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Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor

Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor

  1. BitterSweet
    Roberto Ciccocioppo, Daina Economidou, Roberto Rimondini, Wolfgang Sommer, Maurizio Massi, Markus Heilig
    Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System
    Biological Psychiatry, Volume 61, Issue 1, 1 January 2007, Pages 4–12
    http://www.sciencedirect.com/science/article/pii/S0006322306001028

    Activation of the NOP receptor by its endogenous ligand nociceptin/orphanin FQ reduces ethanol intake in genetically selected alcohol preferring Marchigian Sardinian alcohol preferring (msP) rats. Here we evaluated whether buprenorphine, a partial agonist at μ-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors.