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5F-PB-22 is a synthetic cannabinoid and full agonist of the CB1/CB2 cannabinoid receptors as well as the fluorinated analog of PB-22 (a novel cannabinoid receptor agonist).


[top]Introduction to 5F-PB-22

5F-PB-22 is a derivative of PB-22, having a fluorine atom at the terminal carbon of the pentyl chain, 5F-PB-22 acts as a full agonist for both the CB1 and CB2 cannabinoid receptors, with a significantly higher binding affinity for the CB2 receptor over the CB1 receptor. 5F-PB-22 is a novel cannabinoid, first appearing on the market in late the 2012 to early 2013 time frame. There is limited information on the pharmacological and toxicological properties of this compound.

[top]Using 5F-PB-22

[top]Ways of Administration

The most common route of administration for 5F-PB-22 is by vaporizing and inhaling the byproduct of its combustion thus absorbing the compound through the lungs. 5F-PB-22 is also laced onto a dried plant material and smoked out of a pipe. Alternatively 5F-PB-22 can be consumed orally as with many other cannabinoid, by the addition of a carrier which is high in fat content. Examples of a carrier are whole milk, cream, butter, peanut butter, and olive oil.

[top]Effects of 5F-PB-22


  • Euphoria
  • Relaxation
  • Feelings of joy and laughter


  • Hunger
  • Lethargy
  • Mild visual distortions


  • Anxiety
  • Paranoia
  • Delusions
  • Irrational thought process

[top]Chemistry of 5F-PB-22

Systematic (IUPAC) name:1-​(5-​fluoropentyl)-​8-​quinolinyl ester-​1H-​indole-​3-​carboxylic acid
Molecular Formula:C23H21FN2O2
Molar mass:376.42 g/mol [1]
CAS Registry Number:1400742-41-7
Melting Point: 
Boiling Point: 
Flash Point:no data
Additionnal data: 

NMR FTIR and GC/MS analyses can be found here

[top]The Dangers of 5F-PB-22

It is well know that inhaling the byproduct of combustion is harmful no matter what the object may be. The danger however is significantly increased with 5F-PB-22 due to the fact that it is a research chemical and has yet to undergo any sort of formal studies. Like wise the consumption of any drug by a person whom is either mentally unfit or has a family history of mental illness is dangerous as the drug may potentiate the onset of some sort of psychotic behavior.

[top]Legal Status of 5F-PB-22

[top]United Nations



[top]Other Countries


[1] Calculated from Atomic Weights of the Elements, 2007

Contributors: John_bob, syntheticdave
Created by syntheticdave, 04-07-2013 at 23:24
Last edited by John_bob, 14-07-2014 at 17:38
Last comment by syntheticdave on 06-07-2013 at 20:18
1 Comments, 3,457 Views

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