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Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzi

Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzi

  1. Phenoxide
    Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen

    A. von Hunger, J. Kebrle, A. Rossi, K. Hoffmann

    Helvetica Chimica Acta (1960), Volume XLIII, No. 132

    Abstract: The synthesis of a series of 1-aminoalkyl-2-benzyl-nitro-benzimidazoles is described. Many of the 5-nitro-benzimidazoles prepared show strong analgesic activity. 1-(β-Diethylamino-ethyl)-2-(p-ethoxy-benzyl)-5-nitro-benzimidazole (XXXVIII) is 1000 times as potent as morphine and therefore the most active analgesic known until now.

    [article in german]