.nanobrain must live here.nanobrain must live here.
Points: 1,136, Level: 5 Points: 1,136, Level: 5 Points: 1,136, Level: 5
Activity: 0.1% Activity: 0.1% Activity: 0.1%
Re: STUDY: monoamine transmission effects of various chemicals

as if there was any doubt, eh gang?
  #5  
Old 20-12-2006, 21:59
Rush Rush is offline
Titanium Member
 
Join Date: 30-11-2006
Male from Switzerland
Posts: 155
Rush is a decent psychonaut.Rush is a decent psychonaut.
Points: 402, Level: 3 Points: 402, Level: 3 Points: 402, Level: 3
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

yeah, finally i see some pharmachology research about 5-meo-amt!

how to find old articles that are not online? is there some way? at least abstract because there isnt even that!

i'm interested in
Synthesis and some pharmacological properties of alpha-methyltryptamine and its 5-methoxy derivative.

TERZIAN AG
SAFRASBEKIAN RR
SUKASIAN RS
TATEVOSIAN GT

and also very important to me:
Kantor RE, Dudlettes SD, Shulgin AT.

5-methoxy-alpha-methyltryptamine (alphs, o-dimethylserotonin), a hallucinogenic homolog of serotonin.
Biol Psychiatry. 1980 Apr;15(2):349-52. No abstract available.
PMID: 7417623 [PubMed - indexed for MEDLINE]

thank you for every help!
  #6  
Old 20-12-2006, 23:47
Alfa Alfa is offline
Import loop gazer
Administrator
 
Join Date: 14-01-2003
100 y/o Male from Netherlands
Posts: 28,509
Blog Entries: 6
Alfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond repute
Points: 84,915, Level: 41 Points: 84,915, Level: 41 Points: 84,915, Level: 41
Activity: 28.6% Activity: 28.6% Activity: 28.6%
Re: STUDY: monoamine transmission effects of various chemicals

You can request articles here: Help from people with Medline access requested
  #7  
Old 21-12-2006, 02:24
London_Bloke London_Bloke is offline
Gold Member
 
Join Date: 21-07-2006
Male
Posts: 268
London_Bloke must live here.London_Bloke must live here.London_Bloke must live here.London_Bloke must live here.London_Bloke must live here.London_Bloke must live here.London_Bloke must live here.London_Bloke must live here.
Points: 1,090, Level: 5 Points: 1,090, Level: 5 Points: 1,090, Level: 5
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

Good find - I'd really like to see the whole thing...
  #8  
Old 21-12-2006, 03:41
NeonCortex NeonCortex is offline
Account Awaiting Email Confirmation.
 
Join Date: 27-09-2006
Male
Posts: 118
NeonCortex is a decent psychonaut.NeonCortex is a decent psychonaut.
Points: 141, Level: 1 Points: 141, Level: 1 Points: 141, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

It's uploaded under "Research Chemicals".

Post Quality Evaluations:
Great find with that article
points for your posting the PDF
Brilliant find. Very interesting document.
  #9  
Old 21-12-2006, 04:17
radiometer radiometer is offline
bananadine addict
 
Join Date: 13-04-2005
Male from United States
Posts: 3,312
Blog Entries: 1
radiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forumradiometer is living in mutualistic symbiosis with drugs-forum
Points: 7,582, Level: 12 Points: 7,582, Level: 12 Points: 7,582, Level: 12
Activity: 0.1% Activity: 0.1% Activity: 0.1%
Re: STUDY: monoamine transmission effects of various chemicals

You've got me excited! But I'm a dolt and can't find it - can you please link to it? Thanks.
  #10  
Old 21-12-2006, 12:35
Alfa Alfa is offline
Import loop gazer
Administrator
 
Join Date: 14-01-2003
100 y/o Male from Netherlands
Posts: 28,509
Blog Entries: 6
Alfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond repute
Points: 84,915, Level: 41 Points: 84,915, Level: 41 Points: 84,915, Level: 41
Activity: 28.6% Activity: 28.6% Activity: 28.6%
Re: STUDY: monoamine transmission effects of various chemicals

I just approved it. Most interesting: Research Chemicals
  #11  
Old 22-12-2006, 01:35
El Calico Loco El Calico Loco is offline
Account Awaiting Email Confirmation.
 
Join Date: 30-08-2006
40 y/o Male from United States
Posts: 1,166
El Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPAC
Points: 2,468, Level: 7 Points: 2,468, Level: 7 Points: 2,468, Level: 7
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

Pardon my amateurness, but I want to make sure I understand:

The 2C's are mild dopamine, serotonin, and norepinephrine releasers and reuptake imhibitors, while 5-MeO-DMT is a weak releaser but a somewhat stronger reuptake inhibitor?

Do MAOIs work the same way? I thought (for whatever reason) that the action of MAOIs took place in the GI tract rather than the brain, preventing things from getting digested properly (or causing other things to get digested the way you want them to).

I suppose this says something about the use of tobacco and DXM with these RC's...tobacco smoke inhibits the reputake of dopamine, IIRC. DXM supposedly inhibits both dopamine and serotonin.


ECL
  #12  
Old 22-12-2006, 01:44
Alfa Alfa is offline
Import loop gazer
Administrator
 
Join Date: 14-01-2003
100 y/o Male from Netherlands
Posts: 28,509
Blog Entries: 6
Alfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond repute
Points: 84,915, Level: 41 Points: 84,915, Level: 41 Points: 84,915, Level: 41
Activity: 28.6% Activity: 28.6% Activity: 28.6%
Re: STUDY: monoamine transmission effects of various chemicals

MAOI's are something different but related. MAOI's inhibit the oxidating of the mono amines mentioned above(dopamine, serotonin, and norepinephrine). In other words: MAOI's potentiate mono amines.
And yes, mono amines are present in the GI tract. But mono amines are not limited to the Brain.
  #13  
Old 22-12-2006, 03:01
pankreeas pankreeas is offline
Gold Member
 
Join Date: 22-11-2005
96 y/o Male
Posts: 476
pankreeas probably knows what they are talking about.pankreeas probably knows what they are talking about.pankreeas probably knows what they are talking about.pankreeas probably knows what they are talking about.pankreeas probably knows what they are talking about.
Points: 1,459, Level: 5 Points: 1,459, Level: 5 Points: 1,459, Level: 5
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

so by potentiating do you mean maoi's aid in getting mono amines across the blood/brain barrier at a faster rate? and this is a negative thing?
  #14  
Old 22-12-2006, 11:30
Alfa Alfa is offline
Import loop gazer
Administrator
 
Join Date: 14-01-2003
100 y/o Male from Netherlands
Posts: 28,509
Blog Entries: 6
Alfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond reputeAlfa is a true resource and beyond repute
Points: 84,915, Level: 41 Points: 84,915, Level: 41 Points: 84,915, Level: 41
Activity: 28.6% Activity: 28.6% Activity: 28.6%
Re: STUDY: monoamine transmission effects of various chemicals

I mean that where part of the available mono amines would normally be oxidated, with the activity of MAOI's less mono amines get oxidated and thus more mono amines can affect the body.
  #15  
Old 22-12-2006, 18:05
El Calico Loco El Calico Loco is offline
Account Awaiting Email Confirmation.
 
Join Date: 30-08-2006
40 y/o Male from United States
Posts: 1,166
El Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPACEl Calico Loco must think in IUPAC
Points: 2,468, Level: 7 Points: 2,468, Level: 7 Points: 2,468, Level: 7
Activity: 0% Activity: 0% Activity: 0%
Re: STUDY: monoamine transmission effects of various chemicals

So...5-MeO-AMT strongly inhibits reuptake while encouraging release at the same time. Could this be why some people have such an adverse reaction to it? Self-induced serotonin syndrome, perhaps? While others who have too little serotonin to begin with (naturally, or because they've been using too many drugs lately) have no such reaction?


ECL

Share this on:

Tags
alpha-methyltryptamine, drugs, monoamine, psychoactive, psychoactive drugs

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Interesting scholarly drug facts rxbandit Pharmacology 26 27-05-2015 01:07
Drug info - St. Johns Wort FAQ - usage, dosage, effects etc 0utrider Antidepressants 3 15-05-2014 17:27
Legal Herbs and Chemicals OneDiaDem Herbal Ecstasy 37 21-07-2011 16:46
Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism Bajeda DXM 13 08-07-2009 01:53
Study of MDMA on XTC-VIRGINS! FUNNY... Scientists Corrupting the Subjects! :) Richard_smoker Ecstasy & MDMA 7 28-05-2006 13:07

» New Threads
Messed Up Chakras after long use..
Last post by Torpito
7 Replies, 472 Views
Dug myself another hole - Suboxone...
Last post by Cmenot
3 Replies, 134 Views
Clonazepam withdrawal after daily...
Last post by TheCrystallineCook
3 Replies, 71 Views
why do poppies produce morphine
Last post by bluenarrative
6 Replies, 284 Views
Trying to stay sane while my son...
Last post by Cmenot
1 Replies, 148 Views
O.P.M.S. Kratom extract pills...
Last post by seaturtle
4 Replies, 168 Views
could I fail an etg from doing a...
Last post by TheCrystallineCook
12 Replies, 199 Views
My girlfriend is on heroin (again)
Last post by redwhiteandblue
24 Replies, 1,432 Views
Anamorph Morphine Sulfate BP 30MG...
Last post by OzGuy
1 Replies, 118 Views
Acid while having schizophrenia?
Last post by jazzyj9
6 Replies, 213 Views
» New Wiki Articles
THC
CBN

Sitelinks: Information:

All times are GMT +1. The time now is 04:23.


Copyright: SIN Foundation 2003 - 2014, All rights reserved