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Antipsychotic drug-induced dysphoria

Antipsychotic drug-induced dysphoria

  1. catseye
    DJ King, M Burke and RA Lucas

    The British Journal of Psychiatry, 1995 167: 480-482

    Background. Dysphoric reactions to antipsychotic medication are well recognised in
    association with akathisia, but can also occur independently.
    Method. Fifty-one healthy volunteers were given haloperidol 5 mg in two consecutive
    pharmacokinetic studies.
    Results. Dysphoria occurred in about 40% of the subjects on both occasions, but akathisia
    was only detected in 8% (first study) and 16% (second study). All adverse effects were
    transient and were abolished in nine of the ten subjects given procyclidine.
    Conclusions. While dysphoria is a well-recognised reaction in healthy volunteers, it is probably
    insufficiently recognised in patients, particularly if it occurs in the absence of akathisia. Better
    detection could improve compliance in patients.

Recent Reviews

  1. Mindless
    Version: 2011-01-18
    A most useful and intersting study, especially the potential for dysphoria in the absence of extrapyramidal effects and the therapeutic potential of procyclidine.