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►►Welcome to the Drugs-Forum wiki. The following articles are currently being written or expanded on by the members of this forum. The information found within the collection of articles hosted below may vary from day to day as the devoted team of wiki crew members in addition to the various members of this forum are constantly correcting, creating, formatting, and revising the content found within each and every wiki in order to provide the reader with the most accurate information available. If you have any sort of knowledge on a specific topic or drug, or you have the desire to research a specific topic or drug, than please feel free to contribute to our ever growing wiki. For more information on how you can contribute to the wiki, please visit the "Contributing to the Wiki" section by clicking on the hyperlink, or scrolling to the bottom of this page.


[top]Psychoactive Substances & Plants


►►Antidepressant is an umbrella term used to describe a wide range of pharmaceutical drugs that share the fact that they are used in the treatment of major depressive disorder. Antidepressants come in a variety of different forms, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). The primary effect of an antidepressant drug is of course the compounds ability to treat depression, however many antidepressants are also used to treat other psychiatric conditions such as anxiety or obsessive-compulsive disorder (OCD). Furthermore, some of these agents can also be used "off-label" to help with other conditions, such as nerve pain, dysmenorrhea, and a plethora of other disorders and conditions.

ArticleImageAlternative name(s)Chemical class(es)
AmitriptylineAdepril, Amineurin, Domical, Elavil, Endep, Euplit, Laroxyl, Lentizol, Miketorin, Redomex, Saroten, Sarotex, Triptizol, Tryptanol, TryptizolTricyclic Antidepressant
BupropionAmphebutamone, Aplenzin, Budeprion, Wellbutrin, ZybanAmphetamines, Beta-Ketones, Cathinones, NDRI, Phenethylamines
CitalopramCelexa, Cipramil, Elopram, Nitalapram, SeropramSSRI
ClomipramineAnafranil, Clomicalm, ChlorimipramineTricyclic Antidepressant
DesipramineDesmethylimipramine, Norimipramine, Nortimil, Norpramin, Pertofran, Pertofrane, PetylylTricyclic Antidepressant
Desvenlafaxine PristiqPartial SSRI, Partial SNRI
Dexmethylphenidated-threo-methylphenidate, D-TMP, FocalinNDRI
Duloxetine Ariclaim, Cymbalta, YentrevePartial SSRI, Partial SNRI
EscitalopramCipralex, Gaudium, LexaproSSRI
FluoxetineAdofen, Fluctin, Fluneurin, Fluoxeren, Fluox-Puren, Flusol, Fluxet, Fontex, Foxetin, Lovan, Prozac, Reconcile, SarafemSSRI
Fluvoxamine Dumirox, Faverin, Fevarin, Floxyfral, Luvox, MaveralSSRI
ImipramineChrytemin, Imidol, Imizin, Melipramine, Pryleugan, Tofranil, Tofranil-PM Tricyclic Antidepressant
MirtazapineMepirzepine, Remeron, Zispin, Zispin SoltabTetracyclic Antidepressant, NaSSA
Paroxetine Aropax, Deroxat, Divarius, Euplix, ParoLich, Paroxat, Paxil, Pexeva, Sereupin, Seroxat, TagonisSSRI
Reboxetine Davedax, Edronax, Norebox, Prolift, Solvex, VestraAntidepressants NaRI
SelegilineAmindan, Anipryl, Antiparkin, Carbex, Deprenyl, Egibren, Eldepryl, Emsam, Jumex, Movergan, Otrasel, Plurimen, Seledat, Selegam, Selepark, Selgimed, Xilopar, ZelaparAmphetamines, MAOI, Phenethylamines
Sertraline Lustral, ZoloftSSRI
Trazodone Desyrel, Molipaxin, Oleptro, Thombran, Trazolan, TritticoAntidepressants
VenlafaxineEffexorPartial SSRI, Partial SNRI


►►Benzodiazepines are a class of chemicals sharing a set of common benzene and diazepine rings as core structures. They came into use in the 1960s to replace barbiturates, having been shown to be marginally safer, and thought to pose lower risk of addiction and dependency, though this has been brought into question recently. Benzodiazepines are most commonly prescribed to treat anxiety, muscle spasms, insomnia, or seizures because of their anxiolytic, hypnotic and anti-convulsive properties. While benzodiazepines act via similar mechanisms, they differ pharmacologically, each having its own time to onset, length of action, set of effects and therapeutic suitability for specific conditions or problems.

ArticleImageAlternative name(s)Chemical class(es)
AlprazolamAlplax, Cassadan, Esparon, Mylan A1, Tafil, Tranquinal, Trankimazine, Xanax, ZopaxBenzodiazepines
BromazepamBromaze, Compendium, Creosedin, Durazanil, Lectopam, Lexomil, Lexotan, Lexotanil, NormocBenzodiazepines
Brotizolam Lendorm, Lendormin, Mederantil, Nimbisan, SintonalBenzodiazepines
ChlordiazepoxideLibrium, LibritabsBenzodiazepines
ClonazepamKlonopin, Paxam, Rivotril, ValpaxBenzodiazepines
DiazepamAntenex, ValiumBenzodiazepines
Estazolam SomnatrolBenzodiazepines
EtizolamDepas, Etilaam, Etizola, SedekopanBenzodiazepine Analogs, Thienzodiazepines
FlunitrazepamRohypnol, RoofiesBenzodiazepines
MidazolamDormicum, VersedBenzodiazepines
NitrazepamAlodorm, MogadonBenzodiazepines
PhenazepamBonsai, SupersleepBenzodiazepines
TemazepamRestoril, Temaze, TemtabsBenzodiazepines
Triazolam Halcion, Songar, TrilamBenzodiazepines


►►Cannabinoids are a diverse class of both psychoactive and non-psychoactive chemical compounds that activate the CB1 and or CB2 cannabinoid receptors on cells that repress neurotransmitter release in the brain. These receptor proteins include the endocannabinoids AEA and 2-AG (produced naturally in the body by humans and animals), the phytocannabinoids THC and CBD (found in cannabis and some other plants), and synthetic cannabinoids JWH-018 and AM-2201 (produced chemically by humans). The most notable cannabinoid is the phytocannabinoid ∆9-tetrahydrocannabinol (THC), the primary psychoactive compound of cannabis. Cannabidiol (CBD) is another major constituent of the plant, representing up to 40% in its extracts. There are at least 85 different cannabinoids isolated from cannabis, exhibiting varied effects.

ArticleImageAlternative name(s)Chemical class(es)
5F-PB-221-(5-fluoropentyl)-1H-indole-3-carboxylic acid 8-quinolinyl esterCannabinoids
5F-UR-144(1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone, XLR-11Cannabinoids
AB-PINACAN-[(1S)-1-( aminocarbonyl)-2-methylpropyl]-1-pentyl-1H-indazole-3-carboxamideCannabinoids
AKB48APINACA, 1-pentyl-N-tricyclo[,7]dec-1-yl-1H-indazole-3-carboxamideCannabinoids
AM-22011-[(5-fluoropentyl)-1H-indol-3-yl]-(naphthalen-1-yl)methanoneNaphthoylindoles, Cannabinoids
BAY 38-7271(-)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluorobutyl-1-sulfonateCannabinoids
BB-22Quinolin-8-yl 1-(cyclohexylmethyl)-1H-indole-3-carboxylateCannabinoids
CannabisCannabis spp. sativa, indicaTetrahydrocannabinols, Cannabinoids
cannabidiol CBDcannabinoids
cannabinol CBNcannabinoids
CP-47,4972-[(1R,3S)-3-hydroxycyclohexyl]- 5-(2-methyloctan-2-yl)phenolCyclohexylphenols, Cannabinoids
CP-55,244 Cannabinoids
CP-55,9402-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-5-(2-methyloctan-2-yl)phenolCannabinoids
HashishCannabis resinTetrahydrocannabinols, Cannabinoids
Hashish OilHash Oil, Butane Honey Oil, Honey Hash Oil, BHOTetrahydrocannabinols, Cannabinoids
HU-210 Cannabinoids
JWH-0071-pentyl-2-methyl-3-(1-naphthoyl)indoleNaphthoylindoles, Cannabinoids
JWH-0181-pentyl-3-(1-nahpthoyl)indoleNaphthoylindoles, Cannabinoids
JWH-0191-hexyl-3-(naphthalen-1-oyl)indoleNaphthoylindoles, Cannabinoids
JWH-0221-​naphthalenyl[1-​(4-​penten-​1-​yl)-​1H-​indol-​3-​yl]-​methanoneNaphthoylindoles, Cannabinoids
JWH-030naphthalen-1-yl-(1-pentylpyrrol- 3-yl)methanoneNaphthoylindoles, Cannabinoids
JWH-073naphthalen-1-yl-(1-butylindol-3-yl)methanoneNaphthoylindoles, Cannabinoids
JWH-0814-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanoneNaphthoylindoles, Cannabinoids
JWH-122(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanoneNaphthoylindoles, Cannabinoids
JWH-147(1-hexyl-5-phenyl-1H-pyrrol-3-yl)-1-naphthalenyl-methanoneNaphthoylpyrroles, Cannabinoids
JWH-182(1-​pentyl-​1H-​indol-​3-​yl)(4-​propyl-​1-​naphthalenyl)-​methanoneNaphthoylindoles, Cannabinoids
JWH-200(1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanoneNaphthoylindoles, Cannabinoids
JWH-2032-(2-chlorophenyl)-1-(1-pentylindol-3-yl)ethanonePhenylacetylindoles, Cannabinoids
JWH-2104-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanoneNaphthoylindoles, Cannabinoids
JWH-2502-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanonePhenylacetylindoles, Cannabinoids
JWH-2512-(2-methylphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanonePhenylacetylindoles, Cannabinoids
JWH-307(5-(2-fluorophenyl)-1-pentylpyrrol-3-yl)-naphthalen-1-ylmethanoneNaphthoylpyrroles, Cannabinoids
JWH-370[5-​(2-​methylphenyl)-​1-​pentyl-​1H-​pyrrol-​3-​yl]-​1-​naphthalenyl-​methanoneNaphthoylpyrroles, Cannabinoids
JWH-3981-pentyl-3-(4-chloro-1-naphthoyl)indoleNaphthoylindoles, Cannabinoids
MAM-2201(1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone3-alpha-napthoylindole, Cannabinoids
Medical marijuana Cannabis spp. sativa, indicaCannabinoids
PB-221-​pentyl-​8-​quinolinyl ester-​1H-​indole-​3-​carboxylic acidCannabinoids
SpiceHerbal Incense, K2Cannabinoids
tetrahydrocannabinol THCcannabinoids
URB-597[3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamateCannabinoids
WIN-55,212-2 Cannabinoids


►►Deliriants are a category of hallucinogens with a typical mechanism of action occurring at the acetylcholine and histamine receptor sites in an antagonist type fashion. Sometimes referred to as true hallucinogens, deliriants are known to evoke hallucinations in the proper connotation of the word, where users may be seen having conversations with beings that do not exist in reality, talking to themselves in the mirror while at the same time being completely unaware of their own reflection, or displaying extreme states of confusion, agitation, and/or forgetfulness. As a result of these effects, deliriants tend to carry a greater danger potential than other hallucinogens, additionally many of the tropane alkaloids found in the plants listed below, which are considered to be deliriant drugs, are also toxic and can cause death at high doses, which is typically uncommon with many psychedelics and dissociatives.

ArticleImageAlternative name(s)Chemical class(es)
Atropine(RS)-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoateTropane Alkaloids
Diphenhydramine2-(diphenylmethoxy)-N,N-dimethylethanamineAntihistamine, Anticholinergic Agent
Bella DonnaAtropa belladonnaTropane Alkaloids
BrugmansiaBrugmansia spp.Tropane Alkaloids
DaturaDatura spp.Tropane Alkaloids
HyoscyamusHyoscyamus nigerTropane Alkaloids
MandrakeMandragora officinarumTropane Alkaloids


►►Depressants consist of a wide spectrum of both psychoactive and non-psychoactive substances which are classified only by the effect in which they have on the central nervous system (CNS). Typical depressants tend to possess sedative, anxiolytic, and/or hypnotic type effects. It is not uncommon for this class of drugs to cause respiratory depression, especially when combined with alcohol or other central nervous depressants. Likewise depressants can become dependence forming and result in withdrawal phenomenon if use is stopped abruptly.

ArticleImageAlternative name(s)Chemical class(es)
1,4-ButanediolTetramethylene glycol, BDOAlcohol
2-Methyl-2-Butanoltert-Amyl alcohol, 2M2BAlcohol
Absinthe Alcohol
AlcoholEthanol, Ethyl alcohol, EtOHAlcohol
Chloral HydrateSomnote, Escre, Noctec, Nycton, ChloralduratGeminol diol
Chlorobutanol1,1,1-Trichloro-2-methylpropan-2-ol, chlorbutol, Chloretone, Coliquifilm, Methaform, SedaformGeminol diol
GHBgamma-hydroxybutyric acid, sodium oxybate, Somsanit, Gamma-OH, XyremHydroxybutyrates
Phenprobamate3-Phenylpropylcarbamate, proformiphen, Extacol, Spantol, GamaquilCarbamate
ZaleplonAndante, Sonata, StarnocNonbenzodiazepine, Z-drug
ZolpidemAmbien, Intermezzo, Ivadal, Myslee, Niotal, Stilnoct, Stilnox, TovaltNonbenzodiazepine, Z-drug
ZopicloneAmoban, Imovane, Limovan, Sopivan, Ximovan, Zimovane, Rhovane, Zopiclona, Zopiclonum, Eszopiclone, Estorra, LunestaNonbenzodiazepine, Z-drug


►►Dissociative drugs are a category of hallucinogens which cause sensory deprivation by reducing the transmission of neurons within specific portions of the brain. Most typical dissociatives such as DXM, ketamine, and PCP are considered to be NMDA receptor antagonists, however their mechanism of action is usually far more complex, acting as either sigma/kappa opioid receptor agonists and/or GABA receptor agonists. Some of the common effects for most dissociative drugs can range from dream-like states of euphoria, to the complete separation from reality and one's body.

ArticleImageAlternative name(s)Chemical class(es)
3-MeO-PCP3-MethoxyphencyclidineArylcyclohexylamines, Dissociatives
4-MeO-PCP4-MethoxyphencyclidineArylcyclohexylamines, Dissociatives
Diethyl EtherC4H10O, EthoxyethaneDissociatives, Inhalants
DXMDextromethorphanDissociatives, Morphinan
Ketamine(RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanoneArylcyclohexylamines, Dissociatives
Methoxyketamine2-MeO-KetamineArylcyclohexylamines, Dissociatives
MethoxetamineMXE, 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanoneArylcyclohexylamines, Dissociatives
N-ethyl-nor-ketamineethylketamine, 2-(2-chlorophenyl)-N-(ethylamino)cyclohexanoneArylcyclohexylamines, Dissociatives
Nitrous OxideN2O, Laughing gas, NOSDissociatives, Inhalants
PhencyclidinePCPArylcyclohexylamines, Dissociatives


►►Empathogens are a class of psychoactive drugs which produce distinctive emotional and social effects such as feelings of empathy, love, and emotional closeness to others. The mechanism of action for most empathogenic drugs often times involves the release/reuptake inhibition of serotonin, norepinephrine, and/or dopamine in vary amounts depending on the compound at hand. The majority of entactogens share a similar chemical structure, belonging to the family of phenethylamines and often times containing a substituted amphetamine core.

ArticleImageAlternative name(s)Chemical class(es)
5-APB5-(2-aminopropyl)benzofuranAmphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
5-APDB5-(2-Aminopropyl)-2,3-dihydrobenzofuran Amphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
5-EAPB1-(Benzofuran-5-yl)-N-ethylpropan-2-amine Amphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
5-IAI5-iodo-2-aminoindaneAmphetamines, Entactogens
5-MAPB1-(benzofuran-5-yl)-N-methylpropan-2-amineAmphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
5-Methyl-MDA1-(7-methyl-1,3-benzodioxol-5-yl)propan-2-amineAmphetamines, Phenethylamines
6-APB6-(2-aminopropyl)benzofuran Amphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
6-APDB6-(2-Aminopropyl)-2,3-dihydrobenzofuran Amphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
6-EAPB1-(Benzofuran-6-yl)-N-ethylpropan-2-amine Amphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
6-MAPB1-(benzofuran-6-yl)-N-methylpropan-2-amine Amphetamines, Benzofuran, Empathogens, Entactogens, Phenethylamines, Psychedelics, Stimulants
6-Methyl-MDA1-(6-methyl-1,3-benzodioxol-5-yl)propan-2-amineAmphetamines, Phenethylamines
bk-MBDBβ-keto-N-methylbenzodioxolylpropylamine, ButyloneBeta-Ketones, Phenethylamines
bk-MDEAEthyloneAmphetamines, Beta-Ketones, Cathinones, Phenethylamines
bk-MDMA3,4-methylenedioxy-N-methylcathinone, Methylone, M1 Amphetamines, Beta-Ketones, Cathinones, Empathogens, Entactogens
Ecstasy3,4-methylenedioxy-N-methylamphetamineAmphetamines, Empathogens, Phenethylamines
MBDBMethylbenzodioxolylbutanaminePhenethylamines, Empathogens, Entactogens, Stimulants
MDA3,4-methylenedioxy-N-amphetamineAmphetamines, Phenethylamines
MDAI5,6-methylenedioxy-2-aminoindaneAmphetamines, Phenethylamines
MDAT6,7-methylenedioxy-2-aminotetralinAmphetamines, Phenethylamines
MDMA3,4-methylenedioxy-N-methylamphetamine, EcstasyAmphetamines, Empathogens, Entactogens, Phenethylamines
MMAI5-methoxy-6-methyl-2,3-dihydro-1H-inden-2-amineAmphetamines, Phenethylamines


►►Ethnobotanical are a category of psychoactive substances composed of by a wide class of plant life found in nature which are known to contain alkaloids that posses psychoactive effects in humans. The effects of ethnobotanicals can range greatly from one another and can include central nervous stimulants, depressants, hallucinogens, and antipsychotics. Likewise the mechanism of action for many ethnobotanicals can vary greatly as well from one to the next. Certain ethnobotanicals are known to carry scheduled substances such as N,N DMT, khat, and LSA.

ArticleImageAlternative name(s)Known active chemicals/Chemical class(es)
Blue LotusNymphaea caeruleaAporphine, Nuciferine
Betel nutAreca catechuArecatannin
CalamusAcorus calamusalpha-asarone
DamianaTurnera diffusaApigenin
Dream herbCalea zacatechichiAcacetin
IbogaTabernanthe ibogaIbogaine
Intoxicating MintLagochilus inebriansTerpineol, Lagochilin
KannaSceletium tortuosumMesembrine
Kava-KavaPiper methysticumKavalactones
KhatCatha edulisCathinones
KratomMitragyna speciosa7-Hydroxymitragynine
Lion's TailLeonotis leonurusLeonurine
Nepeta cataria Catnip 
Nutmeg Myristica fragrans 
Passion FlowerPassiflora incarnataBenzoflavone
Salvia divinorumSalvia divinorumSalvinorine A
Siberian motherwortLeonurus sibiricusLeonurine
SinicuichiHeimia SalicifoliaCryogenine
TobaccoNicotiana spp.Nicotine
Turbina corymbosa Ololiuqui, Rivea corymbosaLSA
Wild LettuceLactuca virosaLactucin
YohimbePausinystalia yohimbeYohimbine


►►Inhalants are a class of psychoactive substances which consist of a wide variety of gases that are administered via pulmonary absorption in order to achieve psychoactive effects. Inhalants have been known to posses both euphoric, and anesthetic effects, with the degree and duration of such effects being dependent on the substance administered. The gas lipid partition coefficient determines the potency of an inhalant. The higher this coefficient is, the more potent an inhalant is. The factor which determines the onset and comedown duration's of an inhalant is determined by its solubility in blood. The lower the blood solubility of an inhalant, the faster the onset and comedown duration's are. Inhalants are generally considered to be a dangerous class of chemicals and although no inhalant is perfectly safe, some are known to be much more dangerous than others.

ArticleImageAlternative name(s)Chemical class(es)
Amyl Nitrite(3-methylbutyl) nitriteAlkyl nitrites, Inhalants
Butane Alkane, Inhalants
1,1-DifluoroethaneComputer DusterFluorinated Hydrocarbon, Inhalants


►►Monoamine Oxidase Inhibitors (MAOI's) are a class of drugs which inhibit the activity of the monoamine oxidase enzyme families ability to breaks down monoamines, thus potentiating the effects of many tryptamines, phenethylamines, and other monoamine derived neurotransmitters. In medicine MAOIs are primarily utilized in the treatment of depression and Parkinson's syndrome, although some are also used to treat conditions such as social anxiety as well. Naturally MAOIs can be found in a variety of different plant sources, among these sources are Syrian Rue and Banisteriopsis caapi both of which contain Harmal and Harmaline, two compounds which inhibit the activity of MAO-A.


►►Nootropics are a broad class of drugs and supplements both from natural and synthetic sources which are administered for the main purpose of improving memory, cognition, and the physiological functions which occur within the body. Nootropics are generally considered to possess mild to moderate psychological effects, while having minimal to no side effects and an extremely low toxicity. Additionally nootropics are considered to lack the typical pharmacological aspects of a psychoactive drug such as stimulation or sedation though there are exceptions to this as in the case of Adderall, Methylphenidate, and Phenibut.

ArticleImageAlternative name(s)Chemical class(es)
AdderallAmphetamine saltsAmphetamines, Stimulants
Adrafinil OlmifonNootropics, Stimulants
Alpha GPC[(2S)-2,3-dihydroxypropyl] 2-trimethylazaniumylethyl phosphateCholine, Nootropics
Aniracetam1-[(4-methoxybenzoyl)]- 2-pyrrolidinone, Dragonon, SarpulRacetams, Nootropics
Bifemelane Alnert, CeleportNootropics
CentrophenoxineMeclofenoxateGlycolates, Nootropics
CiticolineCDP CholineNootropics, Stimulants
Choline2-hydroxy-N,N,N-trimethylethanaminiumQuaternary ammonium cation, Nootropics
Idebenone Avan, Catena, Daruma, Lucebanol, Mnesis, Prevage, SovrimaNootropics
Lisdexamfetamine Tyvense, Elvanse, Venvanse, VyvanseAmphetamines, Stimulants
MethylphenidateConcerta, Daytrana, Metadate, Methylin, Quillivant XR, Riphenidate, Ritalin, RitalinePiperidines, Stimulants
Modafinil(±)-2-(benzhydrylsulfinyl)acetamideEugeroics, Nootropics
Nefiracetam Nootropics, Antidementia agents, Racetams
Nicotine Heimia salicifoliaNootropics
NoopeptНоопепт; GVS-111Racetams, Nootropics
Oxiracetam(RS)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)acetamideRacetams, Nootropics, Stimulants
Picamilonnicotinoyl-GABAAnxiolytics, Stimulants, Nootropics
Piracetam2-oxo-1-pyrrolidine acetamideRacetams, Nootropics
Phenibut(RS)-4-amino-3-phenyl-butyric acidNootropics, Anxiolytics, Sedatives
Pramiracetam2-oxo-1-pyrrolidine acetamideRacetams, Nootropics
PRL-8-53  Nootropics
SelegilineDeprenylAmphetamines, MAOI


►►Opiates are the narcotic alkaloids found in opium (the latex released when immature seed-pods of the opium poppy, Papaver somniferum, are scored). Opium’s main alkaloids are morphine, codeine, noscapine, thebaine and papaverine, however it has a further approximately 25 minor alkaloids of unknown or negligible pharmacological value. Of all the opium alkaloids only morphine and codeine are considered true opiates. While thebaine is commonly classed as an opiate due to its chemical similarities with codeine and morphine, it lacks the typical narcotic effects associated with opiates, instead possessing stimulant type properties.

ArticleImageAlternative name(s)Chemical class(es)
CodeineMethylmorphine,Tylenol #1,#2,#3,#4Opiate, Analgesics, Antitussives, Sedatives, Hypnotics
MorphineMS Contin, RoxanolOpiate, Analgesics, Sedatives, Hypnotics
OpiumLaudanum, poppy teaOpiate, Latex, Sedatives, Hypnotics
PoppyPapaver somniferum Opiates, Papaveraceae
ThebaineParamorphine Opiate, Sedatives, Hypnotics


►►An opioid is either a fully-synthetic or semi-synthetic drug, created to mimic the pharmacological actions of a naturally occurring opiate alkaloid. These include all narcotic drugs that are derived from any of the alkaloids found within the opium poppy (Papaver Somniferum). Common examples of opioids are pain-relieving drugs such as the Codone and Morphone drug classes. However as mentioned earlier opioids can occur in either a semi-synthetic or fully-synthetic state, containing identical nitrogenous molecules which have a pharmacological effect similar to that of natural opiates on humans.

ArticleImageAlternative name(s)Chemical class(es)
BuprenorphineSuboxone, Subutex, Buprenex, TemegesicAnalgesics, Opioid
FentanylDuragesic, Actiq, FentoraAnilidopiperidines
Heroindiacetylmorphine, diamorphineAnalgesics, Opioid, Sedatives
Hydrocodonedihydrocodeinone, Vicodin, Lortab, Lorcet, VicoprofenMorphinones, Opioid
Hydromorphonedihydromorphinone, DilaudidMorphinones, Opioid
MethadoneDolophine, Polamidone, MethadoseAmidones, Opioid
MeperidineCentralgin, Demerol, Dispadol, Dolantin, Dolcontral, Dolosal, Dolsin, Isonipecaine, Lidol, Lydol, Meperidol, Nemerol, Operidine, Petantin, Pethanol, Pethidin, Pethidine, Pethidineter, Petydyna, Phetidine, Piperosal, Pipersal, PiridosalOpioid, Phenylpiperidines, Piperidines
OxycodoneOxycontin, Roxicodone, PercocetMorphinones, Opioid
Oxymorphone4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-oneMorphinones, Opioid
Tapentadol  Opioid
Tianeptine  Opioid
TramadolUltram, ZydolOpioid, Analgesics
U-47700  Opioid

[top]Piperazines / Piperidines

►►Piperazines/Piperidines are a broad range of both psychoactive and non-psychoactive compounds which share a common 6-membered ring, with 2 Nitrogen atoms opposing one another. Within the category of piperazines/piperidines exist many pharmacologically diverse compounds including some antidepressants, stimulants, and erectile dysfunction medications. Piperazines/Piperidines tend to have a common mechanism of action on the dopamine, serotonin, and norepinephrine receptors, often times acting as either reuptake inhibitors or releasing agents, though there are exceptions to this rule.

ArticleImageAlternative name(s)Chemical class(es)
2-DPMP2-diphenylmethylpiperidine; desoxypipradolPiperidines
Ethylphenidate Ethylcaine Piperidines, Stimulants
MethylphenidateConcerta, Daytrana, Metadate, Methylin, Quillivant XR, Riphenidate, Ritalin, RitalinePiperidines, Stimulants


►►Psychedelics are a category of hallucinogens which allow the mind to manifest itself by altering the users cognition and perception revealing aspects of reality that would otherwise go unnoticed or remain hidden. Derived from the Greek words ψυχή (psyche, soul, mind) and δηλείν (delein, to manifest) the term psychedelic essentially translates to soul-manifesting. The majority of psychedelic drugs have effects which are said to be somewhat comparable to temporarily disabling certain mental filters, allowing the user to experience many emotions, feeling, and ideas which would other wise be blocked out by the conscious mind. The majority of psychedelic substances have a common mechanism of action through the 5-HT serotonin system, acting as agonists on the serotonin receptors.

ArticleImageAlternative name(s)Chemical class(es)
1P-LSD 1-propionyl-LSDTryptamines
2C-B-FLY-NBOMeNBOMe-2C-B-FLY, Cimbi-31Phenethylamines
4-AcO-DET3-(2-Diethylaminoethyl)-1H-indol-4-yl acetateTryptamines
4-AcO-DMTO-Acetylpsilocin, 4-acetoxy-N,N-dimethyltryptamineTryptamines
25I-NBOMe2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine, BOM-CI, Cimbi-5Phenethylamines
Aeruginascin N,N,N-trimethyl-4-phosphoryloxytryptamineTryptamines
AyahuascaDMT + MAOI (from natural plant sources)Tryptamines, MAOI
Baeocystin 4-phosphoryloxy-N-methyl-tryptamineTryptamines
Bufotenin 5-OH-DMTTryptamines
ChacrunaPsychotria viridisTryptamines
EpenáVirola spp.Myristicaceae
EscalineE, 2-(4-Ethoxy-3,5-dimethoxy-phenyl)-ethylaminePhenethylamines
Hawaiian Baby WoodroseArgyreia nervosaTryptamines, Ergolines
Ibogaine 12-methoxyibogamineTryptamines
LSALysergic acid amideErgolines, Tryptamines
LSDLysergic acid diethylamideErgolines, Tryptamines
MimosaMimosa spp.Mimosoideae, Legume, Fabaceae
Morning GloryIpomoea spp.Tryptamines, Ergolines
Norbaeocystin 4-phosphoryloxytryptamineTryptamines
San PedroTrichocereus PachanoiPhenethylamines, Mescaline
PeyoteLophophora williamsiiPhenethylamines, Mescaline
PhalarisPhalaris spp. Grasses, Tryptamines
PharmahuascaDMT + MAOI (sometimes from synthetic sources)Tryptamines, MAOI
Salvinorine A   
YopoAnadenanthera peregrinaTryptamines


►►Stimulants are a class of psychoactive compounds which act on the central nervous system (CNS) in such a way as to temporarily improve the mental and/or physical functions of the user. Most central nervous system stimulants have a common mechanism of action through either the dopamine, norepinephrine, and/or serotonin pathways, typically acting as a reuptake inhibitor on the receptors. Some of the common effects of stimulants include increased wakefulness, enhanced cognitive function, alertness, and euphoria. Stimulants tend to carry a relatively high addiction potential, due mostly to their actions on the dopaminergic system.

ArticleImageAlternative name(s)Chemical class(es)
2-BA2-BromoamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
2-CA2-ChloroamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
2-DPMP2-diphenylmethylpiperidine; desoxypipradolPiperidines Stimulants
2-FA2-FluoroamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
2-IA2-IodoamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
3-BA3-BromoamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
3-CA3-ChloroamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines
3-FA3-FluoroamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
3-FMC3-fluoromethcathinoneBeta-Ketones, Cathinones, Phenethylamines, Stimulants
3-IA3-IodoamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
4-BA4-Bromoamphetamine, para-BromoamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
4-CA4-Chloroamphetamine, para-ChloroamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
4-FA4-Fluoroamphetamine, para-FluoroamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
4-IA4-Iodoamphetamine, para-IodoamphetamineAmphetamines, Halogenated Amphetamines, Phenethylamines, Stimulants
a-PVPα-PyrrolidinopentiophenoneCathinones, Beta-Ketones, Pyrrolidines
Amphetamine(RS)-1-phenylpropan-2-amineAmphetamines, Phenethylamines
CaffeineMethyltheobromine, NSC 5036Xanthine alkaloids, Stimulants
CocaineBenzoylmethyl ecgonineTropane Alkaloids, Stimulants
CocaErythroxylum CocaEthnobotanicals, Stimulants
Cocaethylene  Stimulants
CoffeeCoffea (arabica , canephora , et al)Xanthine alkaloids, Stimulants
CrackFreebase cocaineTropane Alkaloids, Stimulants
Dimethocaine(3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate,LarocaineAnesthetics, Stimulants
DMAAmethylhexanamine, 1,3-dimethylamylamineAliphatic amine, Stimulants
EphedraEphedra spp.Ethnobotanicals, Stimulants
Ethylphenidate Ethylcaine Piperidines, Stimulants
Flephedrone4-FMCBeta-Ketones, Cathinones, Phenethylamines
MDPPP3,4-methylenedioxy-alpha-pyrrolidinopropiophenonePhenethylamines, Pyrrolidines
MDPVmethylenedioxypyrovaleroneCathinones, Beta-Ketones, Pyrrolidines
Mephedrone4-MMC, 4-methylmethcathinoneBeta-Ketones, Cathinones, Phenethylamines
Methcathinone(RS)-2-(methylamino)-1-phenyl-propan-1-oneBeta-Ketones, Cathinones,Phenethylamines
Methedrone4-methoxymethcathinoneBeta-Ketones, Cathinones, Phenethylamines
MethamphetamineN-methylamphetamineAmphetamines, Phenethylamines
MethylphenidateConcerta, Daytrana, Metadate, Methylin, Quillivant XR, Riphenidate, Ritalin, RitalinePiperidines, Stimulants
MMDA5-methoxy-methylenedioxyamphetamineAmphetamines, Phenethylamines
NaphthylpyrovaleroneNaphyrone, 0-2482Beta-Ketones, Cathinones
Pentedrone(±)-1-phenyl-2-(methylamino)pentan-1-oneBeta-Ketones, Cathinones,Phenethylamines
PropylhexedrineBenzedrex, ObesinCycloalkylamines

[top]Miscellaneous Drugs

►►Miscellaneous drugs are drugs which do not necessarily meet the criteria required in order to be placed within a specific category under the "Psychoactive Substances & Plants" section. This is often the result of the compound having very minimal to no psychoactive effects, such as steroid type drugs, or serotonin reuptake inhibitors, which are often utilized before and after the administration of a serotonin releasing agent.

ArticleImageAlternative name(s)Chemical class(es)
5-HTP5-HydroxytryptophanAmino acid
Clonidine N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amineAlpha2-adrenergic receptor agonist, Imidazoline receptor agonist
DHEADehydroepiandrosteroneEndogenous steroid hormone, Steroid
Lofexidine2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazoleAnti-hypertensive, Alpha2-adrenergic receptor agonist
Oxymetholone  steroids

[top]Psychoactive Animals & Fungi

►►Psychoactive animals and fungi consist of a mixed group of both animals and fungi which are known to contain some sort of psychoactive compound. While the compounds found within the actual specimens are of relative significance, the main topic of this section is to highlight the natural life forms from which the compounds may be retrieved from. Additionally the compounds which are found within the animals and fungi listed in the following section vary drastically in chemical class from one to the other. Ranging from the typical central nervous system stimulant to a variety of hallucinogens all of which work through different mechanisms of action.

ArticleImageAlternative name(s)
Brazilian Wandering SpiderPhoneutria fera
Colorado River Toad Bufo alvarius
Dream fish Kyphosus fuscus, K. cinerascens, K. vaigiensis, Sarpa Salpa
Fly agaricAmanita muscaria
King CobraOphiophagus hannah
Magic MushroomsPsilocybe spp. et cetera

[top]Organizations & People


►►The fallowing list of organizations represent a large portion of the many different drug research, harm reduction and, anti prohibition organizations which are actively in operation educating the public, and determining the pharmacological properties, shot term/long term side effects, and danger profiles associated with many of the psychoactive substances used today.


►►The peoples sections consists of a mixed group of individuals whom in one way or another contributed to the world of psychoactive substances in some sort of manner. Whether they were/are chemists, researchers, or anti-prohibition activists the articles listed below contain a vast assortment of information on each of the following individuals personal lives, careers and notable events/accomplishments.


[top]Drug Testing Reagents

►►Drug testing reagents consist of an assortment of different chemical solutions which, when applied to an unidentified substance, react in a fashion which is unique to that of a specific chemical compound. Reagent testing can be particularly useful when attempting to identify an unknown substance or when attempting to rule out the possibility of an unwanted substance/contiminate. Reagent testing works by utilizing the process of elimination in order to potentially identify the chemical sample in question. Using a combination of several different chemical reagents along side a data sheet containing the reactions of said reagents, the results of each reaction is than cross referenced with the aformentioned data sheet in order to provide an appropriate assumption of what the sample in question may be. While reagent testing may help to provide a resonable guess towards what the identitity of said sample may be, they are highly unreliable as they do not eliminate the possibility of an additional compound or contaminates presence in the sample.

[top]Chemistry Guides

►►The drug chemistry guides features several articles which pertain to the basic concepts regarding the chemistry, synthesis, and extraction of a variety of different drugs or chemical classes. The featured articles give a very light introduction into the world of drug chemistry and do not/will not contain any synthesis routes, synthesis techniques, or any other talk regarding the creation of drugs in general. Further talk of drug chemistry should be discussed in the Drug Chemistry Forums.


[top]Routes of Administration

►►Route of administration is defined as the pathway by which a drug, fluid, poison, or other substance is introduced into the body. The section below highlights the routes of adminisration which are commonly utilized in order to successfully introduce a chemical compound into the systemic circulation of a living organism. Typically speaking each route of administration is placed into one of several different catagories, based on the location of the routes target of action.




►►Drug laws features a comprehensive list of information, categories, and articles which pertain to the legal aspects that are involved with the production, distribution, sales and use of psychoactive substances in a variety of different regions, countries, and states throughout the world. The laws covered within this section can include the regulation of controlled substances, medicines, and dangerous goods in addition to highlighting the laws regarding the definition of drug analogs, the possession of drug paraphernalia, and the legal consequences which are involved with driving under the influence.

[top]Recovery and Addiction

►►The recovery and addiction section features a series of comprehensive articles which range from specific drug addictions to general drug addiction treatment guides. Within these guides can be found information on a variety of different subjects such as the mental and physical effects of addiction, the dangers involved with addiction, the social effects pertaining to said addiction, the current medical diagnosis for addiction, as well as the withdrawal symptoms associated with addiction and much more. Additionally the recovery and addition section contains articles which help to provide a general overview of the troubles which are often faced by drug addicts, as well as the options for which they can take in order to receive treatment.


[top]Miscellaneous Articles

►►The miscellaneous articles section features an assortment of guides which greatly range in topic from one to the next and contain a wealth of information which is considered to be extremely unique and detailed on the specific topics for which they cover. Each article within this section has been meticulously crafted by one or more members to produce an extremely informative piece of literature which can and will greatly benefit the reader.



►►The categories listing contains an assortment of categories which are commonly found in the categories section of each drug wiki. Additionally each category article provides a general overview on the specific topic including information such as the categories classifications, mechanisms of action, routes of administration, effects, combinations, uses, chemistry data, dangers of use, production data, and legal statuses for a variety of different countries along with an alphabetical listing of all the drug wiki's which are tagged with said category.


►►The drug dictonary contains and index of terms, definitions, and articles which are commonly associated with the chemistry, pharacology, and consumption of many psycoactive substances. The topics found within the drug dictonary range greatly, from mechanisms of action to effects and side effects, the drug dictionary features a wide variety of wiki articles which are not listed on main wiki page.

[top]Contributing to the Wiki

NOTE: Red links are links to articles that need to be created. Do not click on a red link and start a new article, it will be created in the wrong location. Go to this page, Writing a Wiki Article, and use the "New Thread" button for the article. You will also find the correct templates for articles there.

Silver and Donating Members can start and edit wiki articles, though some may be subject to moderation approval. Writing a Wiki Article outlines the categories and classifications for Wiki articles and includes links to appropriate templates. The Wiki FAQ article have more information on how to write, edit, and contribute to the Drugs Wiki.

The Wiki Writers social group is for those interested in discussing the drugs wiki and helping maintain a high level of accuracy and quality. New members are welcome, and suggestions on improving the Wiki are also welcome, whether or not you decide to actively edit or maintain a Wiki.

The Drugs-Wiki discussion forum is where all articles-in-progress should be posted first.

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