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  #1  
Old 27-10-2007, 00:18
Ellis D. Ellis D. is offline
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Potentiating Buprenorphine

Good Day,

SWIM was wondering if there is anything that will potentiate buprenorphine? SWIM has hydroxyzine, promethazine, DXM, tums, and grapefruit juice.

Thanks!
  #2  
Old 07-11-2007, 20:19
Orchid_Suspiria Orchid_Suspiria is offline
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Anyways of potentating suboxone?

Is there anyway to make the suboxone experience abit more euphoric?Would grapefruit juice work with suboxone the way it does with methadone and other opiates?Swim figures since he is on suboxone he may aswell make the most of it.
  #3  
Old 08-11-2007, 02:00
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Re: Anyways of potentating suboxone?

Since suboxone is used sublingually I don't know think the grapefruit juice would work, because the sub isn't in your stomach (where the juice goes).
  #4  
Old 09-11-2007, 12:18
Orchid_Suspiria Orchid_Suspiria is offline
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Re: Anyways of potentating suboxone?

Would antihistamines potentate it?
  #5  
Old 09-11-2007, 20:15
jerbles jerbles is offline
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Re: Anyways of potentating suboxone?

Around these parts, people use diphenhydramine to cut H with, and swim always get a noticeably stronger nod when injecting it. I don't know if it would work orally, though. Plus, I think diphenhydramine is more of sleep aid than an antihistamine.
  #6  
Old 14-11-2007, 07:14
Orchid_Suspiria Orchid_Suspiria is offline
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Re: Anyways of potentating suboxone?

Diphenhydramine is most definitely an antihistamine afterall it's Benadryl.And the sleepaid properties of antihistamines is the qualities that make them potentate opiates from what swim understands.
  #7  
Old 03-01-2008, 03:20
kailey_elise kailey_elise is offline
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Re: Potentiating Buprenorphine

*bump*

same question.

~Kailey_Elise
  #8  
Old 10-01-2008, 23:04
lexifer lexifer is offline
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Re: Potentiating Buprenorphine

swim knows of two things that potentiate opiates. grapefruit juice (or a grapefruit) some time before the opiate is consumed will potentiate the effects. and sometimes swim takes an antihistamine like diphenhydramine (benadryl) or hydroxyzine to potentiate effects as well.

promethazine would probably result in an increased sedative effect when mixed with opiates.

tums wont potentiate at all.

and swim would prob stay away from the dxm while doing opiates due to stomach discomfort.

swim would guess that the grapefruit juice or some type of antihistamine would be swiy's best bet in potentiating the buprenorphine.
  #9  
Old 27-01-2008, 01:07
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Re: Potentiating Buprenorphine

Tums neutralise the stomach's acids and raises the pH of the stomach's solution to basic levels, which turns the opioid into it's freebase making it insoluble and precipitate out, forcing it to the outer edges of the stomachs content, where it comes in contact with the stomach lining where it's rapidly absorbed. This potentiation trick can also be used for amphetamines.
  #10  
Old 31-01-2008, 21:44
Orchid_Suspiria Orchid_Suspiria is offline
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Re: Potentiating Buprenorphine

Give this quest up unless swiy is an infrequent opiate user,then buprenorphine may have some value.Otherwise it is the worse stuff ever created.It feels toxic actually,swim knows that it is far worse on the body than any other opiate but the powers that be would rather have you destroy your body than actually feel good.
  #11  
Old 23-03-2008, 05:19
Brettfavor Brettfavor is offline
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Re: Potentiating Buprenorphine

Buprenorphine is TOXIC? Methadone is toxic....addiction is toxic.....Buprenorphine allows you to feel NORMAL...no withdrawals and a clear head.


Buprenorphine feels the cleanest out of any opiate IMO. Now swim doesn't slam it so that may be a different story but taken as directed sublingually it is as clean as they come.

Opiate naive people can get high off it because it is strong as shit. But it is a partial agonist/partial antagonist so it won't bring on as much euphoria as complete agonist like H, OC, Hydrocodone, Morphine, etc. And taking it if you aren't an addict and trying to quit is a bad idea because it RAPIDLY increases your opiate tolerance.

You can get A LITTLE high off of buprenorphine even if you are an addict by taking 600mgs of St. Johns Wort before you take double your normal amount of Buprenorphine. This is debateable, but swim has personally tried it and swim felt a slight high. St. Johns Wort is an inducer of the CYP3A4 liver enzyme which is responsible for the breaking down of buprenorphine. You would think that would be a bad thing because it would "burn off" the Bupe quicker and IT DOES. But it metabolizes the Buprenorphine into NORbuprenorphine which is a FULL AGONIST which will increase the euphoria.

This can be dangerous because NorBuprenorphine is very strong and dangerous so I can't reccomend this to anyone, but if you do try this do it with caution and DON'T TRY IT IF YOU ARE OPIATE NAIVE!!!!!!


But I digress.... Buprenorphine is the opposite of toxic. It's not good to take if you aren't an addict because you can become an addict and it sky rockets your tolerance, however, if you are an addict it is a Godsend and by NO MEANS toxic. It has saved me from a dark depressing junky life that I was destined to lead the rest of my days...... But with the help of family, friends, the Lord, my addiction specialist, my therapist, AND BUPRENORPHINE I have been clean for over a year now. I started out at 32mgs a day of Bupe and worked my way down to 2mgs a day in a little over 6 months. It was VERY comfortable....I felt ZERO withdrawals until I quit taking it COMPLETELY after getting down to 2mgs a day and even then the withdrawals were EASILY manageable with anti-anxiety, anti-depressant, and sleeping medication...in addition to clonidine. I felt tired, weak, anxious, and depressed BUT I was able to sleep at least 4 hours a night which I could NEVER do withdrawing from OC. That lasted about a week and then I had another week or so where I still felt kinda crappy but it was ALOT better and then I was pretty much fine. I had since months to get out of "The Life" and get used to not being high and filling my day with productive things. It has taken a lot of prayer, therapy, and help from friends and family since then but it was well worth it.

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Very true; for heroin addicts buperenorphine is a miracle
  #12  
Old 31-05-2008, 18:40
kailey_elise kailey_elise is offline
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Re: Potentiating Buprenorphine

TPIK is looking to potentiate in order to make his script last longer, not to get high off of it.

Any thoughts? There's concern that the usual methods to potentiate opiates might backfire, and I'm having a really hard time finding any (semi-)definitive information for him. *sigh*

~Kailey_Elise
  #13  
Old 24-07-2008, 19:37
Talynt Talynt is offline
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Buprenorphine Potentiator Question

SWIM has recently used Buprenorphine and had some very good outcomes. Swim is wondering what would be a potentiator for Buprenorphine that isnt a or an Benzo or alcohol. What Swim looking for is more of an OTC potentiator. Response would be appreciated!

Talynt added 585 Minutes and 51 Seconds later...

*bump*

Last edited by Talynt; 24-07-2008 at 19:37. Reason: Automerged Doublepost
  #14  
Old 24-07-2008, 20:39
drug-bot drug-bot is offline
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Re: Buprenorphine Potentiator Question

swim knows benzo's are the best potentiator. but as far as otc, possibly a small amount of benedryal (s/p?), kava-kava would most likely be good as well.
remember be careful about mixing other cns depressors with an opiate (even if its only a partial-opiod ike buprenorphine), alittle can result in a pleasurable experience, too much could cause an overdose.

Last edited by drug-bot; 24-07-2008 at 20:40. Reason: spelling
  #15  
Old 24-07-2008, 23:12
Talynt Talynt is offline
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Re: Buprenorphine Potentiator Question

This is kind of off topic but SWIM says that the Bupe isnt effecting him like it did yesterday might be because SWIM took a gabapentin and 25mg of diph swim doesnt know any suggestions?
  #16  
Old 25-07-2008, 04:24
lexifer lexifer is offline
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Re: Buprenorphine Potentiator Question

Plenty of threads on this sort of thing. Use the search engine.

Here's a couple:

https://drugs-forum.com/forum/sho...e+potentiation

https://drugs-forum.com/forum/sho...e+potentiation


Most substances that work to potentiate heroin, morphine and other opiates work for pretty much all opiates, including buprenorphine. Those two posts are really all you're going to need in SWIM's opinion.

The search engine is SWIY's best friend on this forum.
  #17  
Old 30-07-2014, 03:35
mygreenbic mygreenbic is offline
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Re: Anyways of potentating suboxone?

Quote:
Originally Posted by jerbles View Post
Since suboxone is used sublingually I don't know think the grapefruit juice would work, because the sub isn't in your stomach (where the juice goes).
I'm not sure that is a correct answer. The gfj is a liver enzyme inhibitor which metabolizes the buprenorphine. I don't think I would want to produce extra buperenorphine though because the inhibiting prevents buprenorphine (partial agonist) from being converted to it's metabolite which is a full agonist)(basically meaning it's a regular opiate. The more bupe you take the less like a nodding opiate feeling. This is because the buprenorphine which is the parent ďrug of norbup blocks the nor from binding to the mu receptors because of its potent affinity for mu. This is why IMO smaller doses of subs are better. Some people like high dose sub though because it's more of an energetic type high where you are more talkative and outgoing. And by the way about the stomach thing, some of it is ingested into the stomach. When the bioavailability is figured out for let's say the suboxone strips, they take into account how much of it is swallowed and put the gi ba mix it with the sublingual ba. I'm sorry my dxm, gfj, xanax, klonopin, ambien mixture kicked in half way through this reply and i keep nodding like I'm on heroin every other word I type. I am on high dose of each drug two and as quickly as it is kicking my ass I don't think I'm going to make it anther ten minutes without passing out. I apologixe if this post isn't masking sense but I can't even screen the sre dvd m
  #18  
Old 24-09-2014, 23:49
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Re: Anyways of potentating suboxone?

Quote:
Originally Posted by jerbles View Post
Since suboxone is used sublingually I don't know think the grapefruit juice would work, because the sub isn't in your stomach (where the juice goes).
This person clearly does not comprehend that it doesn't matter which route of administration you use, it matters what effect the drug or compound has on your system (i.e. liver enzymes and breakdown of drugs) that causes the interactions we are concerned with in this case.
  #19  
Old 25-09-2014, 00:35
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Re: Potentiating Buprenorphine

^^the route of administrastion makes all the difference when sublingual.because it bypassess the liver. And most opiate potentiators rely on effecting the liver As someone pointed out some will be swallowed. But most is absorbed in the bloodstream. that's why the question was first asked.. suboxone is very different then other opiates. In its make up. And its route of administration.

To answer the question. Alcohol. Either gargle some before you put the suboxone under your tongue. Or dissolve it in a little and take that sublingually.
  #20  
Old 25-09-2014, 13:59
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Re: Potentiating Buprenorphine

I have used gabapentin with suboxone and it potentiates it very well if you take the gabapentin a couple of hours before the subs. The best thing though IMO is cannabis. Buprenorphine on its own doesnt give much of a buzz but a joint smoked after taking it makes it a much stronger effect.
  #21  
Old 27-09-2014, 17:05
LasVegasEd777 LasVegasEd777 is offline
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Re: Potentiating Buprenorphine

I am not sure about potentiation, but adding Valium makes me feel very comfortable.
  #22  
Old 06-10-2014, 05:59
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Re: Potentiating Buprenorphine

Quote:
Originally Posted by Cwb20022 View Post
^^the route of administrastion makes all the difference when sublingual.because it bypassess the liver. And most opiate potentiators rely on effecting the liver As someone pointed out some will be swallowed. But most is absorbed in the bloodstream. that's why the question was first asked.. suboxone is very different then other opiates. In its make up. And its route of administration.

To answer the question. Alcohol. Either gargle some before you put the suboxone under your tongue. Or dissolve it in a little and take that sublingually.
There is always plugging
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Old 29-10-2014, 16:00
7eeing7evens 7eeing7evens is offline
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Re: Potentiating Buprenorphine

Quote:
Originally Posted by Hardstepa View Post
I have used gabapentin with suboxone and it potentiates it very well if you take the gabapentin a couple of hours before the subs. The best thing though IMO is cannabis. Buprenorphine on its own doesnt give much of a buzz but a joint smoked after taking it makes it a much stronger effect.
Indeed, gabapentin combines very well
  #24  
Old 29-10-2014, 16:39
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Re: Potentiating Buprenorphine

Pgp inhibitors increase the duration for some opiates, haven't seen specific reference to bup, but it's not something I've looked for. I'm sure a Internet search of bup drug interactions would throw some light. If you can find which enzymes or metabolic paths effectively removes the drug, then find out what inhibits it.

Last edited by Dreggs; 29-10-2014 at 16:46.
  #25  
Old 18-11-2014, 04:01
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Re: Potentiating Buprenorphine

Quote:
Originally Posted by kailey_elise View Post
TPIK is looking to potentiate in order to make his script last longer, not to get high off of it.

Any thoughts? There's concern that the usual methods to potentiate opiates might backfire, and I'm having a really hard time finding any (semi-)definitive information for him. *sigh*

~Kailey_Elise
Just want to hate a bit

You are just doing it to make your script last... Come on that's rationalization 101. You want to get fucked up just be honest about it.... But maybe your lying to yourself I dono take a look at it

fishyd55 added 5 Minutes and 11 Seconds later...

Quote:
Originally Posted by mygreenbic View Post
I'm not sure that is a correct answer. The gfj is a liver enzyme inhibitor which metabolizes the buprenorphine. I don't think I would want to produce extra buperenorphine though because the inhibiting prevents buprenorphine (partial agonist) from being converted to it's metabolite which is a full agonist)(basically meaning it's a regular opiate. The more bupe you take the less like a nodding opiate feeling. This is because the buprenorphine which is the parent ďrug of norbup blocks the nor from binding to the mu receptors because of its potent affinity for mu. This is why IMO smaller doses of subs are better. Some people like high dose sub though because it's more of an energetic type high where you are more talkative and outgoing. And by the way about the stomach thing, some of it is ingested into the stomach. When the bioavailability is figured out for let's say the suboxone strips, they take into account how much of it is swallowed and put the gi ba mix it with the sublingual ba. I'm sorry my dxm, gfj, xanax, klonopin, ambien mixture kicked in half way through this reply and i keep nodding like I'm on heroin every other word I type. I am on high dose of each drug two and as quickly as it is kicking my ass I don't think I'm going to make it anther ten minutes without passing out. I apologixe if this post isn't masking sense but I can't even screen the sre dvd m
Fuck yea man that is some funny shit.. But yea they whole grapefruit thing isn't a stomach acid thing. It is an actual chemical reaction that occurs in the brain. I don't kno much about it but I used to be a dex- head, and once I combined dam with a bunch of grapefruit juice and my trip was completely different I felt more like a tryptamine than a diss associative. Just saying grapefruit can do some wonderful things I am going to do more research in this are

Post Quality Evaluations:
Maybe take a look at the dates posts were made and how the person has come on since then before hating and coming across the way you do.

Last edited by fishyd55; 18-11-2014 at 04:01. Reason: Automerged Doublepost

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