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5F-AKB48 has a strong binding affinity for the peripheral CB2 cannabinoid receptors, while possessing a greatly reduce affinity for the central CB1 cannabinoid receptors. While its molecular structure differs only slightly from that of AKB48 by the addition of fluorine at the terminal carbon of the pentyl chain, the effects are reported to be significantly more potent than that of the parent compound.
Like the majority of the other cannabinoids, 5F-AKB48 can be vaporized in its pure powder form or laced onto a dried plant material and smoked out of a pipe, additionally 5F-AKB48 can be consumed orally with the assistance of a carrier that is high in fat content. Examples of a carrier would be whole milk, cream, butter, peanut butter, and olive oil.
As with everything, inhaling the combustion of any material is harmful to the lungs, esophagus, mouth, and sinus cavities. With 5F-AKB48 the risk is significantly greater due to the fact that the compound is still considered a research chemical and lacks any sort of formal trials. Likewise 5F-AKB48 may further exaggerate any pre existing mental or physical health conditions and should be avoided if this is the case.