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[top]Introduction to Tetrahydrocannabinol




[top]Using Tetrahydrocannabinol


THC is generally used as cannabis or some cannabis-derived preparation (hashish, space cakes, etc). THC, in its synthetic form (Dronabinol) to be used orally, is also available in some countries.

[top]Ways of Administration


THC, when derived from a natural source can be smoked, vaporized or ingested as cannabis and related preparations.

Synthetic THC is available for oral administration. In some studies, THC is administered intravenously.

[top]Effects of Tetrahydrocannabinol


The effects of THC are similar to those of cannabis, although some differences exist.

[top]Objective effects


- Reduced intraocular pressure

[top]Subjective effects


- Increased appetite

[top]Combinations with Tetrahydrocannabinol


THC is usually combined to the other cannabinoids found in cannabis. The combinations are the same as those of cannabis.

[top]Different Uses for Tetrahydrocannabinol

[top]Therapeutic


THC, as Dronabinol, is used to increase appetite of aids patients.


[top]Pharmacology of Tetrahydrocannabinol


LD50 (mg/kg) (sesame oil emulsion of ∆9-THC)[1] :
Male rat : 800 orally, 672 intraperitoneally, 35.5 intravenously

LD50 (mg/kg) (∆8-THC)[1]:
Mice : 27.5 intravenously


[top]Chemistry of Tetrahydrocannabinol

From a chemical point of view, THC consist of seven isomers, depending on the position of the insaturation on the "upper" ring consisting of the carbons 6a-7-8-9-10-10a.

Title compound9-THC
Systematic (IUPAC) name:(−)-(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
Synonyms:(6aR,10aR)-6a,7,8,10a-tetrahydro-3-pentyl-6H-dibenzo[b,d]pyran-1-ol, ()-∆1-3,4-trans-tetrahydrocannabinol, ∆9-THC, ∆1-THC, dronabinol, QCD-84924, Marinol
Molecular Formula:C21H30O2
Molar mass:314.46 g/mol[2]
CAS Registry Number:1972-08-3
Melting Point:no data
Boiling Point:200C @ 0.02 mmHg[1], also reported 157C[3]
Flash Point:no data
Solubility:Insoluble in water (0.0028 mg/mL[4]); Freely soluble in benzene and aromatic solvents, butane and other alkanes; Soluble in acetone, isopropanol, ethanol[1].
Additionnal data:pKa 10.6[1]
Notes:Aspect : light yellow resinous oil; hardens upon refrigeration[1]
 
Title compound8-THC
Systematic (IUPAC) name:(−)-(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
Synonyms:()-∆6-3,4-trans-tetrahydrocannabinol, ∆8-THC, ∆6-THC
Molecular Formula:C21H30O2
Molar mass:314.46 g/mol[2]
CAS Registry Number:5957-75-5
Melting Point:no data
Boiling Point:200C @ 0.001 mmHg[1]
Flash Point:no data
Solubility:no data
Additionnal data:none
Notes:none
Apart from the aforementionned positionnal isomers, 4 stereoisomers exists depending on the absolute configuration of the 6a and 10a carbons.






[top]The Dangers of Tetrahydrocannabinol

[top]Physical Health Risks

[top]<Physical Problem 1 - Please Identify and Add Others As Necessary>

[top]<Physical Problem 2 - Please Identify and Add Others As Necessary>

[top]Overdose

[top]Reported Deaths

[top]Mental Health Risks

[top]<Mental Health Risk 1 - Please Identify and Add Others As Necessary>

[top]<Mental Health Risk 2 - Please Identify and Add Others As Necessary>

[top]Side Effects

[top]Addiction

[top]Physical Addiction

[top]Mental Addiction



[top]Producing Tetrahydrocannabinol


Tetrahydrocannabinol is produced via cannabis cultivation followed by extraction.

[top]Biosynthesis of Tetrahydrocannabinol



[top]Forms of Tetrahydrocannabinol



[top]Legal Status of Tetrahydrocannabinol


Tetrahydrocannabinol is a controlled substance 21 CFR 1308.11

[top]United Nations

[top]USA

[top]EU

[top]Other Countries



[top]History of Tetrahydrocannabinol



[top]More Tetrahydrocannabinol Sections




[top]The Latest Tetrahydrocannabinol Threads


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[top]References

  1. ^ a b c d e f g Merck Index, fifteenth edition (2013)
  2. ^ a b Calculated from Atomic Weights of the Elements, 2007
  3. ^ John M. McPartland, Ethan B. Russo; Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts? (2001)
  4. ^ Garrett, Edward R.; Hunt, C. Anthony (July 1974). "Physicochemical properties, solubility, and protein binding of Δ9-tetrahydrocannabinol". J. Pharm. Sci. 63 (7): 105664.


Contributors: Docta, John_bob
Created by John_bob, 10-05-2014 at 21:31
Last edited by Docta, 02-08-2015 at 06:04
Last comment by NeuroChi on 02-11-2015 at 14:06
2 Comments, 17,195 Views

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