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A Two-step Method for the Preparation of Chiral Cathinones

A Two-step Method for the Preparation of Chiral Cathinones

  1. ThirdEyeFloond
    Tetrahedron Asymmetry 14 (2003) 1473-1477

    M. Osorio-Olivares, M. Caroli Rezende, S. SepĂșlveda-Boza, B.K. Cassels, R.F. Baggio y J.C. Muñoz Acevedo


    Abstract
    A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2 ('cathinones') is described, involving initial Friedel-Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by acid hydrolysis of the intermediate trifluoroacetamido intermediates 1, for which X-ray diffraction analysis confirmed the structures.