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Drug combinations About mixing drugs.

 
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  #1  
Old 30-08-2007, 03:54
Orchid_Suspiria Orchid_Suspiria is offline
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Is trazodone and diphenhydramine a safe combination for sleep?

Swim was wondering if 125 mg's of diphenhydramine and 50 mg's of trazodone would be a safe combination to get to sleep?Do any swiy's have any experience with this combination?
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Old 06-09-2007, 22:56
pixplzthx pixplzthx is offline
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Re: Is trazodone and diphenhydramine a safe combination for sleep?

Well.... Based on the information available to me (google), I'd just recommend calling a pharmacy.

No, Really. I've done it. They love to answer questions.

My concern is whether or not the moderate (to none) SSRI effects of either drug would expo-tentiate (exponentially potentiate, I just made that up). Based on what I'm reading (at Wiki and rxlist) that shouldn't happen.

But when you are dealing with death, it never hurts to ask a professional.

Also, they act on different areas of the brain. Trazodone is acting on the 5-HT receptor and diphenhydramine is acting on histamine h-1 receptor.

Last edited by pixplzthx; 06-09-2007 at 23:03. Reason: forgot a /
  #3  
Old 07-09-2007, 01:10
kareena kareena is offline
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Re: Is trazodone and diphenhydramine a safe combination for sleep?

As pixplzthx says it couldn't hurt to call a pharmacy...
I wouldn't expect that combo to cause any problems though, SWIM has used higher than therapeutic doses of diphenhydramine with mirtazapine (remeron) without consequence (other than the desired: sleep). I know mirtazapine isn't trazodone but they do have some similar mechanisms of action.

Last edited by kareena; 07-09-2007 at 01:20.

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benadryl, dipenhydramine, diphenhydramine, diphenhydramine combinations, insomnia, trazadone, trazodone

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