is a euphoriant, stimulant, and aphrodisiac closely related to amphetamine
but more potent and longer-lasting. Unlike amphetamine, it is directly toxic to dopamine
neurons, with hyperthermia
aggravating its toxicity. It is highly addictive, with prolonged abuse capable of causing serious health problems including depression, anhedonia, psychosis, Parkinson's disease and cardiac damage. In the United States the dextro isomer, which is Schedule II, is prescribed under the brand name Desoxyn for narcolepsy and ADHD, although this is uncommon due to the stigma associated with the drug
and the availability of alternatives. In contrast, the levo isomer is available over the counter as a component of Vicks Vapor Inhaler wherein it functions as a vasoconstrictor, with little if any effect on the central nervous system.
[top]Introduction to Methamphetamine
Methamphetamine or crystal meth is a long acting, powerful and addictive stimulant closely related to amphetamine. Longer lasting and more toxic in its effects on the central nervous system than amphetamine itself, methamphetamine has a high potential for abuse and addiction
. Methamphetamine is a white, odorless, bitter-tasting crystalline powder that easily dissolves in water or alcohol
and is taken orally, intra nasally (snorting
the powder), by needle injection, or by smoking. Methamphetamine causes euphoria
, increased wakefulness and physical activity and decreased appetite. Chronic, long-term use can lead to psychotic behavior, hallucinations, stroke or heart attack.
[top]Ways of administration
People generally have a preferred way of administering methamphetammine, often favoured because of a desired higher bioavailability, and sometimes for the ritual(s) it involves.
- Methamphetamine is smoked, either out of a glass bowl and stem, or off of some kind of foil. This is the most common ROA due to it's high bioavailability(~90.3%) without the risks of injection, or the discomfort of insufflation
- Just as snorting most other substances, This produces a quick but short lived peak followed by a few hours of coasting. Many users report the effects of insufflation last much longer than smoking . The bioavailability is a surprisingly low ~79%.
- This is a popular ROA among long time users for it's quick intense rush and the 100% bioavailability. The risks of injecting street methamphetamine are very high. A regular user is at risk of developing pulmonary embolism (PE), a blockage of the main artery of the lung or one of its branches, and commonly develop skin rashes (also known as "speed bumps") or infections at the site of injection. One also risks putting "cut" into their veins when this is done.
- This ROA is often used for it's discreet nature. Users will sometimes empty Tylenol capsules and fill them with Methamphetamine for public use. This is the safest way to ingest methamphetamine, presenting the least amount of risk factors. The only common factor being the substance itself, not taking into consideration each persons individual risk factors. Oral bioavailability of methamphetamine is ~62.7.
- This is an uncommon ROA, due to the stigma associated with putting drugs
into the rectum (outside of medical contexts). Plugging methamphetamine involves inserting the drug into the anus (or vagina) directly, via capsule, or by dissolving it in water and using a hypodermic syringe with the needle removed to squirt the resulting methamphetamine solution into the rectum. Some users report increased sexual satisfaction with this method of administration. Methamphetamine will have a fairly easy onset with a high peak, a long coast and an easy comedown
. The bioavailability of suppository methamphetamine use is ~99%
[top]Effects of Methamphetamine
The typical effects of methamphetamine in low doses are improved mood or euphoria, increased alertness, wakefulness and concentration, increased sociability, creative stimulation (i.e. music, writing, art), decreased appetite, increased libido, feelings of confidence, freedom from care, and interest in even otherwise mundane things and activities. Large doses of methamphetamine have been observed to cause psychosis, rhabdomyolysis
, cerebral hemorrhage, life-threatening hyperthermia above 41°C, renal and liver failure, cardiac arrhythmias, heart attacks, cerebrovascular hemorrhages, strokes and seizures.
As a black market substance methamphetamine is variable in its method of production and quality from one batch to another. Different types of crystal methamphetamine, and quality of crystal methamphetamine can greatly differ from country to country, and even city to city. This variability means the effects of methamphetamine are not going to be uniform. Methamphetamine can also provide different effects as a function of the route of administration used.
Since users of meth often stay awake for long periods of time, the effects experienced during the inital onset can be quite different than the effects experienced during the end of a methamphetamine binge.
[top]Combinations with Methamphetamine
Methmphetamine should not be used with monoamine oxidase inhibitors
(MAOIs) or for 14 days following their administration; taking them together may cause serious enough high blood pressure
to result in serious organ damage.
CYP2D6 inhibitors (e.g., selective serotonin reuptake inhibitors
(SSRIs)) prolong the effects of methamphetamine by slowing its metabolism and thereby prolonging its half-life
. Methamphetamine may decrease the effects of CNS depressants
and increase the effects of stimulants
. Methamphetamine may counteract the effects of antihypertensives and antipsychotics. Because methamphetamine absorption is pH-dependent, proton pump inhibitors, which reduce gastric acid, interact with methamphetamine to lengthen its half-life.
[top]Different Uses for Methamphetamine
Methamphetamiine (as Desoxyn, methamphetamine hydrochloride tablets) is approved in the USA as an adjunct in treatment of Attention Deficit Disorder with Hyperactivity (a behavioral syndrome characterized by moderate to severe distractibility, short attention span, hyperactivity, impulsivity, and emotional instability, where all are severe enough to be problematic and inappropriate to the developmental stage of the child) in children 6 years or older. Therapeutic doses typically start at 5 mg once or twice a day, these then may be raised in increments of 5 mg until optimal effects are seen; the typical effective dose of methamphetamine for ADHD is 20 to 25 mg daily.
Methamphetamine (in the form of Desoxyn) is also approved in the USA for short term treatment of obesity that is refractory (has not responded to) other treatments including diets, groups programs or other drugs. This treatment has been shown effective only for a matter of several weeks, methamphetamine's suppression of appetite being quickly subject to tolerance effects.
[top]Pharmacology of Methamphetamine
(mg/kg) (as the hydrochloride)  :
Mice : 70 intraperitoneally
Methamphetamine is a sympathomimetic amine with stimulating effects in both the central and peripheral nervous system including elevation of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. In humans, orally administered methamphetamine reaches peak blood levels 3-6 hours after ingestion. Because methamphetamine is highly lipophilic it crosses the blood brain barrier and will cross the placenta to directly affect fetal tissues and nervous system. Methamphetamine is mainly metabolized in the liver by aromatic hydroxylation, N-dealkylation and deamination and has at least seven metabolites. The elimination half-life of methamphetamine is 10-12 hours. Methamphetamine excretion occurs mostly via urine and is dependent on urine pH, higher pH (alkaline) urine significantly increases methamphetamine half-life by reducing the rate of elimination. Close to two-thirds of an oral dose is excreted in the urine within the first 24 hours with about two-thirds of that as metabolites and one-third as methamphetamine.
Once in the brain methamphetamine causes a cascading release of norepinephrine, dopamine and serotonin
. Methamphetamine increases dopamine and serotonin release from storage vesicles (reverse transport) and blocks their uptake, thereby increasing their cytoplasmic concentrations and making them more readily available for reverse transport. The net consequence of an acute dose of methamphetamine is increased neurotransmission of norepinephrine, dopamine and serotonin.
[top]Chemistry of Methamphetamine
|Systematic(IUPAC) name:||(S) (+)-N-methyl-1-phenylpropan-2-amine|
|Synonyms:||(αS)-N,α-dimethylbenzeneethanamine, (S)-(+)-N,α-dimethylphenethylamine, d-N-methylamphetamine, d-deoxyephedrine, d-desoxyephedrine, 1-phenyl-2-methylaminopropane, d-phenylisopropylmethylamine, methyl-ß-phenylisopropylamine, Norodin; Amphedroxyn, Desfedrin, Desoxyfed, Desoxyn, Destim, Doxephrin, Drinalfa, Gerobit, Hiropon, Isophen, Madrine, Methamphex, Methedrine, Methylisomyn, Pervitin, Soxysympamine, Syndrox, Tonedron, "speed", "meth", "ice" (hydrochloride)|
|Molecular Formula:||C10H15N, C10H15N.HCl (hydrochloride)|
|Molar mass:||149.24 g/mol, 185.70 g/mol (hydrochloride)|
|CAS Registry Number:|| 537-46-2, 51-57-0 (hydrochloride)|
|Melting Point:||170-175℃ (hydrochloride)|
|Boiling Point:||no data|
|Flash Point:||no data|
|Solubility:||freely soluble in water, alcohol, chloroform; very slightly soluble in absolute ether|
|Notes:||hydrochloride aspect : white crystals; bitter taste|
The name methamphetamine commonly refers to the hydrochloride salt.
[top]The Dangers of Methamphetamine
[top]Physical Health Risks
Persistent reductions in most dopamine and serotonin markers have been observed in chronic methamphetamine users. Repeated high doses of methamphetamine have been shown to cause long-lasting reductions in nerve terminal levels of dopamine and serotonin, their metabolites, associated enzymes, their receptors, and their transporters. Methamphetamine has also been shown to produce morphological signs of axonal degeneration, and morphological studies have suggested that the reductions of dopamine and serotonin markers are related to destruction of the axons and axon terminals but not the bodies of the neurons themselves. These neurotoxic effects of methamphetamine appear to be ambient and core body temperature dependent, with higher temperatures associated with greater damage.
Methamphetamine seems to most severely affect dopamine terminals in the striatum, and at most minimally damage dopamine terminals in the nucleus accumbens, olfactory bulb, frontal cortex, and hypothalamus, possibly because of differing densities of dopamine and its transmission in these brain regions. The damage methamphetamine does to serotonin terminals in various brain regions including hippocampus, prefrontal cortex, amygdala, and striatum appears to be of equal severity.
There have been reports of increased blood pressure, increased heart rate, stroke and heart attack in adults, and sudden death in patients who have heart problems or heart defects with use of methamphetamine and other stimulants. Repeated use of methamphetamine can also lead to coronary heart disease and cardiomyopathy. People with heart problems, heart defects, high blood pressure or a family history of these should avoid use of methamphetamine and if prescribed desoxyn ensure their doctor knows of these.
[top]Seizures and other neurological problems
Some reports have indicated that stimulant use can lower seizure thresholds in patients with a history of seizure, patients with EEG abnormalities but no seizure, and, in rare cases, in patients with neither seizure history nor abnormal EEG. A lowered seizure threshold increases risk of seizure. Amphetamines
have been reported to worsen motor and phonic tics in Tourette’s syndrome.
[top]Circulation problems in fingers and toes
There have been reports of circulatory problems in the extremities (Peripheral vasculopathy, including Raynaud’s phenomenon) associated with the use of methamphetamine. Symptoms include numbness, cold, pain, and change in colour from pale to blue, to red in fingers and/or toes. Anyone experiencing these symptoms should seek medical attention.
Methamphetamine overdoses typically cause restlessness, tremor, severely high blood pressure, hyperreflexia, rapid breathing, confusion, aggression, hallucinations, panic, hyperpyrexia, and rhabdomyolysis. After the stage of excessive central nervous system stimulation fatigue and depression often occur. Overdose of methamphetamine can cause heart arrhythmias, high or low blood pressure, and circulatory collapse. Methamphetamine overdose also causes nausea, abdominal cramping, vomiting, and diarrhea. In cases of fatal poisoning death is typically preceded by convulsions and coma.
Fatalities have been reported associated with methamphetamine use, abuse and overdose. Methamphetamine related deaths often involve cardiovascular complications and these are more likely to occur with injection and smoking of methamphetamine than other routes of administration
. In the majority of methamphetamine toxicity related deaths other substances are also found to be present, most frequently opiates
/opioids or benzodiazepines
. Methamphetamine toxicity does not appear to have a clear dose–response, methamphetamine toxicity related death is associated with both low or high levels of methamphetamine in the blood. Post mortem blood levels of methamphetamine in one study suggest that a fatally toxic dose is >150mg. Reports suggest methamphetamine-related deaths frequently involve multiple congestion, pulmonary oedema, pulmonary congestion, cerebrovascular haemorrhage due to high blood pressure, ventricular fibrillation, acute cardiac failure or hyperpyrexia. Methamphetamine deaths due to septic injection or asphyxia by aspiration of vomit have also been reported. A large proportion of methamphetamine-related fatalities arise from accidents, suicide and homicides, rather than physical causes directly attributable to methamphetamine toxicity. This suggesting toxic methamphetamine doses pose risk of severe psychological and behavioural disturbances.
Sudden deaths, fatal stroke, and hearts attacks have also been reported in adults taking stimulant drugs at usual doses for ADHD.
[top]Mental Health Risks
[top]Psychosis, new or worsened mental illness and suicidal thinking
Reports of new and increased mental illness and symptoms are associated with use of stimulant drugs at regular prescribed doses, including aggressive behaviour and hostility, bipolar depression, mania, psychosis and psychotic symptoms such as hallucinations (particularly auditory) and delusions. One study found that psychotic and manic symptoms in patients without a history of psychosis or mania were rare, happening at a rate of about 1 in 1000. Methamphetamine use by patients with bipolar disorder may worsen or trigger a manic episode. Use of methamphetamine by patients with a preexisting psychotic disorder can can increase and worsen their behavioural and thought disturbances.
Recreational use of methamphetamine typically involves higher than therapeutic doses and exhibits a pattern of bingeing, and hence is likely to present higher risk of psychotic or manic symptoms even in those with no history. Clinical data show that methamphetamine binges can result in psychosis but it is not known whether this psychosis is purely the result of the amount ingested in a dose or over the binge, or due to a triggering of pre-existing vulnerability in some methamphetamine users, a combination of these, or the result of methamphetamine related sleep deprivation. Over 25% of those initially diagnosed with methamphetamine induced psychosis after some years developed a primary psychotic disorder, suggesting at least some cases may involve preexisting vulnerability. It has been demonstrated that amphetamines can trigger psychosis in healthy subjects given consecutively higher doses. Though psychosis did not occur in 100% of subjects, it usually occurred after 100–300 mg of amphetamine. But studies indicate only a weak relationship between stimulant psychosis and blood levels of amphetamines.
Methamphetamine should be avoided by those with depression, bipolar illness, psychosis or a history of suicidal thinking or attempts. Any patient prescribed methamphetamine (desoxyn) with a history of depression, bipolar illness, psychosis or a history of suicidal thinking or attempts must ensure their doctor knows of it.
Some studies have found that chronic recreational methamphetamine use is associated with a range of cognitive impairments, including deficits in attention, working memory, and decision-making.
The effects of an acute dose of methamphetamine, however, include improved cognitive functioning in some areas of cognition, for example visuospatial perception, attention, and inhibition.
Common side effects
of methamphetamine use include increased blood pressure, tachycardia
, heart palpitations, decreased appetite, tremors or shakes, excessive sweating, headache, insomnia (trouble sleeping), dizziness, stomach upset, increase of motor and phonic tics of Tourette’s syndrome, weight loss, joint and muscle pain, impotence and changes in libido, frequent or prolonged erections, and dry mouth.
Chronic abuse of methamphetamine can lead to anxiety, depression, aggressiveness, social isolation, psychosis, mood disturbances, and psychomotor dysfunction
Suppression of growth has been shown to be a side-effect of long-term use of stimulants in children, specifically methylphenidate
. Though not established by data (yet) common sense urges caution and an expectation that this could also be a side-effect of long term methamphetamine (desoxyn) use in children.
Methamphetamine use over extended periods leads to tolerance and dependence. Stopping such chronic methamphetamine use, especially abruptly and/or after long term use at high doses can cause extreme fatigue or tiredness, depression, disruptions of sleep.
Prolonged methamphetamine use leads to tolerance and extreme psychological dependence. Withdrawal
from methamphetamine can produce anhedonia (loss of any feelings of pleasure), irritability, fatigue, impaired social functioning, and intense craving for methamphetamine.
[top]Forms of Methamphetamine
Methamphetamine is generally found in one of two optical isomers, or a mix of the two, called a racemic mixture. The configuration is relative to the order of placement of the groups on a chiral carbon of the compound.
The D and L are the optical isomers (enantiomers) associated with methamphetamine and are defined based on how polarized light deflects them. The deflection of light is either positive (dextrorotory) or negative (levorotatory). These isomers do not change the entire configuration of the molecule, but do change the order in which they make the molecule appear in a 3D image of the compound. These two isomers are also found in MDMA
and amphetamine and are often dictated by the manufacture process and the intermediates used in that process.
Ephedrine used as a precursor to meth will produce d-methamphetamine, whereas methamphetamine produced with P2P (phenylacetone) will produce the a racemate, a mixture of the two enantiomers, d and l-methamphetamine in equal proportions. Old timers in the meth scene will attest to the desire of using d-meth over the more commonly found l-methamphetamine.
The way the different isomers of meth effect the body is relative to the way they bind to the receptors on the brain as d-meth will bind more efficiently than the l-meth. When the remnants of l-meth does not bind as nicely as d-meth, it is metabolized faster than the d-meth (which is still hard at work pleasuring the user) and is broken down faster to hydroxyl substituted compounds and excreted out of the body faster.
Methamphetamine can be found in different physical consistencies. These are relative to the way the chemist (or cook in most cases) goes about forming the crystal during the last stage of the production process. Methamphetamine that is powdery in consistency is likely produced when the freebase oil of meth is gassed into the hydrochloride salt of the compound. Methamphetamine that is produced by acid titration will yield a more solid crystal of the compound. If however, the methamphetamine that is gassed out of solution from the freebase oil is recrystallized using a solvent (generally methanol) the result is a dense crystal rock, similar to that of rock candy.
Methamphetamine that has a color to it, is not considered to be "pure" meth, as a impurity has resulted. A prime example is the blue meth depicted in AMC's hit T.V show Breaking Bad. In this example, a food coloring agent has been added during the final stage of crystallization. In this scenario, the purity is decreased so little, it could still be considered "pure" meth, as it's negligible due to the small amount used.
Other colors, such as pink or slight green could also be a coloring agent, but likely un-reacted precursor or intermediate used in the manufacturing process.
[top]Legal status of Methamphetamine
Methamphetamine is in schedule II of the United Nations Convention on Psychotropic
In the United States, methamphetamine is a schedule II stimulant. This means that, within the U.S., methamphetamine has recognized medical uses but it is illegal to sell without a DEA license and illegal to buy or possess without a license or prescription.
In the UK methamphetamine is a Class A drug under the The Misuse of Drugs Act 1971. The maximum penalty for unlawful possession of methamphetamine is 7 years in prison; for supplying or offering to supply methamphetamine or unlawful possession of methamphetamine with intent to supply the maximum penalty is life in prison; and for allowing premises you occupy or manage to be used unlawfully for the purpose of producing or supplying methamphetamine the maximum penalty is 14 years.
In Canada, methamphetamine has no recognized medical uses and is a Schedule I controlled substance, meaning that the maximum available sentences for distribution or production of methamphetamine is life in prison.
In Australia, methamphetamine is a schedule 8 controlled. This means that methamphetamine has recognized medical uses, however methamphetamine is never medically prescribed as there are no licensed manufacturers of methamphetamine in Australia.
[top]History of Methamphetamine
We begin with the discovery in China of a stimulant that was in a rare herb called Ma huang. This stimulant was used in Chinese medicine for over 5000 years. It’s not until the late 1800 that scientists are able to isolate the source of the stimulation. Nagayoshi Nagai was able to isolate ephedrine as the source of the stimulant properties of the Ma huang. 2 years later in 1887 Lazar Edelano is able to synthesis an ephedrine like amphetamine called phenyisopropylamine. This and other findings and experiments lead to the creation of methamphetamine in 1893 by none other than the one able to isolate the ephedrine to begin with, chemist Nagayoshi Nagai. It’s not until 26 years later that Akira Ogata was able to create crystallized methamphetamine.
American Gordon Alles of UCLA is able to reproduce Edelano’s results and synthesise phenyisopropylamine in America. This patent is then sold to Smith, Kline and French and marketed as Benzedrine. The public is able to freely abuse Benzedrine throughout the great depression and WWII. Benzedrine is reformulated into tablet form as a treatment for narcolepsy in 1937 and one year later methamphetamine is released to the German public as Pervitin. Most countries involved in WWII on both sides experimented and gave methamphetamine to soldiers to increase alertness for long missions and battles. This was taking place in the late 30’s and quietly at present day methamphetamine and amphetamines are used by most militaries throughout the world.
The first meth epidemic takes place in Japan between 1945-50 it spreads to Guam and the US Marshal islands. Later on in the 50’s and 60’s meth is marketed throughout the world as “pep pills” and sold for non-medical reasons. Also in the 50’s methamphetamine was used by Korean doctors to treat soldiers morphine
addiction not to mention during the 60’s that San Francisco drug clinics prescribed injections of methamphetamine to treat heroin
It wasn’t until 1970 that the US Congress decided to regulate methamphetamine and other drugs through passage of the Controlled Substances Act (basically the beginning of the drug war) this had an effect of forcing use and creation of the drug underground. It was during the 1980’s that new syntheses were discovered and smokeable forms of the drug were introduced to the world. This went on into the 1990’s when The US Congress again moved on methamphetamine when in 1996 the comprehensive methamphetamine control act was passed regulating mail orders and the precursors necessary to produce methamphetamine.
As of 2000 to present The US and the world have chosen methamphetamine as the hard drug of choice, surpassing Crack Cocaine
[top]More Methamphetamine Sections
[top]The Latest Methamphetamine Threads
, fifteenth edition (2013)
Created by Alfa
, 30-08-2009 at 16:15
Last edited by 5-HT2A
, 17-09-2014 at 06:40
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on 02-04-2014 at 21:13
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