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Buprenorphine and methadone maintenance treatment of heroin addicts preserves immune function (2008)

Buprenorphine and methadone maintenance treatment of heroin addicts preserves immune function (2008)

  1. mersann
    Authors: Paola Sacerdote, Silvia Franchi, Gilberto Gerra, Vincenzo Leccese, Alberto E. Panerai, Lorenzo Somaini
    Abstract beginning: Opiate addiction influences many physiological functions including immune responses. The objective of this study was to investigate the immune system function in heroin addicted patients submitted to methadone or buprenorphine maintenance treatment compared to untreated heroin addicts and healthy controls. Four groups were studied: group A included nine heroin addicted subjects, who were still injecting heroin; groups B and C were composed of 12 patients previously addicted to heroin, being treated with methadone (mean dosage 58 ± 12.7 mg/day) or buprenorphine (mean dose 9.3 ± 2.3 mg/day) since at least 6 months; group D was composed of 15 sex and age matched healthy controls. Lymphoproliferation and peripheral mononuclear cell cultures production of the Th1 cytokines IL-2 and IFN-c, the Th2 cytokine IL-4, and of the pro-inflammatory cytokine TNF-a were evaluated in all the patients and controls.