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Beta-Carboline alkaloids: biochemical and pharmacological functions.

Beta-Carboline alkaloids: biochemical and pharmacological functions.

  1. Quantum Dude
    Curr Med Chem 2007;14(4):479-500


    Abstract: -Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity,
    some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects,
    mammalians as well as human tissues and body fluids. These compounds are of great interest due to their diverse biological
    activities. Particularly, these compounds have been shown to intercalate into DNA, to inhibit CDK, Topisomerase, and
    monoamine oxidase, and to interact with benzodiazepine receptors and 5-hydroxy serotonin receptors. Furthermore, these
    chemicals also demonstrated a broad spectrum of pharmacological properties including sedative, anxiolytic, hypnotic,
    anticonvulsant, antitumor, antiviral, antiparasitic as well as antimicrobial activities. In this review, we summerized the
    biochemical and pharmacological functions of -carboline alkaloids.