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Amphetamine effects in man: Paradoxical drowsiness and lowered electrical brain activity (CNV) (1974

Amphetamine effects in man: Paradoxical drowsiness and lowered electrical brain activity (CNV) (1974

  1. Gradient
    Joseph J. Tecce and Jonathan O. Cole

    Science 1974 Aug 2;185(149):451-3.

    Thirteen of 20 normal adults given 10 milligrams of dextroamphetamine exhibited paradoxical drowsiness accompanied by lowered electrical brain activity (contingent negative variation, or CNV) in the first hour post-drug. During this period, seven subjects showed behavioral alertness and increased CNV amplitude. Both groups of subjects showed heightened alertness 2 and 3 hours post-drug. Amphetamine is not a simple stimulant of the central nervous system but can also act as a depressant.