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Antiinflammatory effect of salvinorin A in vivo

Antiinflammatory effect of salvinorin A in vivo

  1. venkecske
    Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo
    Aviello G, Borrelli F, Guida F, Romano B et al.
    Journal of Molecular Medicine 2011 [Epub]

    The hallucinogenic compound, salvinorin A, is a potent κ-opioid receptor agonist. Other target(s), such as the cannabinoid CB1 receptor, have also been proposed to explain its multiple pharmacological actions. In vivo, salvinorin A reduced the lipopolysaccharide- and the carrageenan-induced paw oedema and formalin-induced inflammatory pain, in a nor-binaltorphimine and rimonabant-sensitive manner. It is concluded that salvinorin A-via KORs and CB1 receptors-exerts ultrapotent actions on macrophages and also shows moderate antinflammatory effects in vivo.