Hypersensitivity, severe respiratory and liver disease, closed angle-glaucoma, pregnancy and lactation.
In post marketing studies up to 50% of people experienced transient adverse effects, which were more likely at higher doses. Very common (greater than 25%) were somnolence, confusion and ataxia
. Common (up to 25%) were headache, depression, slurred speech, poor concentration, changes in libido, GI upset and hypersalivation. Uncommon (1-9%): Jaundice, dermatitis/urticaria, low blood counts, psychosis and paradoxical excitation. Rarely (less than 1%): Hypo/Hypertension
, bradycardian and tachycardia
As with all benzodiazepines a physical tolerance develops with as little as 14 days of continuous use. Brotizolam should not be discontinued suddenly.