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Anxiogenic Action of Ibogaine (2001)

Anxiogenic Action of Ibogaine (2001)

  1. Jatelka
    Alkaloids Chem Biol. 2001;56:227-33.

    Popik P Wróbel M.

    In the current paradigm of drug development, findings gained in behavioral research ultimately direct our understanding of the drug’s mechanism of action, provide evidence of its effectiveness in an animal model, and ultimately decide whether a substance becomes a therapeutic agent (15). Findings gathered in behavioral studies often raise questions concerning whether the given substance may or may not be effectively used in a given clinical application, and also about its “side effects.” In addition, the effects found in behavioral studies that are not directly related to the purported mechanism of action often raise new questions such as the relevance of a “side effect” to a therapeutic action. This appears to be the case for ibogaine that, besides diminishing self-administration of drugs of abuse and alleviating the severity of opioid withdrawal, produces psychotomimetic effects, affects learning and memory processes (16-18), and has anxiogenic actions (14).
    It is beyond the scope of this overview to provide direct evidence linking these “miscellaneous” or “side-effect”-like actions of ibogaine to its purported “antiaddictive” effects. Nonetheless, these “miscellaneous” or “side-effect”-like actions of ibogaine cannot be neglected, since they may indeed have some therapeutic implications, and their understanding may facilitate the discovery of its molecular mechanism(s) of action.
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