acts as a strong dissociative drug
in a similar fashion to that of phencyclidine (PCP). While the effects of the two compounds may be similar, they are not identical, as 3-MeO-PCP has a binding profile for the target receptors which is slightly altered to that of phencyclidine (PCP). The psychoactive
effects of 3-MeO-PCP are derived primarily through its ability to antagonise the NMDA receptors as well as inhibit the reuptake of dopamine
. Compared to phencyclidine (PCP), 3-MeO-PCP is a considerably more potent NMDA agonist, while its ability to inhibit the reuptake of dopamine is equivalent to that of phencyclidine (PCP). 3-MeO-PCP has Ki values of 20 nM for NMDA, 216 nM for serotonin
, and 42 nM for sigma 1.