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Oxymorphone or 14-Hydroxydihydromorphinone is a semi-synthetic opioid narcotic analgesic. It's analgesic potency is higher than morphine per given mg. Although it has euphoric and histamine properties, they're not proportional to that of analgesic equivalence. Overdose can cause respiratory depression as the case for many opioid.


[top]Introduction to Oxymorphone

[top]Using Oxymorphone

Take this medicine as indicated by your physician.

[top]Ways of administration


[top]Effects of Oxymorphone

[top]Combinations with Oxymorphone

Below are noted drug interactions with Opana as specified by manufacturer Endo Pharmaceuticals
• CNS depressants: Increased risk of respiratory depression, hypotension, profound sedation, coma or death when combined with OPANA ER. When combined therapy with CNS depressant is contemplated, the dose of one or both agents should be reduced.
• Mixed agonist/antagonist opioids (i.e., pentazocine, nalbuphine, and butorphanol): May reduce analgesic effect and/or precipitate withdrawal symptoms.
• Cimetidine: Combination use with OPANA ER may precipitate confusion, disorientation, respiratory depression, apnea, seizures.
• Anticholinergics: Concurrent use with OPANA ER may result in urinary retention and/or severe constipation, which may lead to paralytic ileus.
Monoamine oxidase inhibitors (MAOIs): Potentiate the action of opioids. OPANA ER should not be used in patients taking MAOIs or within 14 days of stopping such treatment.

Extreme caution should be used when Opana is taken in combination with the following drugs;
- Alcohol - when combined with Opana will cause further depression of the respiratory system and CNS which can increase the chance of loss of consciousness, seizure, death etc.
- Benzos (xanax, klonopin, valium) - when combined with Opana will cause further depression of the respiratory system and CNS which increases the chance of injuries, seizure, death, blackouts etc.
- Barbituates - when combined with Opana will cause further depression of the CNS. Increasing the chances of injuries and fatalities.
**If possible the use of the above drugs should be avoided while on Opana to ensure the most harm prevention.

[top]Different Uses for Oxymorphone

[top]Pharmacology of Oxymorphone

LD50 (mg/kg) (as the freebase) [2] :
Mice : 200 subcutaneously

[top]Chemistry of Oxymorphone

Systematic(IUPAC) name:4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one
Synonyms:(14S)-14-hydroxydihydromorphinone, dihydrohydroxymorphinone, di-hydro-14-hydroxymorphinone, 14-hydroxydihydromorphinone; Numorphan, Opana (hydrochloride)
Molecular Formula:C17H19NO4, C17H19NO4.HCl (hydrochloride)
Molar mass: 301.34 g/mol, 337.80 g/mol (hydrochloride)
CAS Registry Number:76-41-5, 357-07-3 (hydrochloride)
Melting Point:248-249°C
Boiling Point:no data
Flash Point:no data
Solubility:Freebase soluble in boiling acetone and chloroform; readily soluble in aqueous alkalies; moderately soluble in boiling ethanol; sparingly soluble in benzene. Hydrochloride freely soluble in water; sparingly soluble in ethanol, ether
Additionnal data:Hydrochloride pKa1 8.17; pKa1 9.54; partition coefficient (octanol/water, 37°C, pH 7.4) 0.98
Notes:Freebase crystallized from ethanol, ethyl acetate or benzene. Hydrochloride aspect : white or slightly off white odorless powder; darkens on exposure to light

[top]The dangers of Oxymorphone

Respiratory depression in the event of overdose can lead to respiratory failure and death.

[top]Producing Oxymorphone

Oxymorphone is produced from thebaïne by the same way as oxycodone. The final step consists in the demethylation of oxycodone by hydrogen bromide [1].

[top]Forms of Oxymorphone

The brand name of Oxymorphone is Opana, which is manufactured by Endo Pharmaceuticals. Endo Pharmaceuticals offers Opana in 3 forms; an extended release (ER) pill, an instant release (IR) pill and an injectable form.

Opana ER is manufactured in the following doses;
  • 5mg tablet
  • 7.5mg tablet
  • 10mg tablet
  • 15mg tablet
  • 20mg tablet
  • 30mg tablet
  • 40mg tablet

Opana IR is manufactured in the following doses;
  • 5mg tablets
  • 10mg tablets

Injectable Opana comes in 1mg/mL, 1mL ampules.

Generic manufactures of Oxymorphone HCL include Qaulitest, Roxane Labs and, Actavis Elizabe. Doses are manufactured as the following;
  • IR 5mg tablet - by Roxane & Qaulitest
  • ER 7.5mg tablet - by Actavis Elizabe
  • IR 10mg tablet - by Roxan & Qualitest
  • ER 15mg tablet - by Activas Elizabe

[top]Legal status of Oxymorphone

Oxymorphone is a controlled substance 21 CFR 1308.12

[top]United Nations


CII [1]


[top]Other Countries

[top]History of Oxymorphone

[top]More Oxymorphone Sections

[top]The latest Oxymorphone threads

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  1. ^ https://drugs-forum.com/forum/local_links.php?action=jump&catid=15&id=10890

[1] Synthesis of Essential Drugs, 1st edition, Ruben Vardanyan & Victor Hruby, Elsevier
[2]Merck Index, fifteenth edition (2013)
Read more: https://drugs-forum.com/forum/sho...#ixzz1UJa31Z1F

Created by Nanashi, 07-08-2011 at 05:52
Last edited by John_bob, 01-05-2014 at 20:21
Last comment by John_bob on 16-03-2014 at 19:53
5 Comments, 34,658 Views

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