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A SYNERGISTIC COMBINATION: GABAPENTIN AND PREGABALIN - European Patent EP1196160

A SYNERGISTIC COMBINATION: GABAPENTIN AND PREGABALIN - European Patent EP1196160

  1. honourableone
    An approved patent application for combining pregabalin and gabapentin. Contains useful information on the relationship between pregabalin and gabapentin, as well as other information such as viable methods of administration for both drugs.

Recent Reviews

  1. bobes
    bobes
    5/5,
    Version: 2009-09-06
    this blew me away as well, destroying my belief that pregabalin was simply (approx) twice the strength of gabapentin and that they shared almost identical profiles. Good find. The statement suggesting that no cross tolerance exists was really striking.
  2. GeographyGeography
    GeographyGeography
    4/5,
    Version: 2009-09-06
    Fascinating. I have often wondered about the tendency for these two drugs to create cross tolerance, and at one time I believed it did, but now see that it has been established they do not. I am curious as to why the drugs need to be mixed together to achieve the synergistic effect...couldn't one just take a 300mg gabapentin (Neurontin[US]) and a 300mg pregabalin(lyrica[US]) at the same time?
    I am interested in the synergy these drugs individually have with benzodiazepines, gabaergic drugs generally, and narcotic/opioid analgesics. Each, when taken with a drug from any of these groups seems to amplify the effects of the second quite profoundly. If this is so, what kind of synergy would a mixture of gabapentin and pregabalin plus, for instance, 10mg oxycodone do?