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[top]Introduction to Mescaline

Mescaline, 3,4,5-trimethoxyphenethylamine, is the main active phenethylamine in several cacti native to Mexico and South America including Peyote (Lophophora williamsii), San Pedro (Echinopsis pachanoi), and Peruvian Torch (Echinopsis peruviana).

It is a psychedelic hallucinogen often compared to psilocybin and LSD because it mimics serotonin and binds primarily to the 5-HT2A receptors, however mescaline is the least potent of the three. The hallucinations are similar to that of magic mushrooms, but can last significantly longer.

Peyote has been used for spiritual purposes by various tribes of Native Americans of Mexico. Though mescaline is illegal, members of the Native American Church are exempt from federal law and allowed to consume Peyote for religious purposes.

[top]Using Mescaline

[top]Ways of administration:

An average dose is between 200-500mg.
The effects last 4-12 hours.

[top]Effects of Mescaline

Describe the effects, side effect, after effects.

[top]Combinations with Mescaline

Describe which combinations are possible or known.
Describe the effects, side effect, after effects.

[top]Different Uses for Mescaline

i.e. medical, recreative, erotic, etc.

[top]Pharmacology of Mescaline

LD50 (mg/kg) [1] :
- Freebase
Rat : 370 intraperitoneally
- Hydrochloride
Mice : 212 intraperitoneally
Rat : 132 intraperitoneally
Guinea pig : 328 intraperitoneally

[top]Chemistry of Mescaline

Systematic (IUPAC) name:2-(3,4,5-trimethoxyphenyl)ethanamine
Synonyms:3,4,5-trimethoxybenzeneethanamine, 3,4,5-trimethoxyphenethylamine, mezcaline
Molecular Formula:C11H17NO3, C11H17NO3.HCl (hydrochloride), (C11H17NO3)2.H2SO4.2H2O (sulfate dihydrate), C11H17NO3.H2SO4 (acid sulfate)
Molar mass: 211.26 g/mol, 247.72 g/mol (hydrochloride), 556.62 g/mol (sulfate dihydrate), 309.34 g/mol (acid sulfate) [2]
CAS Registry Number:54-04-6, 832-92-8 (hydrochloride), 1152-76-7 (sulfate dihydrate)
Melting Point:35-36C, 181C (hydrochloride), 183-186C (sulfate dihydrate), 158C (acid sulfate), 94C (N-acetylmescaline)[1]
Boiling Point:180C @ 12 mmHg[1]
Flash Point:no data
Solubility:Freebase : soluble in alcohol, chloroform, benzene[1], acetone[3]; moderately soluble in water; practically insoluble in ether, petroleum ether[1]. Hydrochloride : soluble in water, alcohol[1][3]; insoluble in acetone, ether, hexane[3]. Sulfate dihydrate : soluble in hot water, methanol; sparingly soluble in cold water, ethanol[1]; insoluble in acetone, chloroform, ether, hexane[3].
Additionnal data:none
Notes:Freebase takes up CO2 from the air and forms a crystalline carbonate. Hydrochloride aspact : needles. Sulfate dihydrate aspect : prisms.[1]
Mescaline acetate salt has been synthetized. This salt is very soluble in water. Maybe hydrated.

[top]Reagent test results of Mescaline

Reagent color produced picture video
Marquis Orange[3] link -
Mecke Greenish brown changing to brown[3] - -
Mandelin Green to violet to gray[3] - -
Liebermann's Black[3] - -
Froehde's Brown fading to colorless[3] - -
Vitali's Dull red Purple/dull red/brown[3] - -

[top]The dangers of Mescaline

Describe the addiction potential, toxicity and other risks.
Describe problems and risks that arise with Overdose, side-effects, long term effects.
Describe problems with combining the drug.

[top]Producing Mescaline

Mescaline Synthesis

Mescaline Extraction

[top]Forms of Mescaline

Chemical data

[top]Legal status of Mescaline

Mescaline is a controlled substance 21 CFR 1308.11

[top]United Nations

Describe the legal situation according to the UN treaties. See: http://www.unodc.org/enl


Schedule I drug, In the United States, mescaline was made illegal in 1970 by the Comprehensive Drug Abuse Prevention and Control Act


Describe the legal situation in the EU. See: http://europa.eu/scadplus/leg/en/lvb/l33215.htm

Describe the legal situation in other countries. See: http://www.unodc.org/enl/browse_countries.jsp

[top]History of Mescaline

Describe the history of the drug from an international perspective. NOT from a USA perspective.

[top]More Mescaline Sections

Mescaline Experiences Post & read experiences with Mescaline.

Mescaline extraction & synthesis Post and read about Mescaline chemistry.

Mescaline File Archive Upload and read research & articles on Mescaline.

Mescaline Forum Post and read about Mescaline.

[top]The latest Mescaline threads

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  1. ^ a b c d e f g h Merck Index, fifteenth edition (2013)
  2. ^ Calculated from Atomic Weights of the Elements, 2007
  3. ^ a b c d e f g h i j Mescaline monograph

Created by NeuroChi, 15-02-2010 at 05:09
Last edited by John_bob, 14-06-2015 at 13:23
Last comment by catseye on 05-12-2011 at 14:07
7 Comments, 66,330 Views

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