I do not use Clonidine for pain. I actually added it originally as a sleep aide but then my BP numbers were climbing and not controlled on my usual medication so I added Clonidine at bedtime regularly. It fixed my morning numbers. Sometimes it is bad that I can write my own scripts. I do hearts. Not much point having someone with less training managing my high blood pressure! Lol. Anyhow, it helps sleep, anxiety, and does help with muscle issues...so in theory it might help reduce pain sensations. I see my pain guy in 2 weeks. I will ask him about this.