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  #1  
Old 04-01-2017, 17:48
Beenthere2Hippie Beenthere2Hippie is offline
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Painkillers Based on Medicinal Cannabis Showing "Gold-Standard" Promise

Researchers at Leiden University led by Mario van der Stelt (Leiden Institute for Chemistry) have set 'gold standards' for developing new painkillers based on the medicinal effects of cannabis. Publication in Nature Communications.

Medicinal marihuana

Medicinal marihuana is in frequent use as a painkiller, but its psycho-active side-effects are a major disadvantage. The pharmaceutical industry is desperately seeking a synthetic form of cannabis that inhibits inflammation and pain, but without the high. Leiden researchers have now brought the development of such drugs a step closer.

In an article in Nature Communications they set out 'gold standards' for the use of reference substances, to improve trials with synthetic cannabis.

Many of the clinical trials carried out to date with with synthetic cannabis have failed, with no measurable effect being recorded in patients. One of the causes of these failures can be found in the pre-clinical lab, during testing with animals. Substances are often used in these tests whose biochemical and molecular-pharmaceutical effects have never been properly characterised.

As a result, there have been a lot of contradictory publications on research findings, the results of which cannot be reproduced. This is having a major effect on the allocation of research funding, the use of animal testing and the exposure of patients to non-active substances.

International and public-private collaboration

Marjolein Soethoudt, a PhD candidate in Van der Stelt's research group, studied together with 12 international academic groups, the National Institute of Health (US) and pharmaceuticals concern Hoffman-LaRoche (Switzerland), the 18 most commonly used reference substances, including the psychoactive ingredient in marihuana, Δ9-THC. They carried out their studies under standardised conditions in 36 different tests, to analyse the molecular pharmacological characteristics of the substances. They hoped to be able to identify the most suitable reference sustances for the research on synthetic cannabis. The research led to three 'gold standards' that should make it possible to give an impetus to the development of new painkillers and anti-inflammatories.

Cannabinoid CB2 receptor

Δ9-THC binds to two types of proteins in the human body: the cannabinoid CB1 receptor in the brain and the cannabinoid CB2 receptor in the immune system. Activating the CB1 receptor in the brain makes you high, while activating the CB2 receptor has an anti-inflammatory effect. The three 'gold standards' are molecules that are highly selective in activating only the CB2 receptor and ignoring the CB1 receptor.

These three gold standards also appeared to cause the fewest side-effects, nor did they give the mice a high. Earlier studies have shown that these substances do have an analgesic and anti-inflammatory effect. The researchers advise that these three gold standards should be used in future in research on new medicines that rely on the activation of the cannabinoid CB2 receptor for their effectiveness.

Source: Leiden University​



Leiden University via Medical Net/Jan. 4, 2017
http://www.news-medical.net/news/201...-cannabis.aspx
Illustration: Yekatrina Kadyshevskaya, Stevens Laboratory
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  #2  
Old 04-01-2017, 22:20
aemetha aemetha is offline
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Re: Painkillers Based on Medicinal Cannabis Showing "Gold-Standard" Promise

I'm not an expert on this, perhaps shampoo or someone equally knowledgeable on the workings of cannabinoids could weigh in on it if I'm way off base.

My understanding of the working of CB1 was that it was implicated in the pain response through activity in the spine and periaquaductal gray via inhibition of GABA and glutamate. Wouldn't excluding these receptors in cannabinoid based medications therefore water down any analgesic benefits from cannabinoids?
  #3  
Old 05-01-2017, 12:34
Gradois Gradois is offline
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Re: Painkillers Based on Medicinal Cannabis Showing "Gold-Standard" Promise

Quote:
The pharmaceutical industry is desperately seeking a synthetic form of cannabis that inhibits inflammation and pain, but without the high
There already exist a synthetic form of cannabis that inhibits inflammation and pain, but without the high and it has been in widespread use for over one hundred years: Paracetamol

From pubmed.gov id=17227290 (Publication from 2006):
Quote:
Although paracetamol has been used clinically for more than a century, its mode of action has been a mystery until about one year ago, when two independent groups (Zygmunt and colleagues and Bertolini and colleagues) produced experimental data unequivocally demonstrating that the analgesic effect of paracetamol is due to the indirect activation of cannabinoid CB(1) receptors. In brain and spinal cord, paracetamol, following deacetylation to its primary amine (p-aminophenol), is conjugated with arachidonic acid to form N-arachidonoylphenolamine, a compound already known (AM404) as an endogenous cannabinoid

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