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2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a psychedelic phenethylamine first described by chemist Alexander Shulgin in his book PiHKAL: A Chemical Love Story. 2C-B is usually taken orally or insufflated with a typical dose in the range of 5-20mg. 2C-B has both hallucinogenic and entactogenic properties, and is often described as being more euphoric than other phenethylamines. Shulgin even commented in the entry for 2C-B in PiHKAL, that it had aphrodisiac qualities and was used in psychotherapy as a replacement for MDMA soon after it became scheduled by the DEA, but it soon gained popularity in the "Rave Culture" as the next MDMA (also known as Nexus), and was also scheduled under the CSA.


[top]Introduction to 2C-B

[top]Using 2C-B

[top]Ways of administration

The most common method of administration is oral. 2C-B can be used through sublingual administration but has a very reportedly chemical taste. Many users prefer to insufflate their dose for a quicker hitting high but this is said to a rather painful method that will induce a strong burning sensation.

[top]Effects of 2C-B

[top]Combinations with 2C-B

Combining 2C-B with MDMA is said to greatly enhance the effects of MDMA, increasing the users euphoria, hallucinations, light trails, body rushes and energy as well as increasing the longevity of MDMA. The combination is also said to lower the intensity of the users MDMA 'crash'. Users who have experienced nervousness, jitters, insomnia and depression after the effects of MDMA wear off have experienced a great reduction in all or some of the 'crash' symptoms and have even reported being able to sleep after using the combination whereas with MDMA alone they would be unable to sleep for 12 to 24 hours after the effects wear off.

[top]Different Uses for 2C-B

Before it was scheduled, 2C-B was sold in small doses as an aphrodisiac Some users report aphrodisiac effects at lower doses (5–10 mg) but consider the hallucinations a “turn-off” or distracting at higher dosages (greater than 15 mg).

2C-B is used as entheogen by the Sangoma, Nyanga, and Amagqirha people over their traditional plants; they refer to the chemical as Ubulawu Nomathotholo, which roughly translates to "Medicine of the Singing Ancestors".

[top]Pharmacology of 2C-B

[top]Chemistry of 2C-B

Systematic (IUPAC) name:4-bromo-2,5-dimethoxybenzeneethanamine
Synonyms:4-bromo-2,5-dimethoxyphenetylamine, α-desmethyl DOB, BDMPEA, MFT, nexus
Molecular Formula:C10H14BrNO2, C10H14BrNO2.HCl (hydrochloride)
Molar mass:260.13 g/mol, 293.59 g/mol (hydrochloride) [2]
CAS Registry Number:66142-81-2, 56281-37-9 (hydrochloride)
Melting Point:237-239°C (hydrochloride) (with decomposition)[1][3]
Boiling Point:no data
Flash Point:no data
Solubility:Freebase: soluble in ether, chloroform, methanol; insoluble in water[3]. Hydrochloride: soluble in chloroform, methanol, water; slightly soluble in acetone; insoluble in ether[3].
Additionnal data:none
Notes:Hydrochloride aspect pale pink crystals; crystallized from ethanol[1]

[top]Reagent test results of 2-CB

Reagent color produced picture video
H2SO4 No reaction, fizzes[1] link -
Marquis Yellow to green to dark green[3][1] - -
Mecke green to yellow (slow) to blue (slow)[3] - -

[top]The dangers of 2C-B

These are the dangers common to all psychedelic drugs:

Accidental injury.
When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.

Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.

Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.

PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.

[top]Producing/Growing 2C-B

[top]Forms of 2C-B

2C-B is a controlled substance 21 CFR 1308.11

[top]Legal status of 2C-B

[top]United Nations


2C-B is a Schedule I controlled substance at Federal level under the Controlled Substances Act.


[top]United Kingdom

2C-B is a class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act 1971.

[top]Other Countries

[top]History of 2C-B

[top]Popularity of 2C-B over time

Popularity over time:

[top]More 2C-B Sections

[top]The latest 2C-B threads

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[1] Merck Index, fifteenth edition (2013)
[2] Calculated from Atomic Weights of the Elements, 2007
[3] 2-CB monograph
  1. ^ a b http://www.reagent-base.net/reagents-table/

Created by BA, 17-12-2010 at 16:41
Last edited by John_bob, 13-06-2015 at 21:57
Last comment by PharmaCycle on 19-12-2012 at 18:25
6 Comments, 42,974 Views

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