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Amitriptyline (Elavil, Endep, Saroten, Sarotex, Redomex, Adepril, Amineurin, Domical, Euplit, Laroxyl, Lentizol, Miketorin, Triptizol, Tryptanol, Tryptizol) is one of the most frequently used tricyclic antidepressants. Its effects are mediated notably by increasing serotonin and norepinephrine concentrations in the brain. However, other modes of action are likely to contribute to its antidepressant effects as well. This pharmacological profile is also why, beyond its use for treating mood disorders, it can be beneficial for the treatment of certain types of pain. It has practically no value as a recreational drug.


[top]Introduction to Amitriptyline

[top]Using Amitriptyline

[top]Ways of Administration

[top]Swallowing Amitriptyline

Oral use is the most common form of administration for Amitryptyline, and it is normally provided in 10mg, 25mg, or 50mg pills. Other routes of administration would appear to be pointless, as it has no recreational value.

[top]Snorting Amitriptyline

[top]Injecting Amitriptyline

[top]Plugging Amitriptyline

[top]Effects of Amitriptyline

[top]Combinations with Amitriptyline

[top]Different Uses for Amitriptyline

Amitryptyline is sometimes prescribed for sleep disorders in the UK when other drugs have been found to be ineffective.

[top]Pharmacology of Amitriptyline

Amitriptyline is a Serotonin-Norepinephrine reuptake inhibitor. It also is a negative allosteric modulator at the PCP site of the NMDA receptor.

LD50 (mg/kg) :
Mice : 350 orally, 65 intraperitoneal
Rat : 380 orally, 75 intraperitoneal

[top]Chemistry of Amitriptyline

Systematic(IUPAC) name:3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine
Synonyms: 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]cycloheptadiene, 10,11-dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-[Delta]^5,[gamma]-propylamine, 5-([gamma]-dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene, 10,11-dihydro-5-([gamma]-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene ; Elavil, Endep, Saroten, Sarotex, Redomex, Adepril, Amineurin, Domical, Euplit, Laroxyl, Lentizol, Miketorin, Triptizol, Tryptanol, Tryptizol (hydrochloride)
Molecular Formula:C20H23N
Molar mass:277.403 g/mol; 313.87 g/mol (hydrochloride)
CAS Registry Number:50-48-6; 549-18-8 (hydrochloride)
Melting Point:196-197℃ (hydrochloride)
Boiling Point: no data
Flash Point: no data
Solubility: Freely soluble in water, chloroform, alcohol (ethanol). Insoluble in ether.
Additionnal data: pKa 9.4

[top]The Dangers of Amitriptyline

[top]Producing Amitriptyline

[top]Forms of Amitriptyline

[top]Legal Status of Amitriptyline

[top]United Nations


Available only by prescription, known as Endep.



Available only by prescription.


Amitriptyline (Elavil) is unscheduled in the United States. Available only by prescription. This means that sales and distribution are allowed only by those with a license and only to those with a prescription (according to FDA regulations). Possession of Amitriptyline is not illegal without prescription.

[top]History of Amitriptyline

[top]Popularity of Amitriptyline over time

[top]More Amitriptyline Sections

[top]The Latest Amitriptyline Threads

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Created by Ilsa , 02-03-2012 at 00:55
Last edited by John_bob, 19-04-2014 at 12:34
Last comment by John_bob on 19-04-2014 at 12:37
8 Comments, 18,974 Views

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amitryptaline, snri adverse effects, snri side effects, snri withdrawal, tricyclic antidepressants
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