Home Wiki Studies Forum Groups Blog Video Images News Chat
Go Back   Drugs Forum > Wiki Articles > Drug Articles
Mark Forums Read
Register Tags


Drug Articles Articles about drugs

[top]Introduction to Mirtazapine

Mirtazapine is a tetracyclic antidepressant used primarily in the treatment of depression. Mirtazapine is one of the few noradrenergic and specific serotonergic antidepressants (NaSSAs). It has been demonstrated to have far fewer side effects than most other typical anti-depressants on the market.

Mirtazapine is unusual for an anti depressant as it has effects that are apparent instantly. The instant effects are sedating, which can help people with sleep, whereas the long term anti depressant/anxiety effects will not become apparent until amounts in the body have built up to a sufficient level over months of use. It takes 5 days for a given dosage to build in the bloodstream to stable levels.

[top]Using Mirtazapine

The usual starting dose of mirtazapine is 15 mg, given at bed-time. This can be increased to 45mg over time, but close doctor supervision is indicated for an increase above that amount.

[top]Ways of Administration

Mirtazapine is normally supplied in oral tablets.

[top]Effects of Mirtazapine

[top]Combinations with Mirtazapine

[top]Different Uses for Mirtazapine

Mirtazapine can also be prescribed for secondary symptoms of Autistic spectrum disorders, and for disorders such as anorexia when an anti-depressant is also appropriate.

[top]Pharmacology of Mirtazapine

Receptor Affinity pA2 or pKi
2-Adrenergic autoreceptor 7.7
2-Adrenergic heteroreceptor 8.0
Postsynaptic 2-adrenoceptor 7.3
Presynaptic 2-adrenoceptor 6.8
1-Adrenoceptor 6.5
Serotonin 5-HT1A 5.3
Serotonin 5-HT1B 4.9
Serotonin 5-HT1D 5.3
Serotonin 5-HT2A 8.2
Serotonin 5-HT2B 6.7
Serotonin 5-HT2C 7.9
Serotonin 5-HT3 8.1
Histamine H1 9.3
Muscarinic 6.2
Dopamine D1 5.8
Dopamine D2 5.6

[top]Chemistry of Mirtazapine

Systematic(IUPAC) name:1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Synonyms:1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]-azepine, 6-azamianserin, Org-3770, mepirzepine, Remeron, Zispin
Molecular Formula:C17H19N3
Molar mass:265.36 g/mol.
CAS Registry Number:61337-67-5
Melting Point:114-116C
Boiling Point:no data
Flash Point:no data
Solubility:Freely soluble in methanol, toluene; soluble in ethyl ether, chloroform; sparingly soluble in n-hexane; practically insoluble in water.
Additionnal data:none
Notes:Aspect : white crystals; crystallyzed from petroleum ether

[top]The Dangers of Mirtazapine

[top]Physical Health Risks

[top]Physical Problem 1

[top]Physical Problem 2


[top]Reported Deaths

When Robin Williams Committed suicide on August 11, 2014, the coronor's autopsy report found that he had taken Mirtazapine shortly before hanging himself. Mirtazapine was never found to be a causal factor in his death however.

[top]Mental Health Risks

[top]Mental Health Risk 1

[top]Mental Health Risk 2

[top]Side Effects

Some side effects of Mirtazapine include increased appetite, weight gain, and drowsiness. In extremely high doses it can cause hallucinations as a deliriant anti-histamine.


[top]Physical Addiction

[top]Mental Addiction

[top]Producing/Growing Mirtazapine

[top]Forms of Mirtazapine

[top]Legal Status of Mirtazapine

[top]United Nations


Mirtazapine is a schedule IV (4) drug in the U.S. as of March 2015.



Mirtazapine is a prescription only drug in the United Kingdom

[top]Other Countries

[top]History of Mirtazapine

[top]More Mirtazapine Sections

[top]The Latest Mirtazapine Threads

  Article / Page Starter Last Post Comments Views
06-10-2015 18:25
by Ghetto_Chem Go to last post
4 388
05-10-2015 17:30
by gonzochef Go to last post
1 130
03-10-2015 21:39
by Potter Go to last post
1 160
02-10-2015 07:25
by Dancingonmyhands Go to last post
4 2,341
01-10-2015 04:37
by lkt004 Go to last post
7 650
30-09-2015 03:33
by Sable Go to last post
14 1,891
24-09-2015 05:55
by Lady Iris Go to last post
9 776
21-09-2015 00:27
by VikingGunner Go to last post
7 787
Alien Sex Fiend
20-09-2015 21:27
by prescriptionperil Go to last post
9 789
killa dork
17-09-2015 18:37
by bluntwraps Go to last post
56 9,629


[1]Merck Index, fifteenth edition (2013)

Created by Synesthesiac, 07-04-2012 at 21:53
Last edited by TheHippyWanderer, 18-07-2015 at 03:30
Last comment by NeuroChi on 09-09-2015 at 04:43
7 Comments, 24,172 Views

Share this on:
Page Tools

Posting Rules
You may not create new articles
You may not edit articles
You may not protect articles

You may not post comments
You may not post attachments
You may not edit your comments

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Sitelinks: Information:

All times are GMT +1. The time now is 04:39.

Copyright: SIN Foundation 2003 - 2014, All rights reserved