Drugs-Forum  
Home Wiki Studies Forum Groups Blog Video Images News Chat
Go Back   Drugs Forum > Wiki Articles > Drug Articles
Mark Forums Read
Register Tags

Notices

Drug Articles Articles about drugs

Clonidine

Clonidine is a drug that acts as an alpha-2 adrenergic agonist, the main effect being lowering blood pressure because it decreases the release of norepinephine and epinephrine (adrenalin). It is prescribed for people with high blood pressure, as well as being the main pharmacological remedy for opioid withdrawal due to its effects on the central nervous system. It helps alleviate some of the physical withdrawal symptoms such as excessive sweating and hot/cold flashes.

Contents




[top]Introduction to Clonidine



[top]Using Clonidine

Clonidine can be taken orally as prescribed for high blood pressure. Its use has also been reported in shaving soaps.

[top]Ways of Administration

[top]Taking Clonidine Orally

[top]Snorting Clonidine

[top]Injecting Clonidine

[top]Plugging Clonidine

[top]Effects of Clonidine

Clonidine lowers blood pressure and eases symptoms of opioid withdrawal such as hot/cold flashes and excessive sweating. Clonidine can make the user drowsy or sleepy, and these effects are more prominent if clonidine is injected. Clonidine can have some anxiolytic (anxiety reducing) effects as well by relaxing the body.

[top]Combinations with Clonidine

[top]Different Uses for Clonidine



[top]Pharmacology of Clonidine

Clonidine is an alpha-2 adrenergic agonist. Activation of these receptors decreases release of norepinephrine and epinephrine. Clonidine lowers blood pressure.

LD50 (mg/kg) (as the hydrochloride) [1] :
Mice : 328 orally, 18 intravenously
Rat : 270 orally, 29 intravenously


[top]Chemistry of Clonidine


Systematic (IUPAC) name:N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Synonyms:2-(2,6-dichloroanilino)-2-imidazoline, 2,6-dichloro-N-2-imidazolidinylidenebenzenamine, 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2), 2-[(2,6-dichlorophenyl)-imino]-2-imidazoline; ST-155, Catapres, Catapressan, Clonistada, Dixarit, Duraclon, Isoglaucon, Paracefan (hydrochloride)
Molecular Formula:C9H9Cl2N3, C9H9Cl2N3.HCl
Molar mass:230.09 g/mol, 266.55 g/mol (hydrochloride)
CAS Registry Number:4205-90-7, 4205-91-8 (hydrochloride)
Melting Point:130C, 305C (hydrochloride)
Boiling Point:no data
Flash Point:no data
Solubility:Freebase freely soluble in methanol, alcohol; Hydrochloride 1 g dissolves in 6 mL water (60C), about 13 mL water (20C), about 5.8 mL methanol, about 25 mL ethanol, about 5000 mL chloroform; soluble in absolute ethanol; slightly soluble in chloroform; practically insoluble in ether
Additionnal data:none
Notes:Freebase aspect : white to almost white crystals
[1]


[top]The Dangers of Clonidine

[top]Danger 1

[top]Danger 2

[top]Danger 3

[top]Danger 4



[top]Producing Clonidine



[top]Forms of Clonidine

[top]Tabs



[top]Legal Status of Clonidine

[top]United Nations

[top]USA

[top]EU

[top]Other Countries



[top]History of Clonidine

[top]Popularity of Clonidine over time




[top]The Latest Clonidine Threads


  Article / Page Starter Last Post Comments Views
Hideyourlies
26-09-2016 15:23
by aemetha Go to last post
1 76
ecodesmoker
25-09-2016 19:11
by ianzombie Go to last post
1 64
Vicmon123
22-09-2016 22:40
by Vicmon123 Go to last post
8 1,377
inkfrommypen
22-09-2016 02:19
by inkfrommypen Go to last post
0 84
Mr.Garland
18-09-2016 04:35
by Mr.Garland Go to last post
0 134
KennyPowersVIP
12-09-2016 06:54
by KennyPowersVIP Go to last post
5 313
Doodoo
06-09-2016 06:51
by Doodoo Go to last post
0 101
awowogei
02-09-2016 19:33
by awowogei Go to last post
0 202
afriendoftina
29-08-2016 22:50
by afriendoftina Go to last post
0 224
Xtal
23-08-2016 13:27
by Xtal Go to last post
0 325


[top]References


[1]Merck Index, fifteenth edition (2013)


Contributors: John_bob, Alfa, Docta, NeuroChi
Created by NeuroChi, 12-04-2012 at 02:48
Last edited by John_bob, 09-05-2014 at 14:07
0 Comments, 34,583 Views

Share this on:

Tags
clonidine, opioid withdrawal
Page Tools


Posting Rules
You may not create new articles
You may not edit articles
You may not protect articles

You may not post comments
You may not post attachments
You may not edit your comments

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Sitelinks: Information:

All times are GMT +1. The time now is 01:04.


Copyright: SIN Foundation 2003 - 2014, All rights reserved