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[top]Introduction to Psilocybin

Psilocybin is the phosphate ester of psilocin. It is one of the psychoactive chemicals present in mushrooms from a multitude of genera, most notably Psilocybe (along with psilocin, baeocystin and norbaeocystin), collectively referred to as Magic Mushrooms. Psilocybin is metabolized in the body to psilocin.

[top]Using Psilocybin

[top]Ways of administration

[top]Effects of Psilocybin

[top]Combinations with Psilocybin

[top]Different Uses for Psilocybin

[top]Pharmacology of Psilocybin

LD50 (mg/kg) [2] :
Mice : 285 intravenously
Rat : 280 intravenously
Rabbit : 12.5 intravenously

[top]Chemistry of Psilocybin

Systematic (IUPAC) name:[3-(2-Dimethylaminoethyl)-1H-indol-4-yl] dihydrogen phosphate
Synonyms:3-[2-(Dimethylamino)ethyl]-1H-indol-4-ol 4-(dihydrogen phosphate), O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine, Indocybin
Molecular Formula:C12H17N2O4P
Molar mass:284.25 g/mol [1]
CAS Registry Number:520-52-5
Melting Point:220-228C (crystals from boiling water)[2], 185-195C (crystals from boiling methanol)[2]
Boiling Point:no data
Flash Point:no data
Solubility:soluble in 20 parts boiling water, 120 parts boiling methanol; slightly soluble in ethanol; practically insoluble in chloroform, benzene[2]; slightly soluble in ether, acetone; insoluble in hexane[3]
Additionnal data:pH 5.2 in 50 % aqueous ethanol[2]
Notes:crystallized from water or methanol[2]

The LD50 of psilocybin is 280 milligrams per kilogram (mg/kg), and approximately 12.5 mg/kg when administered intravenously in rabbits.

Considering the average Psilocybe cubensis is 1% psilocybin by weight it would take 37lbs (17kg) of fresh mushrooms, or 1.3lbs (1.7kg) of dry mushrooms for a 130 lb (60kg) adult to reach the LD50.

*Stamets, Paul. Psilocybin Mushrooms of the World. 1996

[top]Reagent test results of Psilocybin

Reagent color produced
Marquis Dull Orange
Frohede's Grey blue -> green -> yellow

[top]The dangers of Psilocybin

[top]Producing/Growing Psilocybin

[top]Forms of Psilocybin

[top]Legal status of Psilocybin

Psilocybin is a controlled substance 21 CFR 1308.11

[top]United Nations



[top]United Kingdom

[top]Other Countries

[top]History of Psilocybin

[top]More Psilocybin Sections

[top]The latest Psilocybin threads

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[1]Calculated from Atomic Weights of the Elements, 2007
[2]Merck Index, fifteenth edition (2013)
[3] psilocybin monograph

Contributors: John_bob, Docta, Nnizzle , NeuroChi, Alfa
Created by Alfa, 18-12-2010 at 15:12
Last edited by John_bob, 13-12-2014 at 12:53
Last comment by Basoodler on 19-09-2012 at 18:30
3 Comments, 19,791 Views

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