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[top]Introduction to Mecke reagent

Its advantage is that it can test for 2C-T-xx compounds (e.g. 2C-T-7 or 2C-T-21), DXM and opiates.
Tests for: MDxx, DXM, opiates, and 2C-T-xx.
The Simon's and Robadope reagents can be used to distinguish between substances in a family, for example between MDA and MDMA. They should be used in conjunction with another more versatile reagent if one does not know what substances are present in the powder or pill, but they are sufficient if e.g. one knows that the substance is either MDE or MDMA.

[top]Testing with Mecke reagent

One can apply a few drops of the Mecke reagent to a sample of the compound on glass or ceramic. Be careful with test regents, they can be corrosive. Handle in a well ventilated area, gasses can emerge from the reaction.

Observe the color change. Compare with chart below. [1]

[top]Known color changes with Mecke reagent

Diacetylmorphine HCl Deep bluish green
Dimethoxy-meth HCl Dark brown
Doxepin HCl Very dark red
Dristan powder Light olive brown
Exedrine powder Dark grayish yellow
Hydrocodone tartrate Dark bluish green
LSD Greenish black
Mace5 crystals Dark grayish olive
MDA HCl Very dark bluish green
Mescaline HCl Moderate olive
Morphine monohydrate Very dark bluish green
Nutmeg leaves Brownish black
Opium Powder Olive black
Oxycodone HCl Moderate olive
Propoxyphene HCl Deep reddish brown
Sugar crystals Brilliant greenish yellow

[top]Making Mecke reagent

Dissolve 1.0 g of selenious acid in 100 mL of concentrated sulfuric acid. [2]

[top]Danger of the Mecke reagent

1. Selenious acid OXIDIZER, TOXIC. Highly toxic. Contact with combustible
material may cause fire. Toxic by inhalation, in contact with skin, and if swallowed.
Irritating to eyes, respiratory system, and skin. Target organs: liver, heart. Keep away from combustible material. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Take off immediately all contaminated clothing. Wear suitable protective clothing, gloves, and eye/face protection.[2]

2. Sulfuric acid - OXIDIZER, ACID, TOXIC, CORROSIVE. Liquid and mist
cause severe burns to all body tissue. May be fatal if swallowed. Harmful if inhaled.
Inhalation may case lung damage. Do not get liquid in eyes, on skin, or clothing. Wash thoroughly after handling. Avoid breathing vapors. Use with adequate ventilation. Do not add water to contents while in container because of violent reaction. Store in tightly closed container. Wear suitable protective clothing and gloves.[2]

[top]How the Mecke reagent works

This section needs to be written. Please contact NeuroChi if you would like to help.

The reactions induced by Mecke reagent are much less known than the reactions produced by the Marquis reagent. So far, the reaction has been elucidated for morphine (and therefore morphine derivatives). This section will therefore focus on describing the chemical reactions of selenious acid, then will give some indications about potential reactions occuring. The proposed reaction for morphine will conclude, along with additional notes.

[top]Reactions involving selenium dioxide

While the Mecke reagent involves the use of selenious acid, it should be noted that it is equivalent to selenium dioxide. Indeed, selenious acid (OSe(OH)2 = SeO2 + H2O) is the hydrated form of selenium dioxide (SeO2).

Selenium dioxide is used as an oxidizer in organic chemistry. Its reactions involve the oxidization of aldehydes and ketones into α-dicarbonylates derivatives, and allyl oxidization of alkenes.

[top]Oxidization of aldehydes and ketones

[top]Allylic oxidization

[top]Potential reactions involved with drug molecules

[top]Reaction of morphine with Mecke reagent

Morphine (1) firstly undergoes an acid-catalyzed rearrangement into apomorphine (2). Apomorphine (an ortho-hydroquinone) is then oxidized into the corresponding ortho-quinone (3). (3) is the compound responsible for the green coloration.

[top]Additional notes

[top]Compounds tested with Mecke reagent

The following is a list of compounds tested by Drugs Forum members with the Mecke reagent.

Verified refers to whether or not the compound was verified by a third party lab (ie. GC/MS results confirm).

Color refers to the best description of the color either by image upload or user(s) description. Please see the thread linked for more information.

Compound Verified? Color Other notes
4-FA [1] no Brown / dark drown  
4-FA [2] no Brown  
4-FA [3] no Brown user believes this is 4-FA
4-FMA [1] no Dark red / brown at first, green if diluted user comments this compound is barely active in high doses
6-APB [1] no Yellow user describes this compound as supposedly 6-APB, though very impure
JWH-073 [1] no yellow > yellow/orange  
JWH-081 [1] no dark red/brown  
JWH-250 [1] no bright red  
MDPV [1] no Dark red / brown no rxn to Simons or Robadope, implies tertiary amine (MDPV)
MDPV [2] no Dark brown no rxn to Simons or Robadope, implies tertiary amine (MDPV)
Methylone [1] no Orange
Naphyrone [1] no Dark red / brown rxn to Simons, implies secondary amine (not Naphyrone)


  1. ^ EZ Test Mecke: The classic test for ecstasy. EZ Test. Located here: http://www.eztest.com/dir2/ez-test-mecke-the-classic-test-for-ecstasy. (Accessed July 29, 2011).
  2. ^ a b c Reagent A.10. Colour Test Reagents-Kits for Preliminary Identification of Drugs of Abuse. National Institute of Justice.

Attached Images
File Type: jpg ez_mecke.jpg (21.4 KB, 506 views)
Contributors: John_bob, NeuroChi
Created by NeuroChi, 29-06-2011 at 17:39
Last edited by John_bob, 19-10-2014 at 14:10
Last comment by NeuroChi on 29-06-2011 at 17:46
1 Comments, 16,167 Views

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