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25C-NBOMe (NBOMe-2C-C) is a novel psychedelic research chemical and derivative of the phenethylamine 2C-C. It is significantly more potent that 2C-C with an active dose in the mid-microgram range and can cause very intense experiences, some users describe it as very similar to LSD. It is typically dissolved in water and insufflated. It has been reported to have less 'after effects' and generally less unwanted side effects than traditional compounds from the 2C-X series.


[top]Introduction to 25C-NBOMe


A new range of psychedelics have started to enter the research chemical scene. Researchers headed by David E. Nichols at Purdue are making new versions of old psychedelics (mainly those first synthesized by Alexander Shulgin) as well as other novel psychedelic compounds.

25C-NBOMe is derived from the psychedelic phenethylamine 2C-C (4-chloro-2,5-dimethoxylphenethylamine) by substitution on the amine with a 2-methoxybenzyl (BOMe) group.

This addition to the molecule makes it much, much more potent and more psychedelic than 2C-C, with a strong dose being 1mg+ compared to 40mg+ for 2C-C

The drug is a very potent partial agonist of the 5HT-2A receptor (which belongs to the serotonin group of receptors) giving it its psychedelic effects. It is around 5 x the potency of LSD when insufflated, but reportedly displays relatively weak activity when dosed orally.

[top]Ways of Administration


(dissolved in water):
Light - 50-200 g (0.05 - 0.2 mg)
Mild - 200-350 g (0.2 - 0.35 mg)
Strong - 350-700 g (0.35 - 0.7 mg)
Very strong - 700 g -1200 g (0.7 - 1.2mg)
Insanity - 1200 g+ (1.2 mg+)
Fatal dose - Unknown but several have died from 25C-NBOMe

Never snort 25C-NBOMe pure, as the dose is too small. Always use a proper milligram scale.




Threshold - 100-250ug
Mild- 250-450ug
Strong - 450-800
Very strong - 800ug+
Fatal dose - Unknown but several have died from 25C-NBOMe

Always use a proper milligram scale.

Come Up 1hour+
Plateau 3-4hours

(More information needed to verify dosage)

[top]Effects of 25C-NBOMe

From liquid insuflation (strong dose):

Extreme patterning
Masses of vibrant colouring
Strong sound distortion - sounds leaking in and out of rooms and into the user
Very strong electric spasmodic body high

Complete ego loss
Loss of self
Loss of location, being, time, space etc

Inability to function at all normally
Slight nausea but passes quickly

The kitchen started to swirl around, everything became very colourful, but it the intensity increased exponentially. It became way way more intense than I had expected very very quickly. Panic started to take hold and no matter what I did I could not shake it off. I tried to reassure myself and tried to calm down but as my world started to become more and more chaotic and as I started to completely lose myself I found this impossible to do............
........Then things started to get really really nasty. The thoughts in which the loop seemed to be wrecking peoples' lives were interlaced with the thoughts that somehow I was doing something so terrible, so humiliating and disgusting that the whole world thought I was a joke and that I didn't deserve to live. I was completely dissociated and out of the room, I was on the ground outside being pelted with rubbish by hundreds of people. There were ambulances, police cars and my dad all whirling round. This image remained for a long time. However after a while it was as if people understood and whilst some still hated me others were rooting me on to make it through to the other side of this trip. - Psychedelaholic 2011

[top]Combinations with 25C-NBOMe

From liquid insuflation (weaker dose 350ug):

[top]Different Uses for 25C-NBOMe

[top]Pharmacology of 25C-NBOMe

[top]Chemistry of 25C-NBOMe

IUPAC: 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
Formula: C18H22ClNO3
R.m.m 355.824 g/mol

The 2-methoxybenzyl group attached at a nitrogen usually serves as a protecting group so that the functionality of the amine group is retains during a reaction. However here, for the 2C-C version and other 2C-Xs is massively increases potency. However this is not the case for all drugs of this nature.

The following image displays the structural relationship between 2C-C, 2-methoxytoluene, and 25C-NBOMe.

[top]The Dangers of 25C-NBOMe

It is incredibly potent when taken intranasally or injected. The effects come on very fast and could easily overpower even well experienced users. The potency also makes it hard to dose correctly without powerful scales which a lot of recreational users do not have or have access too.

These are the dangers common to all psychedelic drugs:

Accidental injury.
When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.

Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.

Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.

PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.

[top]25C-NBOMe deaths

25C-NBOMe has lead to several fatalities.

[top]Producing 25C-NBOMe

[top]Forms of 25C-NBOMe

Powder (both in a pure form, and in single doses mixed with carrier powder)
tabs - Usually 300-350ug
liquid in LSD style dropped bottles

[top]Legal Status of 25C-NBOMe

[top]United Nations



Uncontrolled at Federal and State level, though arguably may contravene the Federal Analog Act under certain circumstances given its structural and functional similarity to controlled substance 2C-B.



[top]United Kingdom

25C-NBOMe is uncontrolled in the United Kingdom, as N-benzyl derivatives of phenethylamine are not covered by the phenethylamine derivatives clause of the Misuse of Drugs Act 1971.

[top]Other Countries

[top]History of 25C-NBOMe

It was invented by David E. Nichols (born on 23/12/44) with his team at Purdue University

[top]Street Names/Synonyms for 25C-NBOMe


[top]More 25C-NBOMe Sections

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Created by psychedelaholic, 21-05-2011 at 10:08
Last edited by Beenthere2Hippie, 26-01-2014 at 02:58
Last comment by uncle_bud on 02-01-2014 at 18:52
19 Comments, 168,373 Views

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