1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP

C-(4,5,6-Trimethoxyindan-1-yl)methanamine: A Mescaline Analogue Designed Using a Homology Model of t

C-(4,5,6-Trimethoxyindan-1-yl)methanamine: A Mescaline Analogue Designed Using a Homology Model of t

  1. Desertfox
    Jimscaline was created by Dr. Nichols first published about in 2006. !!!!!!!:crazy

    Thomas H. McLean, James J. Chambers, Jason C. Parrish, Michael R. Braden, Danuta Marona-Lewicka,
    Deborah Kurrasch-Orbaugh, and David E. Nichols
    J. Med. Chem. 2006, 49, 4269-4274

    A conformationally restricted analogue of mescaline, C-(4,5,6-trimethoxyindan-1-yl)-methanamine, was
    designed using a 5-HT2A receptor homology model. The compound possessed 3-fold higher affinity and
    potency than and efficacy equal to that of mescaline at the 5-HT2A receptor. The new analogue substituted
    fully for LSD in drug discrimination studies and was 5-fold more potent than mescaline. Resolution of this
    analogue into its enantiomers corroborated the docking experiments, showing the R-(+) isomer to have
    higher affinity and potency and to have efficacy similar to that of mescaline at the 5-HT2A receptor