Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News Chat
Go Back   Drugs Forum > DRUG-FORUMS > Various drugs not covered by other forums > Nootropics
Mark Forums Read
Register Tags

Notices

Nootropics Smartdrugs, Brain boosters & Cognitive enhancers.

 
Thread Tools
  #1  
Old 18-03-2016, 02:30
Bro Smurf66 Bro Smurf66 is offline
Silver Member
 
Join Date: 30-03-2015
Male from United States
Posts: 96
Bro Smurf66 is a decent psychonaut.Bro Smurf66 is a decent psychonaut.
Points: 208, Level: 2 Points: 208, Level: 2 Points: 208, Level: 2
Activity: 0.8% Activity: 0.8% Activity: 0.8%
**NEW** F-Phenibut Experience

I ordered some F-Phenibut the first day it came out (from the company I usually order from). It is said to be around 5-10x more potent than Phenibut HCL. I tested a 200mg dose of F-Phenibut, and it felt like 2-3 grams of Phenibut HCL. The onset started to come on at the 1 hour mark, and gradually 'built up' until it peaked at 3-4 hours after dosing. The total duration was about 8-9 hours. It seemed like it was less stimulating and more sedating than Phenibut HCL, but I'm 95% sure it was due to the potency: 200mg F-Phenibut felt like 2-3 grams Phenibut HCL, while I usually take 1.2 grams Phenibut HCL, so this was probably the reason why I was more sedated.

Today (2nd time testing) I tried 130 mg F-Phenibut. It felt like my normal 1.2 gram dose of Phenibut HCL, although it didn't hit me as fast as the HCL, which usually gives me an energy boost and makes me super talkative. It sort of reminds me of a cross between Phenibut HCL and F.A.A. in terms of duration and intensity.

Not many people have tested this compound yet, so I thought I'd let our DF family know about it! Feel free to ask any questions. It might take me a few days to respond, so please be patient. Thanks!
  #2  
Old 18-03-2016, 19:35
Adas Adas is offline
Silver Member
 
Join Date: 22-08-2013
21 y/o Male from Slovakia
Posts: 1,452
Adas probably knows what they are talking about.Adas probably knows what they are talking about.Adas probably knows what they are talking about.Adas probably knows what they are talking about.Adas probably knows what they are talking about.
Points: 650, Level: 3 Points: 650, Level: 3 Points: 650, Level: 3
Activity: 37.6% Activity: 37.6% Activity: 37.6%
Re: **NEW** F-Phenibut Experience

Fluorinated phenibut? That would look similar to Baclofen. Baclofen is a GABA-B agonist, Phenibut is mostly Ca2+ channel blocker. This could explain the difference.
  #3  
Old 19-03-2016, 05:51
Jonathan James Jones Jonathan James Jones is offline
Newbie
 
Join Date: 15-08-2015
Male from United States
Posts: 57
Jonathan James Jones should urgently read the rules & received reputation comments.
Re: **NEW** F-Phenibut Experience

Quote:
Originally Posted by Adas View Post
Baclofen is a GABA-B agonist, Phenibut is mostly Ca2+ channel blocker.
I don't know man, I'd say phenibut's got a whole of GABA agonism going on. It sure does feel like it. I know when my GABA system's going - the effects are unmistakable. At least for the first 2 or 3 hours phenibut feels very benzo-ish....at Hour 4 though it shifts course and feels like I'm surging with adrenaline.
  #4  
Old 20-03-2016, 00:27
Bro Smurf66 Bro Smurf66 is offline
Silver Member
 
Join Date: 30-03-2015
Male from United States
Posts: 96
Bro Smurf66 is a decent psychonaut.Bro Smurf66 is a decent psychonaut.
Points: 208, Level: 2 Points: 208, Level: 2 Points: 208, Level: 2
Activity: 0.8% Activity: 0.8% Activity: 0.8%
Re: **NEW** F-Phenibut Experience

Yeah Phenibut is definitely a GABA-B agonist, and is also a potent VGCC (Voltage-Gated Calcium Channel) Blocker, similar to Gabapentin and Pregabalin (and Baclofen to some extent).

Just because Phenibut is a weaker Gaba-B agonist than Baclofen by weight doesn't necessarily mean it's mostly a Ca2+ channel blocker.

Baclofen is "β-(4-chlorophenyl)-γ-aminobutyric acid", while Phenibut is β-(phenyl)-γ-aminobutyric acid. The only difference in the molecular structure of Baclofen and Phenibut is that Baclofen has a Chlorine tacked on the end of the Phenibut structure.

F-Phenibut is 'Fluorinated' Phenibut, while Baclofen is like 'Chlorinated' Phenibut.

@jonjones (nice name haha)-- I wonder if your body realizes that there's above normal levels of GABA in your system after the 4 hour mark and your body releases norepinephrine to counteract it while the GABA wears off, leaving you more stimulated? Just a theory. The human body is always trying to reach homeostasis!
  #5  
Old 20-03-2016, 13:15
Adas Adas is offline
Silver Member
 
Join Date: 22-08-2013
21 y/o Male from Slovakia
Posts: 1,452
Adas probably knows what they are talking about.Adas probably knows what they are talking about.Adas probably knows what they are talking about.Adas probably knows what they are talking about.Adas probably knows what they are talking about.
Points: 650, Level: 3 Points: 650, Level: 3 Points: 650, Level: 3
Activity: 37.6% Activity: 37.6% Activity: 37.6%
Re: **NEW** F-Phenibut Experience

"Subsequent research has found that phenibut also binds to and potently blocks α2δ subunit-containing voltage-gated calcium channels (VGCCs), similarly to gabapentin and pregabalin. Both enantiomers of phenibut show this action with similar efficacy. Moreover, the R-enantiomer possesses five-fold greater affinity for this site relative to the GABAB receptor, while the S-enantiomer does not bind to the GABAB receptor at all. As such, phenibut is likely to have much greater effect on α2δ subunit-containing VGCCs than on the GABAB receptor." - Wikipedia

Here you have it. The Wikipedia article had been expanded a lot lately.

Share this on:

Tags
anxiety, benzo effects, downers, experience, nootropic, phenibut, phenibut dosage, phenibut experiences

Thread Tools


Similar Threads
Thread Thread Starter Forum Replies Last Post
Drug info - Phenibut Guidelines; The Ropes, from top to bottom. natey7 Nootropics 43 12-08-2016 22:34
The psychedelic crisis: bad trip Joe-(5-HTP) Wiki Articles 28 18-06-2016 23:07
Psilocybe Fanaticus’s encounter with the law, for shrooms. Alfa Law and order 2 16-03-2013 01:50
Opinions - Baclofen, Phenibut...similarities/differences to GHB? Troppo GHB 6 27-06-2012 15:36
Phenibut Experience fuzzymofo Nootropics 5 10-06-2005 19:33


Sitelinks: Information:

All times are GMT +1. The time now is 05:28.


Copyright: SIN Foundation 2003 - 2014, All rights reserved