is a euphoric stimulant research chemical
of the beta-ketone
family. It is a derivative of methcathinone
and the beta-keto analogue of MDMA. Methylone first appeared on the market in the form of a "legal high" product called Explosion. Its use has been documented since 2004. Effects and duration are similar to those of MDMA.
[top]Introduction to Methylone
Methylone, also known as "M1", 3,4-methylenedioxy-N-methylcathinone, and bk-MDMA is an entactogen (class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA
)) and stimulant of the amphetamine
, phenethylamine, and cathinone classes. Originally patented by Jacob Peyton and Alexander Shulgin
as an antidepressant in 1996, Methylone is a close structural analogue of MDMA, differing only by the addition of a β-ketone group.
Dosage of methylone
Oral Methylone Dosages
Threshold 60 - 120 mg
Light 100 - 150 mg
Common 100 - 250 mg
Strong 160 - 270 mg
very Strong 250 + mg
Onset : 15 - 60 minutes
Duration : 2 - 3.5 hours
Normal After Effects : 6 - 24 hours
dosage is the same as oral dosage but is not considered as rewarding,with a much shorter duration of action
[top]Ways of administration
Methylone can be administered through a variety of different routes, including oral, intranasal, intravenous, sublingual, and rectal administration. However oral consumption
appears to be the most popular route of administration, as the effects appear to be positive and consistent, most likely due to the copious amount of 5-HT serotonin
receptors which line the walls of the gastrointestinal tract.
[top]Effects of Methylone
- Mood lift
- Emotional bonding with others
- Increased musical appreciation
- Feelings of love and empathy
- Pupil dilation
- Increased perspiration
- Increased body temperature
- Increased heart rate
- Increased blood pressure
- Muscle tension
[top]Combinations with Methylone
Methylone should never be combined with any other drugs
that act on the serotonin system due to the risk for serotonin syndrome
to occur. Likewise combining methylone with any drug
that acts as an MAOI
inhibitor) is also dangerous and potentially fatal as serotonin syndrome may occur.
Methylone acts as a central nervous system stimulant, thus combining it with any other drug which also acts as a central nervous system stimulant may be dangerous or fatal due to overstimulation of the cardiovascular system.
[top]Different Uses for Methylone
Currently the only documented use for methylone is as a psychoactive drug sold in stores as a legal high and on the internet in its pure crystal or powder form.
[top]Pharmacology of Methylone
Methylone acts on the serotonin, norepinephrine, and dopamine
receptors as both a reuptake inhibitor and a releasing agent, though it has approximately 3x lower affinity for the serotonin transporter than that of MDMA. Likewise methylone's affinity for the vescular monoamine
transporter 2 (VMAT2) is 13x lower than that of MDMA, though its affinity towards the norepinephrine and dopamine receptors remains almost identical.
[top]Chemistry of Methylone
|Systematic (IUPAC) name:||1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one|
|Synonyms:||bk-MDMA, β-ketone-MDMA, bk-methylenedioxymethamphetamine, MDMC, 3,4-methylenedioxymethcathinone, N-methyl-MDC, 3,4-methylenedioxy-N-methylcathinone, N-methyl-3,4-methylenedioxycathinone, M1|
|Molecular Formula:||C11H13NO3 |
|Molar mass:||207.23 g/mol, 243.69 g/mol (hydrochloride) |
|CAS Registry Number:||186028-79-5, 186028-80-8 (hydrochloride)|
|Melting Point:||248.4 °C (hydrochloride) |
|Boiling Point:|| |
|Flash Point:||no data|
|Additionnal data:|| |
|Notes:||hydrochloride aspect : white powder |
[top]Reagent test results of Methylone
|Reagent || color produced || picture || video|
|Marquis || Yellow, strong yellow || - || -|
|Mandelin || Yellow, brown || - || - |
|Mecke || yellow to orange, brownish || - || -|
Originally Posted by NeuroChi
Reagent results for a sample of bk-MDMA which induced effects characteristic of the true compound:
Mecke: first yellow, then orange shortly after
Originally Posted by shadowchaser
[top]The dangers of Methylone
There are several dangers that are associated with methylone which should considered prior to its consumption. First and foremost methylone is considered to be a research chemical, thus its short and longer term side effects
have yet to be formally established through clinical trials. Methylone also acts as a powerful releasing agent on the serotonin system, thus certain combinations should be avoided so that serotonin syndrome does not occur.
Methylone acts as a central nervous system stimulant, meaning that users whom have a known cardiovascular disease or any other physical illnesses, should avoid its consumption so that a life threatening complication does not occur. Likewise as with any psychoactive drug, methylone should only be consumed by users whom are deemed mentally fit and stable to consume a psychoactive drug, as methylone may bring out a previously unnoticed underlying mental disorder.
Methylone is available in several forums such as in bath salts
or similar legal high packaging (often times cuts) or as a pure hydrochloride, hydrobromide, or fumaric salt.
A picture of the Explosion tubes, which were sold as "room-deodorizer" containing Methylone.
A picture of methylone in HCl form, ordered from a vendor online.
[top]Legal status of Methylone
Methylone was added to the Anlage II as of January 2012.
Methylone is a class B controlled substance in the UK as it is covered by a law controlling derivatives of cathinone outlined in the Misuse of Drugs Act 1971, Order 2010.
Methylone is covered under the medicine act, making it illegal to trade in due to its lack of offical registration.
Methylone is considered to be a Class C drug due to its structural similarity to methcathinone.
Methylone has been classified as a narcotic in Sweden since september 21st, 2010.
Methylone is considered to be an analog of amphetamine thus treated as a scheduled substance in Canada.
As of February 8th, 2008, methylone is considered to be illegal in the country of Denmark except for scientific and medicinal uses.
As of February 2011, methylone is considered to be a schedule I substance in Estonia.
Methylone is considered a hard drug in the country of Finland thus making it illegal to buy, sell, possess, or manufacture.
As of March 1st, 2011 methylone is considered to be a controlled substance in the Slovak Republic.
[top]History of Methylone
[top]Popularity of Methylone over time
[top]More Methylone Sections
[top]The latest Methylone threads
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