[top]Introduction to Mescaline
, is the main active phenethylamine in several cacti native to Mexico and South America including Peyote
), San Pedro
, and Peruvian Torch (Echinopsis peruviana)
It is a psychedelic
hallucinogen often compared to psilocybin
because it mimics serotonin
and binds primarily to the 5-HT2A receptors, however mescaline is the least potent of the three. The hallucinations are similar to that of magic mushrooms, but can last significantly longer.
Peyote has been used for spiritual purposes by various tribes of Native Americans of Mexico. Though mescaline is illegal, members of the Native American Church are exempt from federal law and allowed to consume Peyote for religious purposes.
[top]Ways of administration:
An average dose is between 200-500mg.
The effects last 4-12 hours.
[top]Effects of Mescaline
[top]Combinations with Mescaline
Describe which combinations are possible or known.
Describe the effects, side effect, after effects.
[top]Different Uses for Mescaline
i.e. medical, recreative, erotic, etc.
[top]Pharmacology of Mescaline
LD50 (mg/kg)  :
Rat : 370 intraperitoneally
Mice : 212 intraperitoneally
Rat : 132 intraperitoneally
Guinea pig : 328 intraperitoneally
[top]Chemistry of Mescaline
|Systematic (IUPAC) name:||2-(3,4,5-trimethoxyphenyl)ethanamine|
|Synonyms:||3,4,5-trimethoxybenzeneethanamine, 3,4,5-trimethoxyphenethylamine, mezcaline|
|Molecular Formula:||C11H17NO3, C11H17NO3.HCl (hydrochloride), (C11H17NO3)2.H2SO4.2H2O (sulfate dihydrate), C11H17NO3.H2SO4 (acid sulfate)|
|Molar mass:|| 211.26 g/mol, 247.72 g/mol (hydrochloride), 556.62 g/mol (sulfate dihydrate), 309.34 g/mol (acid sulfate) |
|CAS Registry Number:||54-04-6, 832-92-8 (hydrochloride), 1152-76-7 (sulfate dihydrate)|
|Melting Point:||35-36°C, 181°C (hydrochloride), 183-186°C (sulfate dihydrate), 158°C (acid sulfate), 94°C (N-acetylmescaline)|
|Boiling Point:||180°C @ 12 mmHg|
|Flash Point:||no data|
|Solubility:||Freebase : soluble in alcohol, chloroform, benzene, acetone; moderately soluble in water; practically insoluble in ether, petroleum ether. Hydrochloride : soluble in water, alcohol; insoluble in acetone, ether, hexane. Sulfate dihydrate : soluble in hot water, methanol; sparingly soluble in cold water, ethanol; insoluble in acetone, chloroform, ether, hexane.|
|Notes:||Freebase takes up CO2 from the air and forms a crystalline carbonate. Hydrochloride aspact : needles. Sulfate dihydrate aspect : prisms. |
Mescaline acetate salt has been synthetized. This salt is very soluble in water. Maybe hydrated.
[top]Reagent test results of Mescaline
|Reagent || color produced|
|Marquis || Orange|
|Mecke || Greenish brown changing to brown|
|Mandelin || Green to violet to gray|
|Liebermann's || Black|
|Froehde's || Brown fading to colorless|
|Vitali's || Dull red Purple/dull red/brown|
[top]The dangers of Mescaline
Describe the addiction
potential, toxicity and other risks.
Describe problems and risks that arise with Overdose, side-effects, long term effects.
Describe problems with combining the drug
[top]Legal status of Mescaline
Mescaline is a controlled substance 21 CFR 1308.11
[top]History of Mescaline
Describe the history of the drug from an international perspective. NOT from a USA perspective.
[top]More Mescaline Sections
[top]The latest Mescaline threads
 Calculated from Atomic Weights of the Elements
 Merck Index
, fifteenth edition (2013)
 Mescaline monograph
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