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4-Dimethylaminopyridine as a catalyst in heroin synthesis

4-Dimethylaminopyridine as a catalyst in heroin synthesis

  1. Guigz
    Document by Forensic Science International, for the Slovenian ministry of interior which show the role playing by 4-Dimethylaminopyridine in heroin synthesis.

    Abstract:
    In this paper, we describe an acetylating method for fast synthesis of heroin from morphine in the presence of 4-
    dimethylaminopyridine (4-DMAP) as a catalyst. In the reaction which led to heroin formation, the morphine base was
    subjected to a solution made up of 4-DMAP (catalyst), methylene chloride (solvent) and acetic anhydride (acetylating agent).
    We showed that in comparison with classic acetylating procedures, reaction time can be reduced from at least several hours at
    elevated temperatures to