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Activation of the GABAA Receptor Ameliorates the Cochlear Excitotoxicity Caused by Kainic Acid in th

Activation of the GABAA Receptor Ameliorates the Cochlear Excitotoxicity Caused by Kainic Acid in th

  1. mersann
    Activation of the GABAA Receptor Ameliorates the
    Cochlear Excitotoxicity Caused by Kainic Acid in the
    Guinea Pig

    Authors: Shuhei Sakai, Keiji Tabuchi, Hidekazu Murashita and Akira Hara

    First Abstract Sentences:

    Excitotoxicity is a major neurotoxic mechanism in cochlear disorders, including cochlear
    ischemic injury and acoustic injury. Kainic acid (KA), an excitatory amino acid, can dam-
    age glutamatergic neurons. The application of KA to the round window membrane, an
    opening of the cochlear bony labyrinth to the middle ear, induces excitotoxicity of cochlear
    afferent dendrites and significantly decreases the amplitude of compound action potential
    of the cochlea (CAP), a cochlear potential generated by activation of the auditory nerve
    fibers. On the other hand, muscimol, a gamma-aminobutyric acid (GABA)A receptor ago-
    nist, is neuroprotective in excitotoxicity in the central nervous system. Here we studied
    whether activation of GABA receptor decreased the excitotoxicity of the cochlea caused
    by KA. KA (10 mM) was applied to the round window membrane of guinea pigs for 30
    minutes.