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Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Healt

Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Healt

  1. Johan73
    Aldehydes are organic compounds that are widespread in nature. They can be formed endogenously by lipid peroxidation (LPO), carbohydrate or metabolism ascorbate autoxidation, amine oxidases, cytochrome P-450s, or myeloperoxidase-catalyzed metabolic activation. This review compares the reactivity of many aldehydes towards biomolecules particularly macromolecules. Furthermore, it includes not only aldehydes of environmental or occupational concerns but also dietary aldehydes and aldehydes formed endogenously by intermediary metabolism. Drugs that are aldehydes or form reactive aldehyde metabolites that cause side-effect toxicity are also included.

    Retrieved 7/13/09 from http://www.redorbit.com/modules/news/tools.php?tool=print&id=351996