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Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review

Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review

  1. Bajeda
    Addiction. 2003 Oct;98(10):1371-8

    Hajak G (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Müller WE (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Wittchen HU (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Pittrow D (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1), Kirch W (http://www.ncbi.nlm.nih.gov/sites/e...bmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1).

    The relative incidence of reported dependence is similar for both drugs and remarkably lower than that of benzodiazepines used for the treatment of disturbed sleep. The findings offer the conclusion that zolpidem and zopiclone are relatively safe drugs. ْPatients with a history of abuse or dependence and those with psychiatric diseases seem to be at increased risk of abuse of these agents.