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Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression

Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression

  1. Mindless
    Examination of value of each of these drugs in treatment resistant depression and in cases of poor tolerance re SSRIs.

    Among patients who cannot tolerate or who do not have a remission in response to an initial SSRI, approximately one in four patients had a remission on switching to sustained-release bupropion, sertraline, or extended-release venlafaxine; these three drugs had similar efficacy and tolerability. These findings highlight the need for more broadly effective antidepressant treatments.