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Acute delirium in patients with multiple sclerosis treated with pregabalin

Acute delirium in patients with multiple sclerosis treated with pregabalin

  1. staples
    Pregabalin (PGB, Lyrica) is an isomer of gama-aminobutyric acid that is approved as an adjunctive therapy for adult patients with partial seizure. Animal model showed that PGB selectively binds to the alpha2-beta protein of the voltage-gated calcium channels in various central nervous system (CNS) regions. Several studies have demonstrated its efficacy in the treatment of several neuropathic pain such as trigeminal neuralgia, painful diabetic neuropathy, and postherpetic neuralgia. Pain occurs in approximately 40% of patients with multiple sclerosis (MS). They are usually treated with antiepileptic medications such as carbamazepine or gabapentin. Patients with MS treated with antiepileptic medication more frequently report adverse effects on the CNS compared with other disease. We describe 2 patients with MS undergoing PGB therapy for pain who developed acute delirium and delusion that ceased with treatment discontinuation.