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Swim has recently been exposing himself to a variety of substances for testing with the common denominator in every test being the ingestion of 150 mg dxm anywhere from 1-4 hours before each experiment.
So far it definitely potentiates opiates, but swim found it seems to go much beyond just the opiate class. The fact of the matter is that on every occasion the dxm has added to the experience and not once failed to make it's presence known in swims bloodstream.
A short summary:
-Very strong synergy potential for many classes of drugs
-Dxm never exceeded 150mg although the temptation was strong.
-Dose dependent in the sense that each substance is much more effectively potentiated when taken at the right time. Perfect example being cocaine, if insufflated 1 hour after taking the dxm effects are mildly noticed however after 2-3 hours the cocaine hits much harder in the euphoria department.
If dxm is taken after most substances then the effects are almost always overriden even with higher doses of dxm.
The potentiation of opiates is not something new to swim as he almost always uses dxm to smooth out his experience 1-2 hours before punching in the timeclock for his shift with codeine. But the last few weeks has allowed for much experimenting with dxm in conjunction with the following:
Cocaine - very noticeable synergy Marijuana - ditto
Bzp - needs further testing
Codeine - the most synergy with dxm out of any other class tried Alcohol - pass out central ZZzzzzzz
The body builds tolerance to DXM very very quickly. IMO one should wait at least a couple weeks, if not a month, between dosing. At the lower end of the recommended recreatonal dose if one were to try 150 mg DXM and wanted to trip the day after, for some people the dose may be as high as 600-1000mg in order to achieve the same effect (I suggest waiting rather than increasing dose).
A quick search for "DXM tolerance" may turn up good results on this matter.
150mg may potentiate other substances even further if there is no tolerance to DXM, which the body is likely producing. In SWAT's experience it has taken at least 3 weeks to feel like there is no tolerance and SWAT is back at baseline.
So for a more accurate experiment, maybe a few weeks between each potentiation would be in order? That's up to SWIP but IMO, it probably would have stronger potentiation effects.
Also, DXM can prevent/lower opiate tolerance, which might make sense for it's potentiation effect. This may be relevant.
He definitely advises sticking to low amounts of DXM. He had a difficult experience with DXM and codeine, as detailed here. He's found that even as little as 50mg of DXM can have a pronounced effect on psychedelics, and generally not in a good way. Taking a low dose of DiPT the day after a 3rd-plateau DXM trip was extremely unpleasant.
He agrees that the timing is important. Some drugs use the same enzyme family as dex, so one might have a very different experience depending on which drug one takes first. Cannabis is notable in this regard, as he's read that it deactivates the family necessary for processing DXM. He can say from personal experience that smoking cannabis after reaching the peak of a DXM trip is great, while smoking cannabis right after taking DXM leads to unpleasant semi-psychosis. Depending on the amount smoked.
There's some danger in combining DXM and alcohol due to the possibility of repiratory depression, but I think one would have to combine large amounts of both for it to be that dangerous. Using small amounts of one with a moderate amount of the other has been safe in Swim's experience.
I am curious about your contention that it's hard on the liver, however. Could you elaborate, maybe provide a link to a source of information?
I have no link and I don't claim to have any medical expertise. But i've heard many places that alcohol is hard on the liver and I've also heard many places that DXM is hard on the liver and kidneys. So taking two things which both have the same negative effect on a specific organ could be a possible health hazard. But in small amounts it may be insignificant.
The only time SWIM has thrown up from a drug other than alcohol was recently when he attempted to potentiate insufflated oxycodone with dxm. He'd tried this oxy/dxm combo before with seemingly no effect, and this time only combined 60mg of dxm with 30mg of oxy (a light dose for SWIM) and ended up vomiting. He's tried dxm/opiate combos before as well and never had any success, but from what others have said your mileage may vary.