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Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycete

Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycete

  1. Calliope
    Cancer Epidemiol. Biomarkers Prev. 4 (3): 275–81. 1995. PMID 7606203.

    Kobayashi, H ; Matsunaga, K ; Oguchi, Y

    Abstract
    PSK, a protein-bound polysaccharide obtained from cultured mycelia of Coriolus versicolor in basidiomycetes, is a biological response modifier, diverse operations of which include an antitumor action. We have previously reviewed recent research which had demonstrated that in animals, PSK has a preventive effect on chemical carcinogen-induced, radiation-induced, and spontaneously developed carcinogenesis (Kobayashi et al., Cancer Epidemiol., Biomarkers & Prev., 2: 271-276, 1993). We now focus on the effects of PSK once the progression of carcinogenesis has begun, and review what is now known of the preventive action of PSK on cancer metastasis. Recent research reports that PSK suppresses pulmonary metastasis of methylcholanthrene-induced sarcomas, human prostate cancer DU145M, and lymphatic metastasis of mouse leukemia P388, and that it has prolonged the survival period in spontaneous metastasis models. PSK also suppresses the metastasis of rat hepatoma AH60C, mouse colon cancer colon 26, and mouse leukemia RL male 1 in artificial metastasis models. PSK influences the steps of cancer metastasis in a number of ways: (a) by suppression of intravasation through the inhibition of tumor invasion, adhesion and production of cell matrix-degrading enzymes; (b) by suppression of tumor cell attachment to endothelial cells through the inhibition of tumor cell-induced platelet aggregation; (c) by suppression of tumor cell migration after extravasation through the inhibition of tumor cell motility; and (d) by suppression of tumor growth after extravasation through the inhibition of angiogenesis, the modulation of cytokine production, and the augmentation of effector cell functions. In addition, PSK has suppressed the malignant progression of mouse tumor cells through superoxide trapping. It therefore seems that P5K suppresses cancer metastasis at any number of different steps rather than at one particular step, and that its primary action mechanism can be ascribed to direct action on the tumor cell as well as to immunomodulation. Since P5K has few side effects and can be administered p.o. over long periods of time, it appears to be a useful agent for controlling or preventing cancer metastasis.
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